Oral Elastofibromatous Lesions: A Review and Case Series

Darling, Mark; Kutalowski, Maciej; MacPherson, David G.; Jackson-Boeters, Linda; Wysocki, George P.

doi:10.1007/s12105-011-0274-y

Cited by 15 publications

(23 citation statements)

References 17 publications

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Section: Casementioning

confidence: 99%

“…Elastofibroma and elastofibromatous lesion of the oral cavity are tumor‐like lesions composed of elastic and fibrous connective tissue, which may represent a reactive process associated with friction irritation or trauma . Several cases of oral elastofibroma and oral elastofibromatous lesion have been published. The differential diagnosis for these oral lesions included localized fibrous hyperplasia, irritation or traumatic fibroma, and fibroepithelial polyp, as well as leukoplakia .…”

Section: Casementioning

confidence: 99%

“…Several cases of oral elastofibroma and oral elastofibromatous lesion have been published. The differential diagnosis for these oral lesions included localized fibrous hyperplasia, irritation or traumatic fibroma, and fibroepithelial polyp, as well as leukoplakia . In the current cases, similar to the latter, an oral white lesion was observed, which microscopically showed abundant elastic fibers interposed with scarce collagen fibers, confirmed by Verhoeff‐Van Gieson stain, mainly exhibiting nonbranched fibers and/or globular configuration, and occasionally a “test‐tube brush” arrangement, different from the typical histopathological features seen in elastofibroma dorsi .…”

Section: Casementioning

confidence: 99%

“…Since the publication of Potter et al, few oral cases of elastofibroma, hyperelastosis, and elastofibromatous lesions have been reported in the literature . Notably, to date, four cases clinically presenting as leukoplakia, and microscopically diagnosed as elastofibromatous changes, have been published .…”

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Elastofibromatous lesion as a differential diagnosis of white lesions of the oral mucosa

et al. 2019

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periadnexal and perivascular infiltrate of predominantly lymphocytes with some plasma cells, later followed by adnexal atrophy, loss of periadnexal fat, and marked dermal sclerosis. Morphea profunda extends deep into subcutaneous issue and shows predominantly septal panniculitis with septal fibrosis, fat replacement, and aggregates of lymphoplasmacytic infiltrate. 10,11 Postirradiation pseudosclerodermatous panniculitis is a rare condition usually presenting as an indurated plaque with the histomorphology of lobular panniculitis with prominent septal fibrosis, adiponecrosis, lipophagic granulomata, and chronic inflammatory infiltrate of foamy histiocytes with rare lymphocytes and plasma cells. 12,13 Another consideration is lupus panniculitus. Histopathologically, lupus panniculitis is a predominantly lobular lymphocytic panniculitis with hyaline fat necrosis and lymphoplasmacytic aggregates 8,14 While eosinophils can be present in the inflammatory infiltrates of morphea and lupus panniculitis, the characteristic morphological features of these entities were not seen in our case.In summary, we describe a case of panniculitis with fat necrosis and numerous eosinophils, which was associated with AFG. After considering other possibilities, hypersensitivity reaction to substances released by adipocytes during fat necrosis or inflammatory cytokines may have been a culprit; however the underlying etiology of this manifestation remains uncertain. Awareness of this potential complication of AFG is important due to its clinical presentation mimicking recurrent malignancy, infection, and radiation dermatitides among others. ORCID Valentina Logunovahttps://orcid.org/0000-0001-6561-9806 ration and its later amendments or comparable ethical standards. INFORMED CONSENTInformed consent was obtained from all individual participants included in this study.

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Section: Casementioning

confidence: 99%

Section: Casementioning

confidence: 99%

Section: Casementioning

confidence: 99%

mentioning

confidence: 99%

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Elastofibromatous lesion as a differential diagnosis of white lesions of the oral mucosa

et al. 2019

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“…Furthermore, several cases presenting elastofibromatous changes in the oral mucosa have been reported in recent years (9)(10)(11)(12)(13)(14). As mentioned above, elastic fibers are also distributed around the vascular wall in the oral mucosal tissues and are speculated to be involved in the pathogenesis of OFH.…”

Section: Introductionmentioning

confidence: 98%

Histopathological and Immunohistochemical Studies of the Distribution of Elastic Fibers in Oral Fibrous Hyperplasia

Oshima

2014

Int J Oral-Med Sci

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Oral fibrous hyperplasias (OFH) are thought to result from hyperplasia of collagen fibers.However, details regarding the presence of elastic fibers and reticular fibers other than collagen fibers in OFH are unclear.Therefore, this study focused on elastic fibers in the connective tissue with regard to OFH, and assessed the histopathological, histochemical, and immunohistochemical distribution of the elastic fibers.All cases of OFH (120 cases) were performed Elastica van Gieson (EvG) staining, and the distribution of elastic fibers was assessed using image analysis (binarization). Cases were classified into 2 groups; one group with elastic fibers (EF+ group) and one group without elastic fibers (EF−group). Histopathologically, elastic fibers were observed with mingled hyperplastic collagen fiber bundles and extended in the lesion. The distribution quantity of elastic fibers was fibroma of labial mucosa and buccal mucosa, and there were fewer elastic fibers in fibrous epulis and fibromatous epulis. Immunohistochemically, spindle cells in all cases of OFH were diffusely positive for Vimentin and negative for Actin, and CD34-positive spindle cells were interspersed into the connective tissue in EF+ group. In conclusion, elastic fibers were observed in 57.5% of OFH cases. The distribution of these fibers was site-specific, and differed from the collagen fibers that constituted OFH. CD34 positivity was observed in the spindle cells constituting OFH accompanied by elastic fibers, and undifferentiated mesenchymal cells around myogenic blood vessels near the lesion were related to the formation of a part of elastic fibers that constituted OFH.

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Oral Cavity: Nonneoplastic and Benign Neoplasia

Brandwein‐Weber

2018

Textbook of Head and Neck Pathology

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Oral Elastofibromatous Lesions: A Review and Case Series

Cited by 15 publications

References 17 publications

Elastofibromatous lesion as a differential diagnosis of white lesions of the oral mucosa

Elastofibromatous lesion as a differential diagnosis of white lesions of the oral mucosa

Histopathological and Immunohistochemical Studies of the Distribution of Elastic Fibers in Oral Fibrous Hyperplasia

Oral Cavity: Nonneoplastic and Benign Neoplasia

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