Oral formulations of the selective serotonin3 antagonists ramosetron (intraoral disintegrator formulation) and granisetron hydrochloride (standard tablet) in treating acute chemotherapy-induced emesis, nausea, and anorexia: A multicenter, randomized, single-blind, crossover, comparison study

Feng, Feng Yi; Zhang, Pin; He, Yi; Li, Yu Hong; Zhou, Mei Zhen; Cheng, Gang; Chen, Yan; Kikkawa, Tomoko; Yamamoto, Masakazu

doi:10.1016/s0011-393x(02)80093-5

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…The discovery of 5-hydroxytryptamine 3 (5-HT3) receptors in afferent vagal nerve fibers and in neurons in the gastrointestinal tract suggested that chemotherapeutic agents such as cisplatin may induce the release of 5-HT3 in the SAMIA A. NOUR, et al, small intestine, thereby initiating nausea and vomiting by stimulating the vagus nerve. Therefore, blockage of 5-HT3 receptors in the small intestine by 5-HT3 receptor antagonists might prevent the initiation of this reflex (1) . Some of 5-HT3 receptor antagonists are available world wide in oral and intravenous dosage forms only and are used in the prevention and therapy of nausea and vomiting associated with cancer chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Fractional Factorial Design Approach for Studying in Vitro Transdermal Delivery of Granisetron Using Electroporation

Nour

Elewa

El-rehim

2008

Al-Azhar Bulletin of Science

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Granisetron Hydrochloride is a 5-hydroxytryptamine 3 (5-HT3) receptor antagonist used for the prevention and treatment of nausea and vomiting associated with cancer chemotherapy. Based on the hydrophilicity of this drug (pka=9.4) it is unlikely that passive diffusion across the skin could deliver therapeutic amounts from a large sized patch. This study was conducted to evaluate the feasibility of in vitro transdermal delivery of granisetron using electroporation across full thickness hairless rat skin. A 2 4-1 fractional factorial design was used to determine the most important variables affecting the transdermal delivery of granisetron using electroporation. The variables studied and respective levels investigated were drug concentration (10, 20 mg/ml), voltage (155, 310 volt), pulse duration (12, 24 ms) and number of pulses (100, 200 pulses). Permeation profiles were used for the representation of data, where Q: the cumulative amount permeated per cm 2 (µg/cm 2) was plotted against time (min). The selected dependent variable (response) was Q120 which is the cumulative amount permeated per cm 2 after 2 hours. Design-expert version 7.0.0 was used for the statistical evaluation. The results of the analysis of variance (ANOVA) revealed that Q120 was significantly affected by the voltage, pulse duration and number of pulses. The drug concentration had a non significant effect on Q120. A reduced polynomial regression equation which expresses the influence of process parameters on the response was obtained to enable navigation of the experimental space.

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Section: Introductionmentioning

confidence: 99%

Fractional Factorial Design Approach for Studying in Vitro Transdermal Delivery of Granisetron Using Electroporation

Nour

Elewa

El-rehim

2008

Al-Azhar Bulletin of Science

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Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood

Phillips

Gopaul

Gibson

et al. 2010

Cochrane Database of Systematic Reviews

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Analysis 3.1. Comparison 3 Ondansetron vs Granisetron, Outcome 1 Complete control of acute nausea.. .. . Analysis 3.2. Comparison 3 Ondansetron vs Granisetron, Outcome 2 Complete control of acute vomiting.. .. . Analysis 3.3. Comparison 3 Ondansetron vs Granisetron, Outcome 3 Complete control of delayed nausea.. .. . Analysis 3.4. Comparison 3 Ondansetron vs Granisetron, Outcome 4 Complete control of delayed vomiting.. . .

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Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood

Phillips

Friend

Gibson

et al. 2016

Cochrane Database of Systematic Reviews

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show abstract

Oral formulations of the selective serotonin3 antagonists ramosetron (intraoral disintegrator formulation) and granisetron hydrochloride (standard tablet) in treating acute chemotherapy-induced emesis, nausea, and anorexia: A multicenter, randomized, single-blind, crossover, comparison study

Cited by 6 publications

References 10 publications

Fractional Factorial Design Approach for Studying in Vitro Transdermal Delivery of Granisetron Using Electroporation

Fractional Factorial Design Approach for Studying in Vitro Transdermal Delivery of Granisetron Using Electroporation

Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood

Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood

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