Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption

Andrès, Emmanuel; Kurtz, Jean‐Emmanuel; Perrin, A; Maloisel, Frédéric; Demangeat, C; Goichot, B.; Schlienger, Jean-Louis

doi:10.1016/s0002-9343(01)00792-6

Cited by 82 publications

(65 citation statements)

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“…However, this dosage regimen has been continuously and markedly decreased in these last years (see or current recommendations in [29], perhaps because absorption by the intrinsic factor-cubilin complex is maintained (for free not-bound cobalamin), and adds to the cobalamin portion that is absorbed by passive diffusion. In one of the studies conducted by the Strasbourg team, patients having received 250 to 500µg/day exhibited favourable biological and clinical responses that were similar in size to those observed with the full dose [31]. A similar observation was later made in several other clinical trials using still lower dose levels [34,36,39].…”

Section: Treatmentmentioning

confidence: 53%

“…We have recently published an exhaustive review of the efficacy of oral cobalamin therapy in reference [29]. Table 3 summarizes the results of various not blinded, placebo-controlled trials that we conducted with oral cyanocobalamin in the context of FCM management [30][31][32]. All of the patients who were treated orally corrected their vitamin B12 levels and at least 80% corrected their hematological abnormalities.…”

Section: Treatmentmentioning

confidence: 99%

“…All of the patients who were treated orally corrected their vitamin B12 levels and at least 80% corrected their hematological abnormalities. Moreover, half of the patients experienced a clinical improvement on oral treatment [29][30][31][32]34]. It is to note that the effect of oral cobalamin treatment in patients presenting with severe neurological manifestations has not yet been adequately documented [29].…”

Section: Treatmentmentioning

confidence: 99%

“…Oral cyanocobalamin: 650 µg/day during 3 months -Normalisation of serum cobalamin levels in 80% of subjects -Significant 1.9g/dl increase in Hb and significant 7.8fl de crease in ECV -Improvement of clinical abnormalities in 20% of subjects [31] -Open prospective study -n = 30 -Cobalamin deficiency related to food-cobalamin malabsorption…”

Section: Main Clinical Manifestationsmentioning

confidence: 99%

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The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Serraj¹

2011

J Blood Disord Transfus

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SummaryThis article presents recent findings on cobalamin deficiencies due to food-cobalamin malabsorption or nondissociation of vitamin B12 from its carrier proteins syndrome. These findings might be of interest to medical practitioners. This disorder, for which a definitive consensus on the criteria for diagnosis is not yet available, is the leading cause of cobalamin deficiency in the elderly. In practice, food-cobalamin malabsorption is a diagnosis of exclusion, and requires the deductive elimination of all other causes of cobalamin deficiencies, particularly pernicious anaemia. The causes or associated disorders of food-cobalamin malabsorption are multiple and include gastric pathologies, Helicobacter pylori infections and certain drugs (biguanides and proton pump inhibitors). Depending on the disease aetiology, treatment of food-cobalamin malabsorption involves oral supplementation of doses lower than those required for pernicious anaemia.

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Section: Treatmentmentioning

confidence: 53%

Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Main Clinical Manifestationsmentioning

confidence: 99%

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The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Serraj¹

2011

J Blood Disord Transfus

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“…Le traitement par voie orale permet une amélioration significative du taux sérique de la vitamine B12 et des paramètres hématologiques (taux d'hémoglobine, volume globulaire moyen), aussi bien chez les patients atteints de syndrome de non-dissociation de la vitamine B12 de ses protéines porteuses que chez ceux atteints d'une anémie de Biermer [5,7,15]. Dans une étude portant sur 120 patients, Eussen et al ont cherché à déterminer la dose de vitamine B12 nécessaire per os pour réduire de 80 à 90 % la concentration plasmatique de l'acide méthylmalo-nique.…”

Section: Diagnostic Et Traitement De La Carence En Vitamine B12unclassified

Carence en vitamine B12 (1^repartie) : mise au point

Loup-Leuciuc

Loup

Lombardi

et al. 2011

Med Buccale Chir Buccale

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(Reçu le 12 mai 2011, accepté le 24 juin 2011) Mots clés : vitamine B12 / métabolisme / carence / manifestationsRésumé -Classiquement, la carence en vitamine B12 s'accompagne d'une anémie mégaloblastique, de manifestations neuropsychiatriques et d'une glossite de Hunter. En réalité, les manifestations sont protéiformes et chacune d'elles peut rester longtemps isolée. Les manifestations stomatologiques, souvent discrètes, peuvent précéder de plusieurs années les autres manifestations. Elles constituent parfois un signe d'appel pour le dépistage précoce de cette carence. Depuis une bonne dizaine d'années, la conception de la physiopathologie de la carence en vitamine B12 a beaucoup évolué : on a identifié le syndrome de non-dissociation de la vitamine B12 des protéines porteuses qui constitue maintenant la principale cause de carence en vitamine B12 et il a été démontré qu'on peut effectuer un traitement de la carence per os. Key words: vitamin B12 / metabolism / deficiency / manifestationsAbstract -Vitamin B12 deficency. Part 1: update and littérature review. Vitamin B12 deficiency is classically accompanied by a megaloblastic anemia, neuropsychiatric disorders and an Hunter glossitis. Clinical manifestations are indeed polymorphic and each may remain the only one for a long period of time. Stomatological manifestations, often mild, may precede the others of many years. They sometimes are the first sign to early diagnose this deficiency. Since the last ten years, the physiopathology of vitamin B12 deficiency has considerably changed. In fact, nowadays, the main cause is the syndrome of food cobalamin malabsorption. It has also been demonstrated that the deficiency may now treated by an oral cobalamin therapy.La vitamine B12 est une vitamine hydrosoluble qui a une structure chimique proche de celle de l'hème avec un atome central constitué par du cobalt, d'où le nom de cobalamine (Fig. 1).Elle existe sous plusieurs formes regroupées dans la famille des cobalamines : cyanocobalamine, hydroxocobalamine, mé-thylcobalamine et adénosylcobalamine. La cyanocobalamine et l'hydroxocobalamine sont les seules formes stables. On peut considérer que les recherches sur la vitamine B12 ont commencé au XIX e siècle avec la description d'une anémie mortelle, l'anémie pernicieuse, par Thomas Addison et Michael Anton Biermer. Vers 1920, George Whipple, George Minot et William Murphy, tous les trois Prix Nobel de médecine en 1934, ont démontré que des extraits de foie sous forme de compléments alimentaires étaient susceptibles de corriger certaines anémies. On en a conclu que les extraits de foie contenaient le facteur extrinsèque, en réalité de la vitamine

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Metformin-Associated Vitamin B12 Deficiency

Andrès¹,

Noel²,

Goichot³

2002

Archives of Internal Medicine

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Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption

Cited by 82 publications

References 15 publications

The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Carence en vitamine B12 (1^repartie) : mise au point

Metformin-Associated Vitamin B12 Deficiency

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Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption

Cited by 82 publications

References 15 publications

The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Carence en vitamine B12 (1repartie) : mise au point

Metformin-Associated Vitamin B12 Deficiency

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Product

Resources

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Carence en vitamine B12 (1^repartie) : mise au point