Oral Glucose Tolerance and Related Factors in a Normal Population Sample--II. Interrelationship of Glycerides, Cholesterol, and other Factors with the Glucose and Insulin Response

Abrams, M. E.; Jarrett, R. J.; Keen, H.; Boyns, D. R.; Crossley, J. N.

doi:10.1136/bmj.1.5644.599

Cited by 76 publications

(19 citation statements)

References 23 publications

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“…Chiang et al (14) have reviewed 31 studies from all parts of the world that showed positive correlation between overweight and hypertension and 19 that showed reduction in blood pressure consequent upon weight reduction. Two excellent reports have similarly documented the relationship of obesity to diabetes with its attendant hypercholesterolemia (1,6).…”

Section: Health Consequences Of Obesity and Of Weight Reductionmentioning

confidence: 91%

Presidential Address-1974: From Explanation to Action in Psychosomatic Medicine: The Case of Obesity

Stunkard

1975

Psychosomatic Medicine

162

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Psychosomatic medicine began as a social movement within medicine, designed to counteract the mechanistic and impersonal features that had accompanied the introduction of science into medical education. In its early days, therapeutic inefficacy led to a concentration upon understanding the origins of disorders in which emotional determinants played a role. To a large exten, psychosomatic medicine is still identified with such understanding. Within recent years, however, the development of increasingly effective therapeutic techniques has changed the emphasis in psychosomatic medicine from understanding to action. These developments are particularly well exemplified by the case of obesity. Social investigations have revealed that the prevalence of obesity within populations is determined to a very high degree by social factors, operating in an unplanned and uncontrolled manner...

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Section: Health Consequences Of Obesity and Of Weight Reductionmentioning

confidence: 91%

Presidential Address-1974: From Explanation to Action in Psychosomatic Medicine: The Case of Obesity

Stunkard

1975

Psychosomatic Medicine

162

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“…This contention is supported by the highly significant association between internal cation imbalance and elevated triglycerides and urate. Elevated triglycerides are a prominent characteristic of hyperinsulinemia and insulin resistance, 25 ' x which are accompanied by overproduction of very low density lipoproteins. 26 An association of elevated triglycerides with altered cation transport mechanisms has recently been reported and hypothesized to reflect the effect of changes in plasma lipid levels on cellular membrane composition.…”

mentioning

confidence: 99%

Altered erythrocyte and plasma sodium and potassium in hypertension, a facet of hyperinsulinemia.

et al. 1988

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SUMMARY Red blood cell sodium and potassium, plasma potassium, glucose and insulin responses to oral glucose load, serum urate, and plasma triglycerides were determined in a stratified subsample (n = 89) of a representative population sample (n= 1211), comprising 30 nonobese normotensive subjects with normal glucose tolerance (reference group) and 59 subjects representing each of the seven possible combinations of abnormal glucose tolerance, obesity, and hypertension. Rate of cation imbalance (red blood cell sodium > 7.0 mEq/L, potassium < 92.5 mEq/L, or plasma potassium > 4.5 mEq/L) was 88.1% in subjects with abnormal tolerance, obesity, or hypertension, as compared with 40.0% in the reference group (p< 0.001). These subjects were also characterized by significantly greater rates of insulin response: 60-and 120-minute postload levels of 100 mU/L or more (88.1 vs 46.7%), plasma triglycerides of 80 mg/dl or more (89.8 vs 53.3%) and serum uric acid of 5.5 mg/dl or more (61.0 vs 26.7%; p < 0.001 for all). The rate of cation imbalance was significantly associated with each of these three biochemical correlates: insulin response (p<0.01), triglycerides (p< 0.001), and urate (p< 0.001). In the total population sample, the rate of untreated hypertension increased from 18% to 35% to 55.3% (p<0.001), with an increase in the number of biochemical correlates of cation imbalance in combination with glucose intolerance and obesity. Since insulin is a regulator of membrane cation transport, whereas abnormal glucose tolerance, obesity, and hypertension, as well as elevated serum urate and triglycerides, are correlates of hyperinsulinemia and insulin resistance, we conclude that hyperinsulinemia is implicated in the cation transport abnormalities that characterize hypertension, obesity, and glucose intolerance. 6 Essential hypertension has recently been shown to be characterized by hyperinsulinemia, a long-known feature of obesity and glucose intolerance, where it reflects insulin resistance.

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“…The degree of control o~ hyperglycemia has been reported to influence serum lipids [3,4] and the majority of patients with elevated level of very low density lipoproteins (VLDL) in plasma exhibit abnormal glucose tolerance [5]. Little association, however, has been noted between the levels of plasma insulin and plasma cholesterol [6].…”

mentioning

confidence: 99%

Cholesterol metabolism in the diabetic Chinese hamster

et al. 1974

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Oral Glucose Tolerance and Related Factors in a Normal Population Sample--II. Interrelationship of Glycerides, Cholesterol, and other Factors with the Glucose and Insulin Response

Cited by 76 publications

References 23 publications

Presidential Address-1974: From Explanation to Action in Psychosomatic Medicine: The Case of Obesity

Presidential Address-1974: From Explanation to Action in Psychosomatic Medicine: The Case of Obesity

Altered erythrocyte and plasma sodium and potassium in hypertension, a facet of hyperinsulinemia.

Cholesterol metabolism in the diabetic Chinese hamster

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