Oral local drug delivery and new perspectives in oral drug formulation

Paderni, Carlo; Compilato, Domenico; Giannola, Libero Italo; Campisi, Giuseppina

doi:10.1016/j.oooo.2012.02.016

Cited by 108 publications

(68 citation statements)

References 73 publications

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“…Oral lesions can be effectively treated by topical therapeutic approaches, due to the ease of the oral cavity accessibility. However, formulations specifically designed for the treatment of oral mucosal diseases are few (Paderni et al, 2012), and most of these formulations were originally designed for dermatological application. Nevertheless, acquires a lot of limitations, whereas the oral cavity structural, environmental and functional features differ from that of the skin.…”

Section: Introductionmentioning

confidence: 99%

A new approach for treatment of precancerous lesions with curcumin solid–lipid nanoparticle-loaded gels: in vitro and clinical evaluation

et al. 2015

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Objective: Preparation and characterization of curcumin solid-lipid nanoparticle (CurSLN)-loaded mucoadhesive gel for local treatment of oral precancerous lesions with low dose. Methodology: The formulated CurSLNs were dispersed in a mucoadhesive gel matrix to be applied to the buccal mucosa. Conventional mucoadhesive gel using binary system was adopted. The prepared gels were evaluated for in vitro drug dialysis, ex vivo mucoadhesion test and ex vivo permeation study using chicken buccal mucosa. Short-term clinical evaluation was carried out on 10 patients suffering oral erythroplakia in terms of pain index and lesion size measurement.1 Results:The results showed that the loaded gel with CurSLN showed good mucoadhesion property and 25 min in vivo residence time. In addition to stability enhancement for the Cur powder. All formulae did not show any drug permeated, however, significant amount of Cur was retained within the chicken buccal mucosal tissue confirmed by histological examination. Significant reduction in pain, and complete healing was observed after 6 weeks of treatment. Conclusion:The local use of Cur in low dose is a promising option for treatment of precancerous lesions. The lack of local anti-inflammatory compounds with reduced side effects intensifies the importance of studying natural products for this purpose.

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Section: Introductionmentioning

confidence: 99%

A new approach for treatment of precancerous lesions with curcumin solid–lipid nanoparticle-loaded gels: in vitro and clinical evaluation

et al. 2015

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“…Moreover, the barrier function of oral mucosa prevents may hinder the absorption of the drug completely. [2,56] …”

Section: Advantages and Disadvantages/challenges Facedmentioning

confidence: 99%

Topical drug delivery: An essential aid in the management of oral diseases

Shastry¹,

Sanjay²,

Kaul³

et al. 2015

JCRI

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Topical medications play an important role in the management of oral lesions. Various topical medications ranging from topical anesthetics to topical antineoplastics have been widely used in dentistry. Topical medications have been extensively used as the first line of therapy in many conditions such as vesiculobullous diseases, oral infections like candidiasis, herpes simplex, potentially malignant disorders, neuropathic pain, and oral mucositis. Topical drug therapy provides targeted and a more efficient drug delivery options for the local oral lesions as compared to systemic therapy. While accessibility, lower systemic side effects, and many other advantages are associated with the usage of topical oral medications, several challenges are also faced such as taste alterations, poor penetration, and limited surface area. The objective of this review is to provide insight into the mechanism of topical drug delivery, summary of various topical medications used in oral lesions, advantages and disadvantages, characteristic of oral mucosa and various challenges faced in delivering topical medications.

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“…Symptomatic relief in patients may be partially attributed to mice nutrients contained in the immune milk powder [81] Oral Mucoadhesive Drugs: Mucoadhesive systems for oral local drug delivery include adhesive tablets, adhesive patches, adhesive films or pellicles, adhesive semisolid systems (Gels, ointments), and adhesive liquid systems (Sprays, mouthwashes). [82] Kumar NS et al reported semisolid mucoadhesive curcumin gel having antitumeric and antimutogenic property can be used for the treatment of oral sub mucous fibrosis which provides effect for extended periods of time. [83] Averineni RK et al conducted a preliminary study to develop mucoadhesive buccal films of valdecoxib a novel COX-2 inhibitor for the treatment of oral sub-mucous fibrosis.…”

Section: Cessation Of Habitmentioning

confidence: 99%

Recent Concepts of Etiopathogenesis and Management of Oral Submucous Fibrosis: A Review of Literature

Singh¹

2015

jemds

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Oral submucous fibrosis (OSF) is a well-recognized chronic insidious disease, precancerous condition, autoimmune and collagen related disorder which is multifactorial in origin mainly associated with the practice of chewing betel quid containing areca nut, a habit common among lower socio-economic strata of society. It is characterized by inflammation, increased deposition of submucosal collagen and formation of fibrotic bands in the oral and paraoral tissues, which increasingly limit mouth opening. In the myriad of literature available, numerous etiology and management techniques are put forward by various authors in the past. In this paper, an attempt is made to analyze critically and update the knowledge of the recent developments that enhances the understanding of the etiology of this premalignant condition and its medicinal & surgical management which improves the life expectancy.

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Oral local drug delivery and new perspectives in oral drug formulation

Cited by 108 publications

References 73 publications

A new approach for treatment of precancerous lesions with curcumin solid–lipid nanoparticle-loaded gels: in vitro and clinical evaluation

A new approach for treatment of precancerous lesions with curcumin solid–lipid nanoparticle-loaded gels: in vitro and clinical evaluation

Topical drug delivery: An essential aid in the management of oral diseases

Recent Concepts of Etiopathogenesis and Management of Oral Submucous Fibrosis: A Review of Literature

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