Objectives: To evaluate the oral health knowledge, attitudes, and practices among secondary school students in the Al-Karak Governorate. Method: A cross-sectional school-based study was conducted from February to May 2012. Multi-stage random sampling was used. Six secondary public schools within Al-Karak Directorate were chosen randomly. Data was analysed using SPSS and P value was considered significant at 0.05. Results: The results show that the mean knowledge scores for the secondary school children was 60.8 with a statistically significant difference between male and female students (P<0.05). Nearly three-quarters of them reported that regular visits to the dentist are necessary. In contrast, nearly half of them visited the dentist regularly and nearly one fifth of them would only visit the dentist when they felt pain. Nearly 80% of them brushed their teeth with a toothbrush, and about 35.5% of them brushed their teeth at least twice a day or more. Conclusions: The findings of this study indicate that the mean knowledge score of the school students was poor. A health education programme to be integrated within the school curriculum emphasizing oral health is highly recommended.