Oral Lichen Planus: Novel Acquisitions in the Pathogenesis and Treatment

Abstract

Lichen planus (LP) is a mucocutaneous disease of chronic inflammatory nature, commonly seen in dermatological and dental clinics; it is a relatively common disorder of stratified squamous epithelia, frequently exclusively involving the oral cavity. Oral Lichen Planus (OLP) is often asymptomatic, the atrophic-erosive form can cause symptoms ranging from burning sensation to severe pain, interfering with speaking, eating, and swallowing. Lichen planus is regarded as a premalignant lesion. This review discusses the role of hepatitis C virus (HCV), bacterial and fungal infection in LP. Analysing the seroprevalence of HCV infection in LP patients and patients with oral OLP in particular, which was the case in the vast majority of studies, the association varied from 0% to 62% and seemed to be connected to the high HCV seroprevalence in the general population. Candida albicans is present in about 37% of oral LP lesions. The aim of this review is to summarize what is new in the pathogenesis and treatment of OLP.

The Relation Between Loss of a Family Member and Oral Lichen Planus in Iraqi Population

“…[14]; this could be explained through that the stressors have multiple effects on the body autonomic, nervous system, hormone levels, and brain activity. Perception and reaction to stressors are mediated by psychological factors [50], [51]. These factors can either trigger onset of the disease or cause existing disease to worsen [6].…”

“…most of the patients in this study gave the first duration time for their lesion eruption about 38 subjects from the all 58 patients had duration equal or less than 6months for discovering their lesions which was about (65%) of patients. And about 22 subjects of this duration time were giving a history of trouble before eruption of lesion (58%) in contrast of (29%) of subjects were had loss one dear person history before eruption of lesion as appear in figure (2) on other hand the majority of this duration time belong to the second age group of patients (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59).…”

“…Age And Gender The Sample age ranged from 26 to 73years with mean 48.37 ±SD12.26 and were categorized into three age groups (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39); (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59) and (60-79) the most common age group among the patients in this study was(4o-59) about 52%of all patients fallowed by third age group (60-79) was about 26%, lowest number of patients lied in the first age group (20-39) which was about 22%.as shown in figure (1) There was ahigh significant relationship between age group and patients classification group according to stressor events were told by patients which was about (0.005) as shown in Table no.1 . The female /male ratio included in this study.…”