Oral Exposure to Silver/Gold Nanoparticles: Status of Rat Lipid Profile, Serum Metabolites and Tissue Morphology

Abstract

Study investigated the effect of oral administration of gold-silver nanoparticles on rat biochemical parameters and tissue morphology. Wistar rats weighing approximately 180±7 g were randomly assigned into four groups. Animals in the control group received distilled water once daily for 30 days while, those in the treatment groups were administered 10, 50 and 100 mg kgG 1 b.wt. gold-silver nanoparticles. The rats were sacrificed under slight anesthesia, 24 h after the last treatments. Blood and vital organs including the heart, kidney and liver were collected and prepared for biochemical and histopathological determinations. Exposure to Ag/Au nanoparticles altered the rat serum lipid profile; lowering the HDL-C while raising the atherogenic index. Exposure of Ag/Au nanoparticles in rats caused significant alteration to the levels of serum albumin, total protein, bilirubin, urea and creatinine. The activities of alanine transaminase, aspartate transaminase and alkaline phosphatase in rat serum and tissues were also significantly altered by Ag/Au nanoparticles exposure. The histopathological examination revealed inflammation and cellular degeneration caused by exposure to the Ag/Au nanoparticles. We show evidence that Ag/Au nanoparticles elevated atherogenic index, as well as caused biochemical and morphological alterations, reminiscent of cellular injury.

Curcumin incorporated titanium dioxide nanoparticles as MRI contrasting agent for early diagnosis of atherosclerosis- rat model

“…Same way, reports state that TNPs administration could not elicit toxic changes in the histopathology of the rat. Our results are comparable with the previous reports ( Sulaiman et al., 2015 ).…”

Histological and biochemical effects of Cinnamomum cassia nanoparticles in kidneys of diabetic Sprague-Dawley rats

“…In control group A, rats received normal saline (1 mL) orally once per day. Group B rats were orally administered with CcAgNPs at low dose (5 mg/kg), once per day [7]. Group C rats were orally administered with CcAgNPs at high dose (10 mg/kg), once per day [7].…”

“…Group B rats were orally administered with CcAgNPs at low dose (5 mg/kg), once per day [7]. Group C rats were orally administered with CcAgNPs at high dose (10 mg/kg), once per day [7]. Group D rats were administered with C. cassia plant extract at 200 mg/kg.…”

“…Silver (Ag) is the metal of choice for the application of NPs in biology and medicine. AgNPs have been used as anticancer, antiangiogenic, and antibacterial agents [6][7][8]. Moreover, they can be used to treat diseases that require a sustained release of a drug at several anatomical sites [9].…”

Cellular apoptosis of HFF cells by inorganic nanoparticles not susceptible to modulation by Toxoplasma gondii infection in vitro

“…AgNPs have been implicated for cytotoxic efficacy applicable in cancer therapy (Azizi et al, 2017). AuNPs are inert and biocompatible and these have been applied as theranostics as well as for phototherapy (Moses et al, 2016;Rieznichenko et al, 2012) while PtNPs are noted for antioxidant properties that mimic catalase and superoxide dismutase (Sulaiman et al, 2015;Adeyemi et al, 2018a). As a further testament of the increasing popularity of NPs for biomedical applications, the potential of NPs against Toxoplasma gondii infection was recently reported (Adeyemi et al, 2017a;Adeyemi et al, 2017b).…”