Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis

González‐Moles, Miguel Ángel; Ruiz‐Ávila, Isabel; González‐Ruiz, Lucía; Ayén, Ángela; Gil-Montoya, José Antonio; Ramos‐García, Pablo

doi:10.1016/j.oraloncology.2019.07.012

Cited by 181 publications

(243 citation statements)

References 95 publications

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“…In the current study, one case of OSCC (1.3%) was found in OLP biopsy. This is in accordance with a recent metaanalysis reporting that malignant transformation of OLP was determined in 1.14% of cases [18].…”

Section: Discussionsupporting

confidence: 93%

Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies – a 6-year retrospective study

Kuzio

Wapniarska

Danilewicz

et al. 2020

J Pre Clin Clin Res.

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Introduction. Leukoplakia and oral lichen planus (OLP) are common diseases manifesting as white lesions that are considered potentially malignant disorders (PMD). Epithelial dysplasia may be an early sign of potency for the future transformation into oral squamous cell carcinoma (OSCC). A routine biopsy and close observation are recommended for persistent white oral lesions. As frictional keratosis may mimic oral leukoplakia, the question arises:Is there a need for a biopsy of persistent white lesion of traumatic origin? Materials and methods. Data from 643 oral tissue biopsies were retrospectively analyzed. A total of 176 (27.37%) results with provisional diagnosis of leukoplakia (36 cases), OLP (77 cases) and frictional keratosis (63 cases) were selected. Retrospective data collected included age, gender, smoking status, provisional and histopathological diagnosis. The data was analyzed to assess the prevalence of epithelial dysplasia and OSCC in terms of age, gender and smoking status. Results. Five (2.84%) cases of OSSC were reported, all of them were graded as G1; four cases of OSCC were found in clinically defined leukoplakia lesions; one case of OSCC (1.3%) was found in OLP biopsy; epithelial dysplasia was reported in 5 lesions (2.84%) provisionally diagnosed as OLP (3 cases), and leukoplakia in 2 cases. No dysplasia or OSCC were found in the lesions diagnosed as frictional keratosis. Conclusions. Epithelial dysplasia and OSCC may be found in leukoplakia or OLP lesions not initially suspected of any malignancy. In some cases, clinical features are not sufficient to diagnose a lesion without histopathology. Frictional keratosis is easily identified by clinicians, and may not require a biopsy in every case. Clinical and histopathological evaluation of the white lesions still needs improvement.

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Section: Discussionsupporting

confidence: 93%

Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies – a 6-year retrospective study

Kuzio

Wapniarska

Danilewicz

et al. 2020

J Pre Clin Clin Res.

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“…Among them, oral lichen planus (OLP) has a high prevalence 3 and the malignancy rate is underestimated. 4 OLP is a chronic mucocutaneous disorder with different kinds of clinical forms and may develop into OSCC. Thus, the process of OSCC tumorigenesis from OLP should be fully investigated.…”

Section: Introductionmentioning

confidence: 99%

<p>The circ-AMOTL1/ENO1 Axis Implicated in the Tumorigenesis of OLP-Associated Oral Squamous Cell Carcinoma</p>

Liu¹,

Yang²,

Sun³

et al. 2020

CMAR

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Background: Oral squamous cell carcinoma (OSCC) may develop from a variety of oral potentially malignant disorders, but the mechanism of malignant transformation is still unknown. Among them, oral lichen planus (OLP) has a high prevalence. Previous studies have shown that α-enolase (ENO1) can promote cell proliferation and play an important role in tumorigenesis. In this study, we aim to explore the mechanism of ENO1 regulation in the process of OSCC tumorigenesis from OLP. Methods: ENO1 expression in tissues was determined by real-time quantitative PCR and immunohistochemistry. ENO1 was knocked down in cal-27 to observe the change in cell proliferation. Then, RNA-seq and bioinformatics analyses were conducted between OLP and OSCC samples. The expression of circ-AMOTL1, miRNA-22-3p, and miRNA-1294 was assessed using the real-time quantitative PCR. With knockdown and overexpression of circ-AMOTL1 in vitro, the change of ENO1 in the mRNA level was also assessed. Results: ENO1 was enhanced in the OSCC samples in comparison with OLP. Immunohistochemistry and real-time quantitative PCR results showed that ENO1 was significantly higher in OSCC tissue than in the OLP group, with a statistically significant difference (p<0.05). When ENO1 was knocked down in cal-27, cell proliferation was inhibited (p<0.05). The expression of miR-22-3p and miR-1294 was decreased in OSCC tissues, whereas ENO1 and circ-AMOTL1 increased. In an in vitro study, knockdown of circ-AMOTL1 resulted in a decrease of ENO1, while overexpression of circ-AMOTL1 led to an increase of ENO1 in the mRNA level. Conclusion: We confirmed that ENO1 expression was elevated in OSCC and increased cell proliferation. In an in vitro study, ENO1 expression was promoted by circ-AMOTL1. ENO1 may play a role as a tumor-promoting gene in OSCC through the circ-AMOTL1/miR-22-3p/ miR-1294 network. These novel findings may shed further light on the pathogenesis from OLP to OSCC and the potential precursor markers.

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“…Oral lichen planus (OLP) is a common chronic inflammatory disease involving oral mucosa of probable immune-based etiology, 1 characterized by subepithelial bandlike infiltration of lymphocytes and liquefactive degeneration of the basal keratinocytes. 1 OLP often severely affects the patients' quality of life due to a protracted clinical course despite various available treatments [2][3][4] and, in particular, the potential for malignant transformation, 5,6 Currently, inflammation-related cytokines have been reported to be involved in the pathogenesis of OLP. 7 Thus, the research on the effects of the cytokines involved in the immunopathogenesis of OLP is important to explore novel therapeutic approaches of OLP compared to steroid treatment.…”

Section: Introductionmentioning

confidence: 99%

Altered expression of CCN1 in oral lichen planus associated with keratinocyte activation and IL‐1β, ICAM1, and CCL5 up‐regulation

Wang

Shi

et al. 2020

J Oral Pathology Medicine

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Background: Emerging evidence indicates that CCN1 is a novel inflammation-regulated mediator involved in the pathogenesis of some immune-mediated inflammatory diseases. The objective of this study was to investigate the preliminary roles of CCN1 and its related cytokines IL-1β, CCL5, and ICAM1 in oral lichen planus (OLP). Methods: CCN1 expression levels in biopsies from OLP patients against normal oral mucosa (NOM) using immunohistochemistry (42 OLP vs 9 NOM) and RT-qPCR (20 OLP vs 20 NOM) were compared, respectively. The correlation of CCN1 and IL-1β, CCL5, and ICAM1 expression was examined by RT-qPCR in tissue samples and an in vitro cell culture system using keratinocyte HaCaT cells incubated with lipopolysaccharides. Results: Immunohistochemistry showed that CCN1 protein mainly expressed in the cytoplasm of epithelial keratinocytes of OLP. Consistently, RT-qPCR revealed that mRNA expression of CCN1 was increased in OLP compared with NOM (P < .05) and positively correlated with the high expression of IL-1β, ICAM1, and CCL5 (P < .001), respectively. Importantly, an in vitro study showed that keratinocyte proliferation significantly (P < .05) increased by CCN1 stimulation. Moreover, IL-1β, ICAM1, and CCL5 expression in keratinocytes stimulated by CCN1 was increased (P < .05), respectively. Conclusions: This preliminary study for the first time reported that altered expression of CCN1 was associated with high expression of IL-1β, ICAM1, and CCL5 in OLP. And we demonstrated CCN1 promoted keratinocyte activation, as well as IL-1β, ICAM1, and CCL5 production in keratinocytes. Our data indicated that the potential role of CCN1 and its related cytokines was involved in the pathogenesis of OLP.

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Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis

Cited by 181 publications

References 95 publications

Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies – a 6-year retrospective study

Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies – a 6-year retrospective study

<p>The circ-AMOTL1/ENO1 Axis Implicated in the Tumorigenesis of OLP-Associated Oral Squamous Cell Carcinoma</p>

Altered expression of CCN1 in oral lichen planus associated with keratinocyte activation and IL‐1β, ICAM1, and CCL5 up‐regulation

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