Oral Contraceptives and Thromboembolic Disease

The Control and Surveillance of Systemic Contraceptives in Australia

“…Vessey (1968), Vessey and Doll (1969), and the results of the combined study of Inman et al (1970), the Drug Evaluation Committee has accepted that there may be an increased frequency of thrombo-embolism in women taking systemic contraceptives which may be related to the oestrogen content. In view of later papers (Poller et al 1971;Drill, 1972;Drill and Calhoun, 1972), the negative findings of a survey conducted by the Royal Australian College of General Practitioners and the recognised diaculty in achieving unbiased reporting, it still does not regard either as proved beyond doubt. Nevertheless the Committee has recommended that the preparation be prescribed containing the lowest dose of oestrogen which is both efficacious and acceptable to the patient.…”

Combination Oral Contraceptives and Cardiovascular Disease

“…The relationship of OCs to CVD has been the sub ject of many reviews [1][2][3][4][5][6][7][8][9][10][11][12][13] like this one because only a few years after their introduction, OCs were ac cused of causing embolic disease in some users. These early associations were publicized, debated in the scientific and lay media, and politicized; the at tention OCs gained early on has remained focused on them.…”