Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow‐up analysis

Yahalom, Ran; Yarom, Noam; Shani, Tali; Amariglio, N.; Kaplan, Ilana; Trakhtenbrot, Luba; Hirshberg, Abraham

doi:10.1002/hed.24086

Cited by 6 publications

(3 citation statements)

References 49 publications

(127 reference statements)

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“…The included studies comprised 54 cohorts; 48 of them harbored a retrospective design [19,, and 6 were prospective [5,17,[73][74][75][76]. A total of 24,277 patients were included: 22,578 with OLP, 717 with OLL, 153 with LMD, and 829 patients in one study without differentiating OLP and OLL [72].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Rate of Malignant Transformation Differs Based on Diagnostic Criteria for Oral Lichenoid Conditions: A Systematic Review and Meta-Analysis of 24,277 Patients

Chan

et al. 2023

Cancers

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Objectives: This systematic review and meta-analysis aims to evaluate the evidence on the malignant potential of oral lichenoid conditions (OLCs) including oral lichen planus (OLP), oral lichenoid lesions (OLL), and lichenoid mucositis dysplasia (LMD). In addition, it aims to compare the rate of malignant transformation (MT) in OLP patients diagnosed according to different diagnostic criteria, and to investigate the possible risk factors for OLP MT into OSCC. Materials and methods: A standardized search strategy was applied across four databases (PubMed, Embase, Web of Science, and Scopus). Screening, identification and reporting followed the PRISMA framework. Data on MT were calculated as a pooled proportion (PP), subgroup analyses and possible risk factors for MT were pooled as odds ratios (ORs). Results: Among 54 studies with 24,277 patients, the PP for OLCs MT was 1.07% (95% CI [0.82, 1.32]). The estimated MT rate for OLP, OLL and LMD was 0.94%, 1.95% and 6.31%, respectively. The PP OLP MT rate using the 2003 modified WHO criteria group was lower than that using the non-2003 criteria (0.86%; 95% CI [0.51, 1.22] versus 1.01%; 95% CI [0.67, 1.35]). A higher odds ratio of MT was observed for red OLP lesions (OR = 3.52; 95% CI [2.20, 5.64]), smokers (OR = 1.79; 95% CI [1.02, 3.03]), alcohol consumers (OR = 3.27, 95% CI [1.11, 9.64]) and those infected with HCV (OR = 2.55, 95% CI [1.58, 4.13]), compared to those without these risk factors. Conclusions: OLP and OLL carry a low risk of developing OSCC. MT rates differed based on diagnostic criteria. A higher odds ratio of MT was observed among red OLP lesions, smokers, alcohol consumers, and HCV-positive patients. These findings have implications for practice and policies.

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Section: Study Characteristicsmentioning

confidence: 99%

“…Malignant transformation rate by related risk factors. Forest plots for odds ratios of the association between OLP malignant transformation and gender[19,[27][28][29][30][31][32][33][34]36,37,39,41,42,44,45,48,[50][51][52][53][54]59,60,62,[67][68][69][70][71][73][74][75][76].…”

mentioning

confidence: 99%

Rate of Malignant Transformation Differs Based on Diagnostic Criteria for Oral Lichenoid Conditions: A Systematic Review and Meta-Analysis of 24,277 Patients

Chan

et al. 2023

Cancers

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“…Comparing cases of OLP with and without dysplasia, there was higher risk in those with dysplasia (3/44 vs 1/206) (Shearston et al, 2019). Apart from dysplasia, there are no established predictive biomarkers, although there are a few observational studies suggesting chromosomal aberrations (Yahalom et al, 2016) and aneuploidy (Sperandio et al, 2016) might be employed to identify high-risk patients.…”

Section: Or Al LI Chen Pl An Us and Or Al Lichenoid Le S Ionsmentioning

confidence: 99%

Management of oral potentially malignant disorders

Kerr

Lodi

2021

Oral Diseases

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Patients with oral potentially malignant disorders (OPMDs), including oral leukoplakia and erythroplakia, proliferative verrucous leukoplakia, oral submucous fibrosis, and oral lichen planus/lichenoid lesions, can be challenging to manage. A small proportion will undergo cancer development and determining a patient's cancer risk is key to making management decisions. Yet, our understanding of the natural history of OPMDs has not been fully elucidated, and a precision approach based on the integration of numerous predictive markers has not been validated by prospective studies. Evidence-based health promotion by clinicians and healthcare systems is not embraced universally. Medical and surgical interventions evaluated by rigorous research measuring important endpoints, such as cancer development, mortality, or survival, are difficult and expensive to run. Most of these studies employ non-ideal surrogate endpoints and have deep methodologic flaws. Diagnostic criteria for enrolling research subjects are not uniform, and patients with the highest risk for cancer development comprise small proportions of those enrolled. Few studies explore quality of life and patient preferences. It is time to rethink how we approach the management of these patients, across each OPMD, and considering the healthcare infrastructure and cost-effectiveness. Global networks with well-characterized patient populations with OPMDs and well-designed interventional trials using validated outcome measures are needed.

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Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis

et al. 2019

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Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow‐up analysis

Cited by 6 publications

References 49 publications

Rate of Malignant Transformation Differs Based on Diagnostic Criteria for Oral Lichenoid Conditions: A Systematic Review and Meta-Analysis of 24,277 Patients

Rate of Malignant Transformation Differs Based on Diagnostic Criteria for Oral Lichenoid Conditions: A Systematic Review and Meta-Analysis of 24,277 Patients

Management of oral potentially malignant disorders

Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis

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