Oral Lichen Planus in Patients with Chronic Liver Diseases*

Friedrich, Reinhard E; Heiland, Max; Doğan, Ali; Schrenck, T. von; Löning, T.

doi:10.1007/s15010-003-4074-5

Cited by 18 publications

(11 citation statements)

References 27 publications

(31 reference statements)

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“…In Japan, Italy, Nigeria, Thailand (Nagao et al, 1995;Carrozzo et al, 1996;Figueiredo et al, 2002;Daramola et al, 2003;Klanrit et al, 2003;Lodi et al, 2004), the prevalence of HCV infection in OLP patients ranging from 8.33% to 60% was statistically higher than the controls. However, reports from other areas, such as Holland,Germany, Serbia, Rio de Janeiro (van der Meij et al, 2000;Friedrich et al, 2003;Bokor-Bratic et al, 2004;Cunha et al, 2005) showed no difference in the HCV infection rate between the patients with OLP and the common population. In this study, we investigated the prevalence of HCV in 232 ethnic Chinese OLP patients and no association was found between these two diseases.…”

Section: Discussionmentioning

confidence: 94%

The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

et al. 2010

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Aim Oral lichen planush (OLP) is a chronic inflammatory disease, and has been reported to have a correlation with hepatitis C virus (HCV) infection in some regional investigations. In this study, we investigated the prevalence of HCV in patients with oral lichen planus in an ethnic Chinese cohort. Methodology The antibody of HCV infection was detectedby using enzyme-linked immunosorbent assay. Moreover, the clinical characteristics of whole the cohort have also been studied, such as the gender, age, clinical type, habits and social factors. ResultsOf all 232 patients, the antibody of HCV infection was detected positive in 4 patients (1.72%) using enzymelinked immunosorbent assay. It was lower than that in control group of 2.5%, but not significant (P=0.309). The positive rate of HCV antibody in the erosive type ones (4.2%) was higher than that in the reticular type ones (1.0%), but this difference was proved to be not significant (P=0.389). The clinical characteristics of whole cohort, such as the gender, age, clinical type, habits and social factors, showed the outcome obtained in the present study were similar to thao of our previous study.Conclusion HCV may play no etiological role in oral lichen planus in ethnic Chinese OLP patients.

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Section: Discussionmentioning

confidence: 94%

The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

et al. 2010

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“…Prevalence rates of HCV infection in OLP vary significantly by geography, ranging from 20% in Spain to as high as 62% in Japan (49,50). However, several studies of OLP patients in Northern and Western Europe have shown no association (51–55). Prospective laboratory evaluation for liver abnormalities in 195 consecutive OLP patients in the midwestern United States revealed no cases of hepatitis B or C virus infection or other liver abnormality (5).…”

Section: Lpmentioning

confidence: 99%

Section: Diagnostic Evaluationmentioning

confidence: 99%

Lichen planus and lichenoid reactions of the oral mucosa

Schlosser

2010

Dermatologic Therapy

132

188

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Oral lichenoid reactions represent a common end point in response to extrinsic agents (drugs, allergens), altered self-antigens, or superantigens. Oral lichen planus, a common and under-recognized inflammatory disorder, shares many clinical and histopathological features with oral lichenoid drug reaction and oral lichenoid contact reaction. Clinical presentation can vary from asymptomatic white reticular striae to painful erythema and erosions. Cutaneous and additional mucosal involvement is common. Delay in diagnosis of extraoral mucocutaneous lichen planus (LP) results in conjunctival scarring; vaginal stenosis; vulvar destruction; and stricture of the esophagus, urethra, and external auditory meatus. Although the etiology of LP is idiopathic, oral lichenoid reactions may be caused by medications or exogenous agents such as cinnamates and other flavorings. The clinical features, evaluation, and management of these oral lichenoid reactions are discussed.

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“…The association of OLP with both HCV infection and liver disease appears to be partially dependent on geographic factors. Some, but not all studies of American patients (Eisen, 2002a), as well as British (Ingafou et al , 1998), Irish (Roy et al , 2000), Dutch (van der Meij and van der Waal, 2000), and German (Grote et al , 1999; Friedrich et al , 2003) patients failed to demonstrate an association between LP and liver abnormalities. However, in studies from countries with a high HCV prevalence (Egypt and Nigeria), there were negative or insignificant associations with OLP, suggesting that a LP‐HCV association cannot always be explained on the basis of high prevalence in the general population (Carrozzo and Gandolfo, 2003).…”

Section: Etiology and Associationsmentioning

confidence: 99%

Number V Oral lichen planus: clinical features and management

Eisen¹,

et al. 2005

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Oral lichen planus (OLP) is a relatively common chronic inflammatory disorder affecting stratified squamous epithelia. Whereas in the majority of instances, cutaneous lesions of lichen planus (LP) are self-limiting and cause itching, oral lesions in OLP are chronic, rarely undergo spontaneous remission, are potentially premalignant and are often a source of morbidity. Current data suggest that OLP is a T cell-mediated autoimmune disease in which auto-cytotoxic CD8+ T cells trigger apoptosis of oral epithelial cells. The characteristic clinical aspects of OLP may be sufficient to make a correct diagnosis if there are classic skin lesions present. An oral biopsy with histopathologic study is recommended to confirm the clinical diagnosis and mainly to exclude dysplasia and malignancy. The most commonly employed and useful agents for the treatment of lichen planus (LP) are topical corticosteroids but other newer agents are available.

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Oral Lichen Planus in Patients with Chronic Liver Diseases*

Abstract: Our results show that there is no increased prevalence of OLP manifestation in patients suffering from HCV infection.

Cited by 18 publications

References 27 publications

The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

Lichen planus and lichenoid reactions of the oral mucosa

Number V Oral lichen planus: clinical features and management

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