Elastofibromatous lesion as a differential diagnosis of white lesions of the oral mucosa

Abstract

periadnexal and perivascular infiltrate of predominantly lymphocytes with some plasma cells, later followed by adnexal atrophy, loss of periadnexal fat, and marked dermal sclerosis. Morphea profunda extends deep into subcutaneous issue and shows predominantly septal panniculitis with septal fibrosis, fat replacement, and aggregates of lymphoplasmacytic infiltrate. 10,11 Postirradiation pseudosclerodermatous panniculitis is a rare condition usually presenting as an indurated plaque with the histomorphology of lobular panniculitis with prominent septal fibrosis, adiponecrosis, lipophagic granulomata, and chronic inflammatory infiltrate of foamy histiocytes with rare lymphocytes and plasma cells. 12,13 Another consideration is lupus panniculitus. Histopathologically, lupus panniculitis is a predominantly lobular lymphocytic panniculitis with hyaline fat necrosis and lymphoplasmacytic aggregates 8,14 While eosinophils can be present in the inflammatory infiltrates of morphea and lupus panniculitis, the characteristic morphological features of these entities were not seen in our case.In summary, we describe a case of panniculitis with fat necrosis and numerous eosinophils, which was associated with AFG. After considering other possibilities, hypersensitivity reaction to substances released by adipocytes during fat necrosis or inflammatory cytokines may have been a culprit; however the underlying etiology of this manifestation remains uncertain. Awareness of this potential complication of AFG is important due to its clinical presentation mimicking recurrent malignancy, infection, and radiation dermatitides among others. ORCID Valentina Logunovahttps://orcid.org/0000-0001-6561-9806 ration and its later amendments or comparable ethical standards. INFORMED CONSENTInformed consent was obtained from all individual participants included in this study.

Elastofibromatous changes in giant cell fibroma and amalgam tattoo: Unusual findings in common oral lesions

“…In the oral cavity, several cases diagnosed as elastofibromatous lesions or elastofibroma, clinically mimicking FH and leukoplakia, have been reported. Most cases appear to be strongly related to trauma or irritation 4,5 . Also, intraoral elastofibromatous changes affecting salivary gland neoplasms, epithelial dysplasia, carcinoma in situ, and non‐odontogenic cyst have been described, 4,9,10 with the current case expanding their clinicopatological spectrum.…”

“…Most cases appear to be strongly related to trauma or irritation. 4,5 Also, intraoral elastofibromatous changes affecting salivary gland neoplasms, epithelial dysplasia, carcinoma in situ, and nonodontogenic cyst have been described, 4,9,10 with the current case expanding their clinicopatological spectrum.…”

“…Amalgam tattoo (AT), also known as localized argyria or local argyrosis, forms as a result of entry of dental amalgam into the oral mucosa, frequently gingiva and alveolar ridge, clinically presenting as a gray or black area 2,3 . The connective tissue matrix in GCF and AT is well recognized and typical; however, we have recently observed large areas containing elastofibromatous changes 4,5 in these two lesions, which are very unusual findings.…”