The effect of prior radiation therapy for treatment of nasopharyngeal cancer on wound healing following extractions: incidence of complications and risk factors

Prophylactic use of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy for cancer of the head and neck

“…Although several different regimens have been proposed, 14,[16][17][18][19][20][21] there is no consensus about which is most effective. In our study, 9 different regimens were prescribed for various reasons such as allergies, medical history, and previous drug history.…”

Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review

“…Most authors suggest extraction should be performed with minimal trauma or atraumatically to reduce the risk of developing ORN 28,42,45,50,59,73,74,78,81 .…”

“…Alveoloplasty and suturing of the socket are commonly performed to avoid ORN 9,12,16,28,46,50,58,74,81 . This procedure attempts to trim off sharp bony spicules and provide soft tissue cover for the sockets to prevent bone exposure 3,21,75 .…”

“…Limiting the number of teeth extracted per-session has been suggested to prevent ORN by avoiding overburdening the already limited blood supply 9,14,59 . Other less popular suggestions include avoiding lidocaine or adrenaline-containing local anesthesia 16,50,59 , the use of a nasogastric tube during the postoperative period 39 , elastic or orthodontic extraction 63,72 and chlorhexidine mouthwash 50,81 . These measures have not been supported by evidence as no specific studies have been performed to assess their effectiveness in preventing ORN in post-radiation extraction.…”

Maxillary osteoradionecrosis – review of published literature: incidence, classification, risk factors, physiopathology and prevention

“…The possible explanation is vascular limitations in the mandible and the fact that it is more often inside of the field of irradiation due to head and neck cancer type 13 . Trauma was recognized to be part of physiopathology of ORN in the theory developed by Meyer 15 (1970), however it is not currently considered because many ORN occurs spontaneously, although it corresponds to a very important risk factor to ORN [17][18][19] . Among the several types of trauma that can affect bone, teeth extraction is the most associated to ORN especially in the post-irradiation period 13 .…”