Oral condition, chemistry of saliva, and salivary levels of Streptococcus mutans in thalassemic patients

Lugliè, Pietrina Francesca; Campus, Guglielmo; Deiola, C.; Mela, Maria; Gallisai, D.

doi:10.1007/s00784-002-0179-y

Cited by 22 publications

(25 citation statements)

References 8 publications

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“…Orofacial changes in TM have described in earlier reports (4)(5)(6)(7)(8). TM patients are at high risk of dental caries (9,10) periodontal diseases (8,11) and oral infection (5,12). They also have smaller tooth crown (13), reduced dental arches dimensions (14), and dental discoloration due to chronic jaundice (15).…”

Section: Introductionmentioning

confidence: 99%

Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major

Hattab¹

2013

J Oral Sci

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Dental development and physical growth are of particular interest in pediatric dentistry and orthodontics. This study evaluated these variables in patients with thalassemia major (TM). Physical growth was assessed in 54 patients (31 males and 23 females) aged 5.5 to 18.3 years and dental development was analyzed using panoramic radiographs from 39 of the 54 patients. The Demirjian system was used to characterize dental development of the seven left mandibular permanent teeth. Chronologic age (CA) and dental age (DA) were compared using the paired t-test, and the correlation between CA and extent of delay in dental development (DA minus CA) was assessed using Pearson's correlation coefficients. Growth retardation (< 10th percentile for height and weight) was present in 75.9% of TM patients. Height less than the third percentile was noted in 41.9% (13/31) of males and 34.8% (8/23) of females. Mean (SD) body mass index was 16.5 ± 2.2 kg/m 2 . The extent of growth retardation increased with advancing age. Patient radiographs revealed a delay in dental development in 31 of 39 (79.5%) of participants (mean delay, 1.12 years in males and 0.81 years in females; range, 0.1 to 2.7 years). The mean difference between CA and DA was 0.97 years (P < 0.001). CA was significant correlated with extent of dental developmental delay (r = 0.64, P < 0.01). The results show that, among children and adolescents with TM, the proportions of those who had short stature, were underweight, and had a low growth rate increased with age. In addition, participants had significant delays in dental development. (J Oral Sci 55, [71][72][73][74][75][76][77] 2013)

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Section: Introductionmentioning

confidence: 99%

Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major

Hattab¹

2013

J Oral Sci

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“…Individuals who have thalassemia have a higher rate of dental decay as compared to people who do not have thalassemia (20). Thalassemia patients’ gums and the lining of their mouth become pale due to anaemia (2), they might also experience a sore or burning tongue due to folate deficiency (10, 22). Thalassaemic patients also experience painful swelling of salivary glands and a dry mouth which leads to reduced salivary protection (22).…”

Section: Introductionmentioning

confidence: 99%

“…Thalassemia patients’ gums and the lining of their mouth become pale due to anaemia (2), they might also experience a sore or burning tongue due to folate deficiency (10, 22). Thalassaemic patients also experience painful swelling of salivary glands and a dry mouth which leads to reduced salivary protection (22). It has been seen from the previous studies that thalassaemic patients are prone to dental decay (20).…”

Section: Introductionmentioning

confidence: 99%

“…It has been seen from the previous studies that thalassaemic patients are prone to dental decay (20). This, at times, happens because the patients do not tend to regular dental care or hesitate to go to a dentist thinking they will not understand their condition; there have also been cases where the thalassaemic patients are more concerned with the serious medical complications of thalassemia and their teeth get neglected in the process (20, 22). Due to a higher rate of tooth decay and thalassaemic patients not paying much attention to their dental care through restorative dental treatments/fillings, there comes a stage when individuals will start experiencing pain in their teeth.…”

Section: Introductionmentioning

confidence: 99%

“…Due to a higher rate of tooth decay and thalassaemic patients not paying much attention to their dental care through restorative dental treatments/fillings, there comes a stage when individuals will start experiencing pain in their teeth. It is then that thalassaemic patients try to get dental services in emergency (22). When patients start experiencing pain, this is when the dental decay has gone to an advanced stage.…”

Section: Introductionmentioning

confidence: 99%

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Thalassemia review: features, dental considerations and management

Helmi¹,

Bashir²,

Shireen³

et al. 2017

Electron physician

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Thalassemia is a genetic disorder that involves abnormal haemoglobin formation. The two main categories of thalassemia are alpha and beta thalassemia that are then divided into further subcategories. While some mild forms of thalassemia might even go unnoticed and only cause mild anaemia and iron deficiency problems in patients, other more severe forms of thalassemia can even result in death. Individuals with thalassemia can get treatment according to the level of severity of their condition. The main oral manifestations of thalassemia are Class II malocclusion, maxillary protrusion, high caries index, severe gingivitis. Any dental surgical procedure for such patients should be done under antibiotic cover and immediately after transfusion. Caution should be exercised in thalassemia patients due to complications related to compromised immunity and cardiovascular issues. Multidisciplinary approach involving dental surgeon, haematologist and orthodontist is the best advised approach.

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Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Boström

Lira-Júnior

2019

Curr Oral Health Rep

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Purpose of Review This review aims to summarize the literature on inherited hemoglobin and coagulation disorders, focusing on sickle cell disease (SCD), thalassemia, hemophilia, and von Willebrand disease (vWD), and their impact on oral health. Clinical dental management of patients with these conditions is also reviewed. Recent Findings There is no evident association between caries and SCD. Despite limited available studies, there may be a possible association between caries and thalassemia, which could relate to salivary changes in immunoglobulin A and Streptococcus mutans reported in these patients. Controversial results on the caries experience of hemophilia and vWD patients are found in the literature, which are likely to reflect differences in the provided preventive dental care of these patients rather than a biological association. Current evidence does not support any association between periodontal disease and SCD. The literature on periodontal disease and thalassemia shows controversial results although some evidence suggests differences in the gingival inflammation of thalassemia patients with increased levels of inflammatory cytokines and matrix metalloproteinases, deserving further investigation. The available literature does not provide evidence of an increased risk for gingival bleeding or periodontal disease in patients with hemophilia or vWD. Dental management of these patients requires appropriate measures to prevent infection and excessive bleeding. The use of local hemostatic may often be sufficient; however, in severe bleeding disorders, systemic hemostatic or replacement therapy may be required, and procedures are recommended to be planned with the patient's hematologist. Summary Maintaining good oral health through preventive dentistry is important for patients with inherited hemoglobin and coagulation disorders as that may prevent the risk of infection and the need for invasive dental treatments that can result in bleeding complications. Keywords Hematologic diseases. Anemia. Blood coagulation disorders. Oral health. Periodontal diseases. Dental caries This article is part of the Topical Collection on Systemic Diseases * Elisabeth A.

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Oral condition, chemistry of saliva, and salivary levels of Streptococcus mutans in thalassemic patients

Cited by 22 publications

References 8 publications

Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major

Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major

Thalassemia review: features, dental considerations and management

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

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