Oral immunization of sows: Anti‐K88 antibodies in serum and milk of the sow and in serum of the piglets

Kortbeek-Jacobs, Netty; Houten, M. van

doi:10.1080/01652176.1982.9693833

Cited by 3 publications

(5 citation statements)

References 10 publications

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“…In the present study the Ig-class specific anti-KS8 antibody titres, as determined in serum of two day old piglets, appeared to be a reflection of the antibody profile in colostrum. This is in accordance with the observations of Yabiki et al (1974) and Kortbeek-Jacobs and van Houten (1982). An overall reduction of the serum immunoglobulins to about 504 was observed in ten day old piglets.…”

Section: Anti-k88 Variant Specificitysupporting

confidence: 82%

“…Concerning oral vaccination, Gibbons et al (1977) postulated that sows lacking the receptor for K88-positive bacteria do not recognize these bacteria as an antigen and do not produce antibodies to K88 to the same extent as adhesion-positive sows. Later studies supported these suggestions (Sellwood, 1979;Kortbeek-Jacobs and van Houten, 1982). Therefore, adhesion-positive offspring of a phenotype E sow will not be protected by colostral and milk antibodies.…”

Section: Introductionsupporting

confidence: 53%

“…Experimental studies have demonstrated that intestinal colonization of the sow prepartum (Bohl et al, 1972;Kortbeek-Jacobs and van Houten, 1982) or during lactation (Evans et al, 1980) will selectively stimulate a specific IgA response in mammary secretions. In the present experimental design colonization was imitated by the administration of large quantities of live K88-positive E.coli culture for a prolonged period.…”

Section: Anti-k88 Variant Specificitymentioning

confidence: 99%

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K88 variants K88ab, K88ac and K88ad in oral vaccination of different porcine adhesive phenotypes. Immunological aspects

Bijlsma

Houten

Frik

et al. 1987

Veterinary Immunology and Immunopathology

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Bijlsma, I.G.W., van Houten, M., Frik, J.F., and Ruitenberg, E.J., 1987. K88 variants K88ab, K88ac and K88ad in oral vaccination of different porcine adhesive phenotypes. Immunological aspects. Vet.lmmunol.lmmunopathol.,16: 235-25D.Sows of different adhesive phenotypes were vaccinated orally during the last 4 weeks of gestation with K88-positive Escherichia coli. Sows susceptible to adhesion by the K88 variant of the vaccination strain produced a significant IgA-class specific anti-K88 response in colostrum and milk and post-farrowing serum. Indications for an IgM and IgG-class specific anti-K88 response were also found in this group but only in milk. In sows resistant to adhesion by the K88 variant of the vaccination strain only an IgA-class specific anti-KS8 antibody response was found in mammary secretions and in post-farrowing sera, but titres did not reach the high values of the former group. The response in the second group was attributed to the frequent administration of large quantities of K88-positive E.coli which to some extent can be compared with a colonization effect. Specificity for the serological components of the K88 variants was detectable in colostral IgA of sows susceptible to the vaccination strain only.

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Section: Anti-k88 Variant Specificitysupporting

confidence: 82%

Section: Introductionsupporting

confidence: 53%

Section: Anti-k88 Variant Specificitymentioning

confidence: 99%

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K88 variants K88ab, K88ac and K88ad in oral vaccination of different porcine adhesive phenotypes. Immunological aspects

Bijlsma

Houten

Frik

et al. 1987

Veterinary Immunology and Immunopathology

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“…leptospires) (Pike, 1967;Crawford, 1972;Bey and Johnson, 1978a;Adler et al, 1980) so that the MAT titre in itself does not allow conclusions to be drawn about the class of antibody concerned and, consequently, about the stage of the disease. The ELISA technique has been used to identify the specific classes of immunoglobulin (IgM or IgG) which are produced against various pathogenic micro-organisms (Voller et al, 1978;Adler et al, 1980;Kortbeek-Jacobs and van Houten, 1982). In the present paper results are reported of the detection of specific anti-leptospiral IgM and IgG in the serum of dogs experimentally infected with Leptospira interrogans serotype canicola using an ELISA technique developed by the present authors.…”

Section: Introductionmentioning

confidence: 74%

“…This method is to some extent comparable with the ELISA technique described in the present paper. The ELISA was used previously in identifying specific classes of immunoglobulin directed against various pathogenic micro-organisms in several animal species and in man (Voller et al, 1978;Adler et al, 1980;Kortbeek-jacobs and van Houten, 1982). Following experimental infection of dogs with L. interrogans serotype canicola, specific anti-leptospiral IgM was already detectable by the end of the first week after infection using the ELISA technique, and the titre subsequently showed a rapid increase.…”

Section: Resultsmentioning

confidence: 99%

Determination of specific anti-leptospiral immunoglobulins M and G in sera of experimentally infected dogs by solid-phase enzyme-linked immunosorbent assay

Hartman

Houten

Donk

et al. 1984

Veterinary Immunology and Immunopathology

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Vaccines for preventing enterotoxigenic Escherichia coli infections in farm animals

Moon

Bunn

1993

Vaccine

166

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Fimbrial vaccines are routinely given parenterally to pregnant cattle, sheep and swine to protect suckling newborn calves, lambs and pigs against enterotoxigenic Escherichia coli (ETEC) infections. Such vaccines are practical and effective because (1) most fatal ETEC infections in farm animals occur in the early neonatal period when the antibody titres in colostrum and milk are highest; (2) more than 90% of the ETEC in farm animals belong to a small family of fimbrial antigen types; (3) fimbriae consist of good protein antigens on the bacterial surface where they are readily accessible to antibody; (4) fimbriae are required for a critical step (adhesion-colonization) early in the pathogenesis of the disease. ETEC infections continue to be a significant clinical problem in farm animals in spite of extensive use of fimbriae-based vaccines. Definitive data on the efficacy of the commercial vaccines in field use are not available. The prevailing perception among animal health professionals is that the vaccines are effective, that the problem occurs chiefly among non-vaccinated animals, and that in some herds vaccination moves peak prevalence of disease from the first to the second or third week after birth, when mortality is lower. It has been suggested that extensive use of vaccines will rapidly select for the emergence of novel or previously low prevalence fimbrial antigen types. There is no evidence that this has happened after a decade of routine vaccine use in the United States. However, there is no active direct surveillance for such emergence.(ABSTRACT TRUNCATED AT 250 WORDS)

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Oral immunization of sows: Anti‐K88 antibodies in serum and milk of the sow and in serum of the piglets

Cited by 3 publications

References 10 publications

K88 variants K88ab, K88ac and K88ad in oral vaccination of different porcine adhesive phenotypes. Immunological aspects

K88 variants K88ab, K88ac and K88ad in oral vaccination of different porcine adhesive phenotypes. Immunological aspects

Determination of specific anti-leptospiral immunoglobulins M and G in sera of experimentally infected dogs by solid-phase enzyme-linked immunosorbent assay

Vaccines for preventing enterotoxigenic Escherichia coli infections in farm animals

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