Oral hypoglycaemic plants in West Africa

Bever, Bep Oliver

doi:10.1016/0378-8741(80)90005-7

Cited by 46 publications

(16 citation statements)

References 3 publications

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“…Furthermore, Babu et al . [24], during their investigation on the antidiabetic activity of Cassia klenii leaves using isolation of an active fraction, reported that the antihyperglycemic activity of the Cassia klenii plant was found predominantly in the chloroform fraction of the alcohol extract, which contained terpenoids, coumarins and saponins. Acting separately or synergistically, sinensitin and other compounds present in the Cƒ2-B fraction isolated during this study could be responsible for the antihyperglycemic effect of Cƒ2-B.…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic Effect of Orthosiphon Stamineus Benth Leaves Extract and Its Bioassay-Guided Fractions

Mohamed

Asmawi

et al. 2011

Molecules

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Preliminary investigations were carried out to evaluate the antidiabetic effects of the leaves of O. stamineus extracted serially with solvents of increasing polarity (petroleum ether, chloroform, methanol and water); bioassay-guided purification of plant extracts using the subcutaneous glucose tolerance test (SbGTT) was also carried out. Only the chloroform extract, given at 1 g/kg body weight (b.w.), significantly reduced (P < 0.05) the blood glucose level of rats loaded subcutaneously with 150 mg/kg (b.w.) glucose. The active chloroform extract of O. stamineus was separated into five fractions using a dry flash column chromatography method. Out of the five fractions tested, only chloroform fraction 2 (Cƒ2), at the dose of 1 g/kg (b.w.) significantly inhibited (P < 0.05) blood glucose levels in SbGTT. Active Cƒ2 was split into two sub-fractions Cƒ2-A and Cƒ2-B, using a dry flash column chromatography method. The activities Cƒ2-A and Cƒ2-B were investigated using SbGTT, and the active sub-fraction was then further studied for anti-diabetic effects in a streptozotocin-induced diabetic rat model. The results clearly indicate that Cƒ2-B fraction exhibited a blood glucose lowering effect in fasted treated normal rats after glucose-loading of 150 mg/kg (b.w.). In the acute streptozotocin-induced diabetic rat model, Cƒ2-B did not exhibit a hypoglycemic effect on blood glucose levels up to 7 hours after treatment. Thus, it appears that Cƒ2-B functions similarly to metformin, which has no hypoglycemic effect but demonstrates an antihyperglycemic effect only in normogycemic models. The effect of Cƒ2-B may have no direct stimulatory effects on insulin secretion or on blood glucose levels in diabetic animal models. Verification of the active compound(s) within the active fraction (Cƒ2-B) indicated the presence of terpenoids and, flavonoids, including sinensitin.

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Section: Discussionmentioning

confidence: 99%

Antihyperglycemic Effect of Orthosiphon Stamineus Benth Leaves Extract and Its Bioassay-Guided Fractions

Mohamed

Asmawi

et al. 2011

Molecules

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“…The compounds were found to show activity by oxidizing large amounts of glucose, thus causing a decrease of liver glycogen and a drop of glucose to hypoglycemic levels. 82 Acer pycnanthum: Ginnalin A (21) obtained from A. pycnanthum exhibited potent α-glucosidase inhibitory activity. The results suggest that α-glucosidase inhibition is influenced by the number of galloyl groups.…”

Section: Sapindaceaementioning

confidence: 99%

A Review on Anti-diabetic Plants

Qais

Jahan

Shajib

2018

Dhaka Univ. J. Pharm. Sci

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Diabetes mellitus is a common metabolic disorder whose prevalence is rapidly increasing all over the world. According to WHO, diabetes will be the seventh leading cause of death in 2030. Since long back, plants have been used to heal or combat illness and are the source of many modern medicines. In view of the above aspects, the present review provides information about the antidiabetic plants, available through literature source from various database. From the present study it is evident that most of the plants having anti-diabetic properties belong to the family Moraceae, Cucurbitaceae, Liliaceae, Anacardiaceae, Myrtaceae, Fabaceae, Solanaceae, Asteraceae and many others. The hypoglycemic activities are contained in different parts of these plants like leaf, rhizomes, fruits, bark, seeds or other parts which differ from species to species. It is also evident from this review that the mode of action and dosage of administration differs from plant to plant.

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“…Oliver22 listed glycosides, flavonoids, tannins, alkaloids, coumarins, triterpenes, organic sulphur compounds and saponins as active hypoglycemic compounds. Hence the presence of reported constituents in the present study in the extracts may be responsible for hypoglycemic activity observed.…”

mentioning

confidence: 99%

Antidiabetic activity ofclerodendron phlomoidisleaf extract in alloxan-induced diabetic rats

Dhanabal¹,

Marugaraja²,

Suresh³

2008

Indian J Pharm Sci

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Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rats (120 mg/kg, i.p.) at two dose levels, viz., 100 and 200 mg/kg. The ethanol extract at 200 mg/kg dose level exhibited significant (p<0.05) hypoglycemic activity and also correction of altered biochemical parameters viz., cholesterol and triglycerides (p<0.05).

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Oral hypoglycaemic plants in West Africa

Cited by 46 publications

References 3 publications

Antihyperglycemic Effect of Orthosiphon Stamineus Benth Leaves Extract and Its Bioassay-Guided Fractions

Antihyperglycemic Effect of Orthosiphon Stamineus Benth Leaves Extract and Its Bioassay-Guided Fractions

A Review on Anti-diabetic Plants

Antidiabetic activity ofclerodendron phlomoidisleaf extract in alloxan-induced diabetic rats

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