Oral health in children with chronic kidney disease

Velan, Elizabeth; Sheller, Barbara

doi:10.1007/s00467-020-04913-9

Cited by 18 publications

(27 citation statements)

References 45 publications

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“…In a preceding project [35], children with congenital heart diseases showed a higher prevalence of bacteremia after toothbrushing (21.4%) and also a greater caries prevalence with a mean DMFT of 4.6. Patients with CKD show lower caries prevalence, e.g., due to the alkaline oral pH that protects against acidogenic microflora associated with caries [40]. Whether or not caries influences the trespassing of bacteria into the blood stream is yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…The increased plaque levels and gingivitis indices at baseline demonstrate inadequately performed oral hygiene measures prior to dental instruction and prophylaxis measures. Even in high-risk transplant patients, a demand-oriented preventive dental service can lead to an improvement in oral hygiene at home and thus improve the local inflammatory process in the oral cavity [40].…”

Section: Discussionmentioning

confidence: 99%

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The impact of a needs-oriented dental prophylaxis program on bacteremia after toothbrushing and systemic inflammation in children, adolescents, and young adults with chronic kidney disease

et al. 2021

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Background Chronic kidney disease (CKD) still leads to high mortality rates, mainly due to cardiovascular disease. One important influencing factor is persisting low-grade chronic inflammation partly maintained by gingivitis that favors transient bacteremia during daily activities such as toothbrushing. Methods To examine whether intensive dental prophylaxis can restore oral health, reduce the prevalence of bacteremia and degree of systemic inflammation indicated by CRP levels, we conducted this pilot study examining 30 CKD patients aged 6–26 years, 15 receiving intensive prophylaxis (IP), 15 receiving treatment as usual (TAU) serving as control group. There were three appointments for examination, each 10 ± 1 weeks apart (at baseline, after intervention periods one and two, when TAU also received IP, and the IP group stopped prophylaxis). Results The gingival index (GI) in the IP group decreased by 90% (GI 0.09; p=0.001), resulting in almost healthy gingiva. There was no significant change in CRP or prevalence of bacteremia. General prevalence of bacteremia after toothbrushing was 9.5% affecting 7 (26%) of the participants. In three participants, bacteremia dissolved after IP, in one after TAU. Two patients developed bacteremia ≥ 10 weeks after ending IP. We identified eight different bacterial species. Conclusions We were able to show that IP can effectively treat gingivitis. It might be a promising approach to reduce systemic inflammation and subsequently lower premature cardiovascular disease, despite the lack of statistical significance. Future research requires a larger patient cohort to enable matched treatment groups with long-term follow-up and molecular detection methods for bacteremia. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The impact of a needs-oriented dental prophylaxis program on bacteremia after toothbrushing and systemic inflammation in children, adolescents, and young adults with chronic kidney disease

et al. 2021

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“…Thus, children and adolescents with a kidney transplant need dental care on a routine basis as there are oral findings related to some underlying diseases and to the transplantation itself and immunosuppressive therapy. Caries, gingivitis and dental developmental disorders can further compromise their well‐being and overall health after the kidney transplantation as certain medications can induce gingival overgrowth (eg nifedipine) and cause painful oral ulcerations (eg everolimus), and may increase the patient's susceptibility to oral Candida infections (eg immunosuppressant medications) 6 …”

Section: Introductionmentioning

confidence: 99%

“…Caries, gingivitis and dental developmental disorders can further compromise their well-being and overall health after the kidney transplantation as certain medications can induce gingival overgrowth (eg nifedipine) and cause painful oral ulcerations (eg everolimus), and may increase the patient's susceptibility to oral Candida infections (eg immunosuppressant medications). 6 A few studies have addressed oral findings in kidney transplant children and adolescents. Farge et al 7 assessed the oral needs of 106 kidney transplant children and found enamel defects in 34.9% of them.…”

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confidence: 99%

Oral findings in kidney transplant children and adolescents

Tuma

Andrade

Antunes

et al. 2022

Int J Paed Dentistry

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Kidney transplantation in children was first performed early in the 1970s, and the rate of success for this type of treatment increased over time until becoming the best therapeutic option for children and adolescents with terminal chronic renal failure (TCRF). The mortality rate of paediatric patients with TCRF on dialysis is seven times higher than that of kidney transplant patients. In addition, kidney transplantation leads to adequate skeletal growth, neurocognitive development and maturation and better quality of life in children and adolescents compared with those on dialysis. [1][2][3] In Brazil, the public healthcare system funds 95% of kidney transplantations, with the country ranking second in the world regarding such a procedure, second only to the United States. In 2019, a total of 6283 kidney transplantations were performed in Brazil, of which 310 were in patients younger than 18 years old. 4 According to the Brazilian Transplant Registry, congenital and hereditary diseases are the primary causes of renal failure in children from birth to 4 years old. Between the ages of 5 and 14 years, renal failure is mostly caused by hereditary conditions, nephrotic syndrome and systemic diseases, whereas the main underlying diseases are congenital anomalies of the kidneys and the urinary tract (CAKUT) (40.5%) and glomerulopathy (28%). 5

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“…It is thought to be caused by ameloblasts that have been affected by local and systemic factors during the formation of enamel [1]. Studies have reported on eruption disorders in patients with developmental enamel defects other than MIH [2,3]. The eruption is a dynamic process that begins at the initial positioning of the tooth in the alveolar bone and continues until the final positioning at which it is occluded by a dental antagonist.…”

Section: Introductionmentioning

confidence: 99%

Timing of clinical eruption of permanent teeth in children with molar incisor hypomineralization

Şenyurt¹,

Hazar

Demiriz

2022

Srp Arh Celok Lek

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Introduction/Objective. Molar incisor hypomineralization (MIH) is a developmental defect and it has a multifactorial etiology, there could be variations in dental eruptions in the children with this condition. The aim of this study was the comparison of the clinical eruption status of the permanent teeth of children with MIH and patients without MIH. Methods. The study group comprised a total of 300 children (176 females and 124 males aged 6-12) who had been diagnosed with MIH but had no systemic disease. The control group comprised 300 age- and sex-matched children without MIH. In the study and control groups, the eruption of the permanent tooth (excluding third molars) was evaluated and compared. In addition, this comparison was performed separately for the males and females in the study and control groups. The independent samples t-test was used for statistical analysis. Results. No statistically significant difference was found between the mean age of the dental eruptions of the children with MIH and that of the children without mineralization disorders (p > 0.05). Regarding the mean age of the dental eruptions, the gender-matched comparison revealed no statistically significant difference between the study and control groups (p > 0.05). Conclusion. Although there was no statistically significant difference in the MIH and healthy control group regarding the mean age of the eruption of all teeth, a trend of accelerated dental development in the MIH group was observed.

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Oral health in children with chronic kidney disease

Cited by 18 publications

References 45 publications

The impact of a needs-oriented dental prophylaxis program on bacteremia after toothbrushing and systemic inflammation in children, adolescents, and young adults with chronic kidney disease

The impact of a needs-oriented dental prophylaxis program on bacteremia after toothbrushing and systemic inflammation in children, adolescents, and young adults with chronic kidney disease

Oral findings in kidney transplant children and adolescents

Timing of clinical eruption of permanent teeth in children with molar incisor hypomineralization

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