Oral erosive lichen planus with epidermolytic hyperkeratosis during interferon alfa-2b therapy for chronic hepatitis C virus infection

Schlesinger, Todd; Camisa, Charles; Bergfeld, Wilma F.

doi:10.1016/s0190-9622(97)80296-4

Cited by 26 publications

(19 citation statements)

References 16 publications

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“…In this sense, Schlesinger et al (10) described a case of OLP that started in a patient treated with interferon alfa-2b and Griffiths et al (8) stated that interferon can induce the expression of surface antigens on keratinocytes, which may play an important role in the origin of lichen planus. Still, for Sookoian et al (9), ribavirin increases the risk of adverse skin reactions, among them the OLP (11,12).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

et al. 2014

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The objective of this study was to evaluate the cellular proliferative potential of oral lichen planus (OLP) lesions from patients without hepatitis C virus (HCV) by means of AgNOR method, as well as the cellular proliferative potential of the normal oral mucosa from patients with HCV, treated or untreated by interferon and ribavirin. A cross-sectional study was developed to investigate four groups: 10 HCV+ patients without clinical signs of OLP who had never been treated for HCV infection -Group 1; 10 HCV+ patients that were under interferon and ribavirin treatment -Group 2; 15 patients with reticular OLP lesions histopathologically confirmed, without HCV -Group 3; and 15 blood donors without HCV infection and no clinical signs of OLP GROUP 4 Control Group. The cytological material of all groups was collected by the liquid-based cytology technique. Then, the sedimented material from each patient was filled with the Nucleolar Organizer Regions impregnation by silver method (AgNOR). The count of NORs was performed on 100 epithelial cell nuclei per patient using the Image Tool™ software. The Tukey HSD test was used to compare the median value of NORs among the groups and showed that the oral mucosa of HCV+ patients previously treated with anti-HCV drugs (GROUP 2), presented a higher average number of NORs in relation to others (p<0.05). The anti-HCV treatment may be related to increased cell proliferation of oral mucosa, indicating a possible relationship between OLP and HCV+ patients treated with interferon and ribavirin.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

et al. 2014

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“…There has been 1 prior report describing the onset of OLL with IFN and ribavirin therapy in HCV-monoinfected subjects. [7][8][9][10][11][12][13][14][15][16][17][18] Considering these case reports (Table 1), it is important to note that the diagnostic criteria followed by the authors for discriminating OLP from OLL (and from OLDR in particular) are not always clearly stated because some of them arise after anti-HCV therapy. It is advisable, as we already stated, that clear diagnostic criteria be followed to diagnose OLP or OLL; the article of Van der Meij and van der Waal 3 is worth considering.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] Some researchers describe the onset and/or the worsening of OLL/OLP after the administration of anti-hepatitis C virus (HCV) therapy. [7][8][9][10][11][12][13][14][15][16][17][18] We describe the development of symptomatic OLLs, after the administration of anti-HCV therapy, in 2 human immunodeficiency virus (HIV)-HCVcoinfected subjects.…”

Section: Introductionmentioning

confidence: 99%

Oral Lichenoid Lesions in HIV-HCV-Coinfected Subjects During Antiviral Therapy: 2 Cases and Review of the Literature

Giuliani¹,

Lajolo²,

Sartorio³

et al. 2008

The American Journal of Dermatopathology

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Some dental materials and certain drugs may induce epithelial alterations, which clinically resemble oral lichen planus (OLP), on oral mucosa. But these alterations do not have all the clinical and/or the histological features of OLP; these lesions are known as oral lichenoid lesions (OLLs). Some researchers describe the onset and/or the worsening of OLL/OLP after the administration of anti-hepatitis C virus (HCV) therapy. In this article, we describe the development of symptomatic OLLs, as a consequence of anti-HCV therapy (interferon-alpha and ribavirine), in 2 human immunodeficiency virus-HCV-coinfected subjects. An immunological cause related to coinfection and administration of different medications could be responsible for the onset of OLLs. These new cases, together with the previous reports of a possible association between OLP and/or OLL and anti-HCV therapy, highlight the absolute need to monitor carefully the human immunodeficiency virus-HCV-coinfected subjects who are about to start the anti-HCV therapy and to define better the clinical and histopathological criteria to distinguish OLP from OLL.

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“…Interferon alfa-2a and -2b have been used to treat heapatitis caused by the hepatitis C virus. Both interferon alfa-2a and -2b have been reported to either initiate [26, 27, 28]or exacerbate [29, 30]lichen planus lesions following this therapy for infection with hepatitis C virus. On the contrary, other publications describe clearance [31]or no effect [32]using interferon alfa-2a on oral lichen planus.…”

Section: Discussionmentioning

confidence: 99%

Kaposi’s Sarcoma in a Patient with Erythroblastopenia and Thymoma: Reactivation after Topical Corticosteroids

et al. 1998

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We report a 69-year-old female with erythroblastopenia and thymoma who developed lesions of Kaposi’s sarcoma (KS) after thymectomy, 2 months after the initiation of therapy with methylprednisolone. Control of mucocutaneous KS lesions was obtained with radiotherapy, interferon alfa-2b and withdrawal of systemic immunosuppressive therapy. Erosive oral lichen planus appeared later, and after therapy with topical corticosteroids a new lesion of KS developed that regressed after withdrawal of topical corticosteroids. The detection of HHV-8 only in lesional skin supports the hypothesis that this virus can trigger the development of KS lesions.

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Oral erosive lichen planus with epidermolytic hyperkeratosis during interferon alfa-2b therapy for chronic hepatitis C virus infection

Cited by 26 publications

References 16 publications

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

Oral Lichenoid Lesions in HIV-HCV-Coinfected Subjects During Antiviral Therapy: 2 Cases and Review of the Literature

Kaposi’s Sarcoma in a Patient with Erythroblastopenia and Thymoma: Reactivation after Topical Corticosteroids

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