Oral Delivery of Pingyangmycin by Layer-by-Layer (LbL) Self-Assembly Polyelectrolyte-Grafted Nano Graphene Oxide

Liu, Yu; Han, Jiajing; Pan, Hao; Jia, Dechao; Chen, Lijiang; Yang, Xiaoyang

doi:10.1166/jnn.2019.16531

Cited by 4 publications

(3 citation statements)

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“…In recent years various forms of graphene oxide, especially its conjugated form with PEG has gained considerable attention and interest due to its unique physiochemical properties [46]. The functionalization of GO with PEG has been reported to improve the stability in aqueous solution and the biocompatibility, making it an ideal drug-delivery vehicle [47–48]. Rapid progress has been made in the synthesis of graphene oxide nanoparticles and their use in medicine, so there is an urgent need to look at the safety and efficacy of these particles in vivo.…”

Section: Discussionmentioning

confidence: 99%

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

Ain¹,

Haq²,

Alshammari³

et al. 2019

Beilstein J. Nanotechnol.

148

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Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites (PEG-nGO). Graphene oxide sheets (GOS) were synthesized via a modified Hummer's method and were characterized by X-ray diffraction (XRD), ultraviolet–visible spectroscopy (UV), and transmission electron microscopy (TEM). The method of Zhang was adopted for cracking of GOS. Then nano-graphene oxide was PEGylated with polyethylene glycol (PEG). PEGylation of nGO was confirmed by Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy and TEM. The average size distribution of nGO and PEG-nGO was determined by using dynamic light scattering (DLS). Subsequently, an in vivo study measuring a marker for oxidative stress, namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathione S-transferase was conducted. A comparison at different intervals of time after the administration of a dose (5 mg/kg) of PEG-nGO was carried out. An increase in free radicals and a decrease in free radical scavenging enzymes in organs were observed. Our results indicated that the treatment with PEG-nGO caused an increased OS to the organs in the first few hours of treatment. However, the liver completely recovered from the OS after 4 h. Brain, heart and kidneys showed an increased OS even after 4 h. In conclusion increased OS induced by PEG-nGO could be detrimental to brain, heart and kidneys.

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Section: Discussionmentioning

confidence: 99%

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

Ain¹,

Haq²,

Alshammari³

et al. 2019

Beilstein J. Nanotechnol.

148

View full text Add to dashboard Cite

show abstract

“…Above this size, they are prone to aggregation in the liver or the spleen, and, below that, they can suffer blood renal filtration, being filtered from the plasma to the urine [ 8 ]. When encapsulating or bonding a drug to its respective carrier, it is also important to consider the ratio of drug:carrier, as this can affect encapsulation/bonding efficiency [ 71 ].…”

Section: Graphene Oxide As Carrier In Drug Deliverymentioning

confidence: 99%

“…In recent years GO has gained a lot of attention for its potential use in biomedical applications, with several publications reporting its benefits as a drug in cancer therapy [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ]. For example, Liu et al [ 71 ] investigated a possible nanocarrier for oral drug administration in cancer treatment, developing a thin film with graphene as nanocarrier and pingyangmycin (PYM) as the anti-cancer drug of choice. Orally administered drugs have reduced side effects when compared with IV administration and are more easily accepted by the patients; however, they have some drawbacks, such as being easily degraded by the gastric acid and pepsin present in the stomach, low bioavailability, rapid clearance, and poor tissue distribution.…”

Section: Graphene Oxide As Carrier In Drug Deliverymentioning

confidence: 99%

Graphene Oxide Thin Films with Drug Delivery Function

et al. 2022

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Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.

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Studies of the interaction of graphene oxide (GO) with endothelial cells under static and flow conditions

Dabrowski,

Ulanowicz,

Brzozka

et al. 2024

Environmental Toxicology and Pharmacology

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Oral Delivery of Pingyangmycin by Layer-by-Layer (LbL) Self-Assembly Polyelectrolyte-Grafted Nano Graphene Oxide

Cited by 4 publications

References 0 publications

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

Graphene Oxide Thin Films with Drug Delivery Function

Studies of the interaction of graphene oxide (GO) with endothelial cells under static and flow conditions

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