Oral Contraceptives and Cardiovascular Risk: Adding Clinical Evidence to the Pathophysiology

Kasal, Daniel A.; Lorenzo, Andrea De

doi:10.36660/ijcs.20200078

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Interestingly, the risk of hypertension associated with OC increased with age, duration of use, body mass and progestin potency [ 38 ]. Exogenous hormones are known to influence several physiological mechanisms implicated in blood pressure regulation, including the renin-angiotensin-aldosterone system (RAAS), endothelial function, the sympathetic nervous system, oxidative stress [ 39 ], and arterial stiffness [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Arterial Stiffness and Hemodynamics in Young Women: The Effects of Oral Contraceptive Intake and Physical Habits

Enéa

Laffetas

Pichon

et al. 2021

IJERPH

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Oral contraceptive (OC) intake seems to be associated with increased central hemodynamics and arterial stiffness. Conversely, physical activity (PA) is known to induce benefits on vascular structure and function, suggesting that the negative effects of the OC pill could be counterbalanced by regular PA. The aim of this cross-sectional study was to determine (1) whether OC intake in young women is associated with higher values of hemodynamic parameters and arterial stiffness and (2) whether these negative effects could be counterbalanced by regular physical activity. Forty-nine young healthy women (21.9 years ± 2.1) were recruited and divided into 4 groups, depending on their hormonal status (OC users: OC+ or non-OC users: OC−) and their physical habits (active/inactive). Assessments of central hemodynamics (central blood pressure, Aix75) and pulse wave velocity (PWV) were performed using applanation tonometry. cBP was higher in OC+ vs. OC−, while PWV was similar between these two groups. No interaction between physical activity and hormonal status was observed for any of these variables. Nevertheless, PWV was lower in young active women compared with age-matched inactive women, suggesting that the positive effect of regular physical exercise on the cardiovascular system is already visible in the first years of women’s adulthood, whatever the hormonal status.

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Section: Discussionmentioning

confidence: 99%

Arterial Stiffness and Hemodynamics in Young Women: The Effects of Oral Contraceptive Intake and Physical Habits

Enéa

Laffetas

Pichon

et al. 2021

IJERPH

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show abstract

“…32 Cardiovascular disorders in this study were indicated by a change in blood pressure, and blood pressure variation was obtained for each control, but cases of hypertension that made the participants need to stop taking the medication were not found. 33,34 There was no rejection of Pill A and B from the participants. This study used an open-label method, so the researchers and the subjects knew the investigated drug of this study.…”

Section: Original Articlementioning

confidence: 95%

A study of efficacy, safety, and acceptance of two combined oral contraceptive pills containing 150 mcg Levonorgestrel and 30 mcg Ethinyl Estradiol at Dr. Kariadi Hospital, Semarang, Indonesia

et al. 2022

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Background: Combine Oral Contraceptives (COCs) pills is one of the many popular contraceptives worldwide, with 100 million women who use contraceptive pills. To increase the choice of oral contraceptives, COCs Novadiol® (Pill A) domestic production, which has the same dosage as Microgynon® (Pill B), are still imported drugs. This study aims to determine Pill A's efficacy, safety and acceptance level compared to Pill B for 3 months. Methods: The study was a randomized control clinical trial, an open-label trial in 200 women of childbearing age who met the inclusion and exclusion criteria from July to November 2015. Data were analyzed using SPSS version 20 for Windows. Results: About 300 participants were selected and 200 met the inclusion and exclusion criteria who participated study from the beginning to the end of the study period. In the first month of observation, 1 complaint of dizziness in pill A and 2 from pill B. One nausea complaint was found in the participant from Pill A. These differences were not statistically significant (p>0.05). In the second month of observation, 1 complained of dizziness from pill B and 1 nausea from Pill A. In the third month, observation found no complaints about using Pill A and pill B. There were changes in menstrual patterns in both pills and bleeding outside the cycle during the use of 3 months, but they were not statistically significant (p>0.05). Conclusion: Pills A has the same efficacy, safety and acceptance when compared to the use of birth control pills B for 3 months.

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“…Desde sua criação, foi evidenciada relação com o risco cardiovascular e, mesmo com o avanço na indústria farmacêutica em desenvolver combinações de menor risco e redução da mortalidade nas mulheres em uso dessa medicação, ainda são observados eventos como infarto agudo do miocárdio (IAM), tromboembolismo venoso (TEV) e acidente vascular cerebral (AVC) pelo seu efeito pró-coagulante 6 .…”

Section: Introductionunclassified

Medical students' use of oral contraceptives: a viewpoint focusing on cardiovascular health

Santos

Bandeira

Chagas

et al. 2023

JBG

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Introduction: Women of all age groups use oral contraceptives (OCP) to prevent unintended pregnancy. The relationship between the use of oral contraceptives (OC) and the risk for cardiovascular (CV) events, such as venous thromboembolism (VTE), acute myocardial infarction (AMI), and stroke, has been studied for many years. Some adverse reactions are reported by some women, such as headache and dizziness. Objective: To analyze the prevalence of OC use among medical students, as well as the prevalence of self-reported symptoms common to cardiovascular disease (CVD), lipemia, and the frequency of gynecological and cardiological evaluations. Methods: The present study was constructed from an anonymous CV risk factor (RF) self-report questionnaire answered by female medical students during June and November 2020. Data were tabulated in Excel and statistics performed by the Minitab program. Results: About 75% of the women interviewed take or have taken OACs, and 70% of the total of 217 interviewees have some CV symptoms. Conclusion: Cardiovascular symptoms were reported among the female students who use OC, and the correlation between the time of use and the symptoms was considered statistically significant.

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Oral Contraceptives and Cardiovascular Risk: Adding Clinical Evidence to the Pathophysiology

Cited by 4 publications

References 7 publications

Arterial Stiffness and Hemodynamics in Young Women: The Effects of Oral Contraceptive Intake and Physical Habits

Arterial Stiffness and Hemodynamics in Young Women: The Effects of Oral Contraceptive Intake and Physical Habits

A study of efficacy, safety, and acceptance of two combined oral contraceptive pills containing 150 mcg Levonorgestrel and 30 mcg Ethinyl Estradiol at Dr. Kariadi Hospital, Semarang, Indonesia

Medical students' use of oral contraceptives: a viewpoint focusing on cardiovascular health

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