The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

Zhou, Yu; Jiang, Lu; Liu, Jie; Zeng, Xin; Chen, Qianming

doi:10.4248/ijos10028

Cited by 23 publications

(16 citation statements)

References 21 publications

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“…Several studies 14,15,16,17 have investigated the relationships between different species of viruses and OLP. However, very few, if any, studies have examined the relationship between bacteria and OLP.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Various medicines and chemicals may cause OLP or OLP-like reactions 11 Virusesthat play a role in the etiology of OLP include the herpes viruses, especially the Epstein–Barr Virus, 14 human papillomavirus, 15 and hepatitis C virus (HCV). 16,17 Although it has been determined that OLP and viruses are related, the roles of bacteria in the etiology of OLP have not yet been determined. However, it is known that OLP is related to periodontal diseases.…”

Section: Introductionmentioning

confidence: 99%

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Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

et al. 2013

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Oral lichen planus (OLP) is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 (18 chronic periodontitis (OLPP) and 9 gingivitis (OLPG)) patients diagnosed with OLP along with 26 (13 chronic periodontitis (HP) and 13 gingivitis (HG)) healthy non-OLP patients. The multiplex polymerase chain reaction (PCR) with subsequent reverse hybridization method (micro-IDent) was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients (OLPG and OLPP) were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients (HG and HP), these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens' percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathogenic microorganisms in the progress of periodontal diseases of OLP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

et al. 2013

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“…There are six variants of OLP which include papular, reticular, plaque-like, atrophic, erosive, and bullous disease. Erosive mucosal disease is most problematic given the pain associated with the disease and can lead to oral candidiasis as well as carry premalignant risk [51,52]. Occasionally, the only identifying clue in OLP can be the sole presence of Wickham's striae.…”

Section: Lichen Planusmentioning

confidence: 98%

Cutaneous Manifestations of Viral Hepatitis

Ahmed

Said

2015

Curr Infect Dis Rep

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There are several extrahepatic cutaneous manifestations associated with hepatitis B and hepatitis C virus infection. Serum sickness and polyarteritis nodosa are predominantly associated with hepatitis B infection, whereas mixed cryoglobulinemia associated vasculitis and porphyria cutanea tarda are more frequently seen in hepatitis C infection. The clinico-pathogenic associations of these skin conditions are not completely defined but appear to involve activation of the host immune system including the complement system. Management of the aforementioned cutaneous manifestations of viral hepatitis is often similar to that done in cases without viral hepatitis, with control of immune activation being a key strategy. In cases associated with hepatitis B and C, control of viral replication with specific antiviral therapy is also important and associated with improvement in most of the associated clinical manifestations.

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“…Important previously published meta-analyses were also included, such as those by Lodi et al (2004), Shengyuan et al (2009), Lodi, Pellicano andCarrozzo (2010), among others (Birkenfeld et al, 2011;Lin, Lu, & Lu, 2010;Halawani, Balbisi, Alotaibi, Alsaif, & Bakir, 2010;Zhou, Jiang, Liu, Zeng, & Chen, 2010;Rübsam et al, 2011). Analysis of 64 articles detected that patients with OLP had 5.58 times more chances of having a concomitant infection by HCV when compared to control population (Gorouhi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

<b>Association between oral lichen planus and hepatitis C: retrospective study and case report

Silva

Jacomacci

Borges

et al. 2017

Acta Sci. Health Sci.

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ABSTRACT. Oral Lichen Planus (OLP), a chronic inflammatory disease of unknown etiology, which affects the skin and/or mucosal tissues, is an autoimmune disease (pathology) of special interest to dentists due to its oral manifestations and its possible association with Hepatitis C virus (HCV). Although a possible association has been extensively discussed in the literature, the results have been controversial. So that the relationship between Oral Lichen Planus (OLP) and infection by HCV (OLP-HCV) may be investigated, current study conducted an epidemiological survey of all OLP cases diagnosed in two reference projects, with regard to diagnosis, treatment and epidemiology of oral lesions in Maringá, Paraná, Brazil. In addition, the clinical case of a patient with HCV and the clinical manifestation of severe OLP will be provided. A total of 3,488 clinical records of biopsies performed between 1994 and 2014 and 85 cases of OLP were selected for the present study. The reticular type of OLP showed significant prevalence but only 2.3% of OLP cases revealed any association with HCV.Palavras-chave: líquen plano, hepatite C, epidemiologia.Associação entre líquen plano oral e hepatite C: estudo retrospectivo e relato de caso RESUMO. Líquen Plano (LP) é uma doença inflamatória crônica de etiologia desconhecida, que acomete pele e/ou mucosas. Esta doença autoimune é de especial interesse para o cirurgião-dentista pelo fato de apresentar manifestações bucais e pode estar associado ao vírus da hepatite C (VHC). Esta possível associação tem sido muito discutida na literatura, apresentando resultados controversos. Com o intuito de investigar a relação entre o Líquen Plano Oral (LPO) e a infecção pelo VHC (LPO-VHC), o presente trabalho objetivou conduzir um levantamento de todos os casos de LPO diagnosticados em dois projetos de referência quanto a diagnóstico, tratamento e epidemiologia de lesões bucais na cidade de Maringá, Paraná, Brasil. Adicionalmente, um caso clínico de um paciente portador do VHC com manifestação clínica severa de líquen plano será apresentado. Foram selecionados para o presente estudo um total de 3.488 prontuários de biópsias realizadas entre os anos de 1994 e 2014 e 85 casos de LPO. O LPO do tipo reticular apresentou prevalência estatisticamente significante e apenas 2.3% dos casos de LPO apresentaram associação com o VHC.

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The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

Cited by 23 publications

References 21 publications

Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

Cutaneous Manifestations of Viral Hepatitis

<b>Association between oral lichen planus and hepatitis C: retrospective study and case report

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