Oral Magnesium Oxide Prophylaxis of Frequent Migrainous Headache in Children: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Wang, Fong; Eeden, Stephen K. Van Den; Ackerson, Lynn; Salk, Susan E.; Reince, Robyn H.; Elin, Ronald J.

doi:10.1046/j.1526-4610.2003.03102.x

Cited by 205 publications

(88 citation statements)

References 43 publications

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“…When compared with healthy control, pediatric migraine patients (with and without aura) showed a significant reduction in serum, red blood cells, and mononuclear blood cell magnesium concentration (Mazzotta et al 1999, Soriani et al 1995. In a randomized, double-blind, placebo-controlled trial (Wang et al 2003), children and adolescents ages 3-17 who were given magnesium oxide showed a statistically significant trend toward headache frequency reduction, although the primary outcome measure was not significantly different.…”

Section: Therapeutic Trialsmentioning

confidence: 97%

Why all migraine patients should be treated with magnesium

Mauskop¹,

Varughese

2012

J Neural Transm

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Section: Therapeutic Trialsmentioning

confidence: 97%

Why all migraine patients should be treated with magnesium

Mauskop¹,

Varughese

2012

J Neural Transm

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“…Reduction in migraine headache frequency and severity was demonstrated in pediatric patients by Wang and colleagues [6]. In this placebo-controlled trial, 58 patients supplemented with oral magnesium oxide 9 mg/kg/day in three divided doses (elemental magnesium 5.4 mg/kg/day) for 16 weeks exhibited a significant downward trend in the frequency and severity of migraine headaches.…”

Section: Discussionmentioning

confidence: 87%

“…However, there is a small body of evidence demonstrating the efficacy of magnesium in the prophylaxis of migraine [5,6] and tension-type headaches [7], and in reducing pain scores in patients with complex regional pain syndrome (CRPS) type 1 [8].…”

Section: Discussionmentioning

confidence: 99%

Rapid Resolution of Chronic Back Pain with Magnesium Glycinate in a Pediatric Patient

Sewell¹

2012

J Pain Relief

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A 10-year-old male presented to a pediatric complex chronic pain clinic with debilitating back pain associated with vertebral compression fractures secondary to corticosteroid-induced osteoporosis. The pain failed to respond to routine analgesics and zoledronic acid. Oral magnesium glycinate and topical magnesium/guaifenesin cream were initiated upon presentation to the clinic, and resulted in a rapid and sustained reduction in pain, increased flexibility and improved quality of life. Magnesium is a known N-methyl-D-aspartate receptor antagonist, and should be considered in the management of chronic pain. The roles of glycine and guaifenesin in the management of chronic pain are not well-understood, but may warrant further examination in the context of chronic pain.

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“…treatment (9 mg/kg b.w. daily) (Wang et al 2003). Another survey did not find any difference between subjects treated with 400 mg riboflavine, 300 mg Mg 2?…”

Section: Magnesium Therapy In the Prophylaxis Of Migrainementioning

confidence: 93%

Should magnesium be given to every migraineur? No

Párdutz

Vécsei

2012

J Neural Transm

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Migraine is one of the most common neurological disorders that affects young people, causing a considerable degree of disability in the active population, with an enormous consequent socio-economic impact. Despite intensive research, the pathomechanism of migraine is not completely understood and its fully effective therapy remains to be achieved. A number of experimental studies have implicated the importance of magnesium ion in the pathophysiology of this condition. Magnesium has been also administered for both prophylactic and acute therapy in migraine, but the question of its efficacy has not been studied adequately. The data available suggest that magnesium has a potential role in the prophylaxis, but the results in acute therapy are far less convincing. With a good side effect profile, magnesium is a relatively safe drug with a possible beneficial effect in the prophylaxis of migraine headache, and it may have its niche in the treatment of migraine patients. However, the current medical evidence that has accumulated and the fact that there are far more effective treatment possibilities clearly indicate that this drug is definitely not to be used by every migraineur.

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Oral Magnesium Oxide Prophylaxis of Frequent Migrainous Headache in Children: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Cited by 205 publications

References 43 publications

Why all migraine patients should be treated with magnesium

Why all migraine patients should be treated with magnesium

Rapid Resolution of Chronic Back Pain with Magnesium Glycinate in a Pediatric Patient

Should magnesium be given to every migraineur? No

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