“…In the elderly, the main cause of xerostomia is medication and, in particular, the use of ‡4-5 drugs per day [2]. More than 500 medications are associated with xerostomia, with special emphasis placed on psychotropic drugs (anticholinergic drugs/atropinics, neuroleptics, tricyclic antidepressants, antipsychotics, benzodiazepines), followed by anti-hypertensives, diuretics, anti-neoplastics, opiates, bronchodilatators, proton pump inhibitors, antihistamines and others [6][7][8][9]16,17]. However, few medications except for true anticholinergic drugs have been demonstrated to affect salivary function and polypharmacy remains the most prevalent cause of mouth dryness [4,14,16].…”