Oral Disease in Man and Animals

Gorlin, Robert J.

doi:10.1001/archderm.1967.01610040040009

Cited by 20 publications

(8 citation statements)

References 28 publications

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“…This high frequency of the acanthomatous epulis might be due to the large population of the Shetland sheepdog, which was one of the breeds in which the acanthomatous epulis was most commonly found. Epulides were reported most often in brachycephalic dogs, such as boxers or Boston terriers [8,9]. Canine oral lesions similar to epulis, named "familial gingival hypertrophy," were reported in related boxer breeds [4].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of Canine Oral Epulides.

et al. 1999

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ABSTRACT. To clarify the clinicopathological features of canine epulides, 189 epulides were reviewed retrospectively. The incidence of the fibromatous, ossifying, acanthomatous and giant cell epulides were 56.6% (107/189), 23.3% (44/189), 18.0% (34/189) and 2.1% (4/189), respectively. The average ages of dogs with fibromatous, ossifying, acanthomatous and giant cell epulides were 8. 8, 8.4, 7.8 and 8.7 years, respectively. The male/female ratio of dogs with the acanthomatous epulis (0.8) was lower than those of dogs with the fibromatous (1.9), ossifying (1.4) and giant cell epulis (3.0). There were slight breed differences among the types of epulides. The most noticeable result was that 38.2% of the acanthomatous epulis occurred in Shetland sheepdogs. 43.9% of the fibromatous epulis and 52% of the ossifying epulides arose around maxillary premolars, while 58.8% of the acanthomatous epulis arose around the mandibular canines. Dogs with the fibromatous and ossifying epulides had more severe dental plaque deposition than those with the acanthomatous epulides. Few of the fibromatous (6/104) or ossifying epulides (4/44) showed recurrence after excision, while the majority (21/23) of the acanthomatous epulides showed rapid and repeated recurrences after surgical excision. Epulides treated with hemimandibulectomy or bleomycin chemotherapy did not recur. Giant cell epulides showed no recurrence after surgical removal. These results indicate that the acanthomatous epulis differed from other types of epulides in biological and morphological features and poor prognosis.-KEY WORDS: canine, clinicopathology, epulis.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of Canine Oral Epulides.

et al. 1999

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“…Cotchin ( 1966) and Gorlin and Peterson ( 1967) have suggested that a possible cause of this condition is exposure to a carcinogen when the cat is grooming itself with its tongue. This hypothesis is compatible with the location of the lesion.…”

Section: I50mentioning

confidence: 99%

Spontaneous squamous cell carcinomas of the oral region in domestic animals: a review and consideration of their relevance to human research

1996

Oral Diseases

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Spontaneous squamous cell carcinomas of the oral region in domestic animals have the potential of providing additional information about the pathology of oral cancer and may be useful in therapeutic research. Moreover, they exhibit definite advantages over chemically induced tumors in rodents. This article provides background information on spontaneous oral squamous cell carcinomas in dogs, cats, cattle, horses and sheep and then discusses the use in research of such tumors in dogs and cats. These two species are potentially the most useful because they are numerous, suffer quite commonly from squamous cell carcinoma of the oral cavity and oro‐pharynx, and are usually allowed to live approximately normal life spans. Moreover, they are being treated routinely in veterinary hospitals.

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“…3,28 Most mast cell tumors are relatively easy to diagnose in routinely processed tissues because of their morphology and staining characteristics. 3 However, poorly differentiated 10,23 or poorly fixed 13 mast cell tumors can be confused with other round cell tumors. 10,23 Misdiagnosis and failure to identify those tumors can result in a poor prognosis 3,28 and thus a lack of aggressive therapy.…”

mentioning

confidence: 99%

“…20 The specificity of several staining methods for mast cells 20 provides the pathologist with a useful means for the differential diagnosis of mast cell tumors. 10 Most stains for mast cells rely on the cell's content of heparin, other glycosaminoglycans (GAGs), 38 and esterases. 19 As an alternative to histochemical stains, different antibodies have been used to identify mast cells in humans, rodents, and dogs.…”

mentioning

confidence: 99%

Canine Mast Cell Tumors: A Comparison of Staining Techniques

Simões

Schoning

1994

J VET Diagn Invest

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Abstract. Twelve histochemical methods; affinity staining with avidin peroxidase, wheat germ agglutinin, and concavalin-A agglutinin; and an immunohistochemical stain with Kpl (CD68) antibody were compared for their relative effectiveness in staining canine mast cell tumors. Stains were compared in 28 mast cell tumors and 19 histiocytomas. The effectiveness of the histochemical methods and the lectins decreased as the mast cells became less differentiated. None of the staining methods were positive on histiocytomas. Periodic acidSchiff (PAS) gave positive results in a few cases of mast cell tumors where other histochemical stains were negative. Although avidin peroxidase and Kpl antibody stained more mast cell tumors than any other method, they did not differ significantly from Luna's method, toluidine blue pH 0.5, toluidine blue pH 4.5, alcian blue pH 2.5, safranin O, Unna's method, and Giemsa. No stain was ideal for the diagnosis of canine mast cell tumors; however, this study suggests that the use of avidin peroxidase, Kpl antibody, and PAS may give additional information for individual poorly differentiated tumors without substantial increase in time or cost.

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Oral Disease in Man and Animals

Cited by 20 publications

References 28 publications

Clinicopathological Study of Canine Oral Epulides.

Clinicopathological Study of Canine Oral Epulides.

Spontaneous squamous cell carcinomas of the oral region in domestic animals: a review and consideration of their relevance to human research

Canine Mast Cell Tumors: A Comparison of Staining Techniques

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