Oral complications following radiation therapy: A five-year retrospective report

Implications of radiation dosimetry of the mandible in patients with carcinomas of the oral cavity and nasopharynx treated with intensity modulated radiation therapy

“…Reports published over the past 14 years demonstrate mean incidence rate of 3.5% (range 0.8%-10.4%) 8,17,23,25,26 . The apparent decline in overall incidence of this complication may reflect broader awareness of the factors that predispose to ORN 26 and the increasing use of prophylactic strategies to manage the post-irradiated dental patient, or it may reflect a change in patterns of practice in favour of primary surgery and adjuvant radiotherapy as opposed to primary radiotherapy.…”

“…There are many factors that predispose to ORN: tumor site, oncologic stage, radiation dose, jaw volume within treatment fields, pre-radiation dental treatment, post-radiation dental treatment, use of dentures, use of brachytherapy, and use of combined chemoradiotherapy 1,[7][8][9]17,22,23 .…”

Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review

“…Extraction after 5 years radiotherapy (ORN) CARL and IKNER 12 5(0) 3(0) 0(0) MAKKONEN 54 4(0) 21(0) SCHWEIGER 73 16 (1) 8(1) BEUMER et al 9 14 (2) 48 (12) 10(2) WILDERMUTH and CANTRIL 87 1(0) 2(0) 2(0) 78 0 0 0% 7 0 0% DAVID et al 22 12 0 0% 12 0 0% TONG et al 81 0 0 0% 43 4 9.30% CARL and IKNER 12 2 0 0% 6 0 0% LAMBERT et al 46 15 most studies in the literature that the mandible has a higher risk of developing ORN compared with the maxilla 11,19,43,60,71,79 . The pattern of blood supply to the mandible has been implicated as a primary reason for this finding 37,79 .…”

“…Most authors suggest extraction should be performed with minimal trauma or atraumatically to reduce the risk of developing ORN 28,42,45,50,59,73,74,78,81 .…”

The effect of prior radiation therapy for treatment of nasopharyngeal cancer on wound healing following extractions: incidence of complications and risk factors

“…Numerous predisposing risk factors, such as location of tumour, history of tumour surgery, total dose of radiation, radiation dose per day, mode of radiation therapy, time period from radiation therapy to extraction, presence of dental trauma, dental status and competency of the clinician performing the extraction, have been proposed to be contributory to ORN development 3,6,13,15,17 . Of these, the dosage of radiation is frequently quoted as a crucial factor.…”