Oral Colonization of Helicobacter pylori: Risk Factors and Response to Eradication Therapy

Gürbüz, Ahmet Kemal; Özel, Ahmet; Yazgan, Yusuf; Çeli̇k, Murat; Yıldırım, Şükrü

doi:10.1097/01.smj.0000051069.50950.2b

Cited by 38 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results were found in accordance with the result of Liu et al [25], Gürbüz et al [35], Butt et al [36], Song et al [81] and Liu et al [6], but found different from the studies of Berroteran et al [37], Al-Refai et al [26] and Nguyen et al [39]. Dental biofilm provides an optimal pH, temperature and microaerophilic environment required for the survival of H.pylori [24].…”

Section: Discussionsupporting

confidence: 93%

“…The diagnostic criteria followed the WHO protocol [34]. Oral examination involved assessment of dentition (number of teeth, carious teeth, plaque index and gingival index), halitosis and hygienic procedures (frequency of daily toothbrushing, sort of used toothbrush, a yearly frequency of changing toothbrush, feeding with premasticated food, common usage of glasses, spoons in a family) [25, 35–42]. …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

et al. 2017

View full text Add to dashboard Cite

BackgroundThe oral cavity can be an extra-gastric reservoir for Helicobacter pylori (H.pylori). This can play a role in the pathogenesis of halitosis, glossitis, recurrent aphthous stomatitis, and dental caries. The present study was conducted to detect the presence of H.pylori within the dental biofilm and in saliva samples collected from children suffering from dyspepsia and children without any gastrointestinal complaints. Associations with gastric infection, halitosis, and some oral parameters were also evaluated.MethodsSeventy children (aged between 5–16) with dyspepsia were selected for the study group and control group composed of 30 healthy children without dyspepsia were also included in the study. After detailed oral and clinical examinations for oral parameters, saliva, and supragingival dental biofilm samples were collected for 16S rRNA and 23S rRNA genes detection by real-time polymerase chain reaction (RT-PCR). The presence of gastric H.pylori was evaluated in endoscopic biopsy specimens histopathologically. Halitosis was evaluated by benzoyl-DL-arginine-naphthylamid (BANA) test. Salivary S.mutans and Lactobacilli sp. counts were also carried out by commercial kits.Results H.pylori was histopathologically detected amongst 83% of the children with the dyspeptic condition. The detection rate of this bacteria in dental biofilm and saliva samples and halitosis were found relatively higher in the dyspeptic children rather than the control group (p < 0.01). Halitosis was not significantly different between dyspeptic children and those detected with H.pylori (p > 0.05). In the gastric H.pylori positive group with dyspepsia, DMFT/S and dmft/s numbers and plaque indices were found higher than the control group (p < 0.01). Only plaque indices of gastric H.pylori negative group with dyspepsia were found higher than the control group (p < 0.01). S.mutans and Lactobacilli sp. counts were not significantly different between gastric H.pylori positive and negative groups (p > 0.05). Comparing to those with negative for both genes, in children whose dental biofilm and saliva samples were positive for both 16S rRNA and 23S rRNA genes, significantly higher results for halitosis, and DMFS numbers and significantly lower results for dmfs numbers and pH values were found (p < 0.01).Conclusions Helicobacter pylori can occur in the oral cavity aside and independently from the stomach. However, the high number of bacteria in the oral cavities of children with gastric H.pylori, an association between the presence of H.pylori and halitosis, DMFS, and pH were found.Electronic supplementary materialThe online version of this article (doi:10.1186/s12903-017-0361-x) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Studies utilizing urease tests to detect the presence of the microorganism in the dental plaque have reported very high prevalence rates. Except for one study which reported a 25.2% prevalence of coinfection, all the other studies utilizing urease tests have reported a coinfection rate in excess of 32%, with one study reporting a prevalence rate of 81.3% [30]. In studies involving PCR, the prevalence rates have ranged between 0% and 47.6% with only 5 out of the 11 studies reporting a prevalence rate above 30%.…”

Section: Methodsmentioning

confidence: 99%

“…A total of 8 studies [30, 40–46] were reviewed in which the effect of anti- H. pylori therapy on its presence in the dental plaque was evaluated. The summary of these studies are given in Table 7.…”

Section: Methodsmentioning

confidence: 99%

“…The summary of these studies are given in Table 7. In 6 of these 8 studies, PCR was used to detect H. pylori in dental plaque while in one study [30] urease test was used and in the other [46] smear cytology was used. In their study on 82 H. pylori positive patients, Butt et al [46] treated 27 of these patients with anti- H. pylori therapy (triple therapy-2 antibiotics and 1 proton pump inhibitor) alone and reported 100% prevalence of H. pylori in the dental plaque of these 27 patients after 10 days of treatment.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Oral Cavity as an Extragastric Reservoir of Helicobacter pylori

Sayed

Anand

Kamath

et al. 2014

ISRN Gastroenterology

View full text Add to dashboard Cite

Background. Several studies were reported on the prevalence, and relationship between the existence of Helicobacter pylori (H. pylori) in oral cavity and in stomach of patients. The purpose of this study was to systematically review the existing literature on the presence of H. pylori in the oral cavity and its link to gastric infection, the existence of coinfection, and the impact of anti-H. pylori therapy on the dental plaque and vice versa. Method. Two authors independently searched the Medline, EMBASE, Cochrane Library, Web of Science, Google Scholar, and Scopus databases for relevant studies. The articles were analyzed critically and all qualified studies were included. The search was carried out by using a combined text and the MeSH search strategies: using the key words Helicobacter, Helicobacter pylori, and H. pylori in combination with dental plaque, periodontitis, and oral hygiene. Results. The data was presented in 8 tables and each topic separately discussed. Conclusion. Based on the systematic review of the available literature on H. pylori infection and its presence in the oral cavity, it can be concluded that dental plaque can act as a reservoir, and proper oral hygiene maintenance is essential to prevent reinfection. Due to the diversified methods and population groups involved in the available literature, no concrete evidence can be laid down. Further studies are necessary to establish the role of H. pylori in the oral cavity and its eradication on preventing the gastroduodenal infection.

show abstract

Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan

Take

Mizuno²,

Ishiki

et al. 2012

J Gastroenterol

View full text Add to dashboard Cite

show abstract

Oral Colonization of Helicobacter pylori: Risk Factors and Response to Eradication Therapy

Abstract: Using CLOtest to detect H. pylori in dental plaque is a reliable first-line diagnostic approach for gastric H. pylori infection. Dental plaque might be a sanctuary for H. pylori, leading to gastric recurrence.

Cited by 38 publications

References 20 publications

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

Oral Cavity as an Extragastric Reservoir of Helicobacter pylori

Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan

Contact Info

Product

Resources

About