Oral chronic <scp>GVHD</scp> outcomes and resource utilization: a subanalysis from the chronic <scp>GVHD</scp> consortium

Yuan, Anna; Chai, Xiaoyu; Martins, Fabiana; Arai, Sally; Arora, Mukta; Corrêa, Maria Elvira Pizzigatti; Pidala, Joseph; Cutler, Corey; Lee, Stephanie J.; Treister, Nathaniel S.

doi:10.1111/odi.12429

Cited by 6 publications

(2 citation statements)

References 30 publications

(29 reference statements)

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“…This practice is consistent with treatment approaches in other organs [69]. Data from cGVHD Consortium sites has confirmed that treatment behavior follows these recommendations with topical therapies more likely to be used in patients reporting pain and decreased oral function [70]. Follow-up is recommended to confirm symptom control and restoration of mucosal integrity.…”

Section: Oral Mucosal Cgvhdsupporting

confidence: 54%

Oral Chronic Graft-Versus-Host Disease

Dean

Sroussi

2022

Front. Oral. Health

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Chronic oral graft-versus-host disease (cGVHD) is a complex, frequent, and highly impactful complication of allogeneic hematopoietic cell transplantation (alloHCT). It represents the leading cause of morbidity and mortality in long-term alloHCT survivors. cGVHD can affect almost any visceral organ system and commonly affects the skin, eyes and mouth, manifesting with signs and symptoms similar to other known immune-mediated and autoimmune diseases. Oral manifestations of GVHD include inflammation, thinning, and ulceration of oral mucosal tissues (similar to lichen planus), lymphocyte-mediated salivary gland dysfunction (similar to Sjögren/Sicca Syndrome), and decreased oral opening (trismus) secondary to sclerosis of oral and perioral tissues (analogous to limitation in scleroderma). Potential sequelae include severe mucosal pain, compromised nutrition, weight loss, limitation in opening, and sometimes irreversible fibrosis of the salivary glands. While some cases can be managed with topical therapies, management may also require long-term targeted immunosuppressive and/or corticosteroid therapy with associated risk of local and systemic infection, hyperglycemia, kidney dysfunction, osteopenia/osteoporosis, and possibly secondary malignancies. The aim of this mini-review is to provide an up-to-date review of literature related to the diagnosis and management of oral cGVHD to aid dental and medical clinicians in optimizing oral cGVHD therapy while minimizing potential adverse effects.

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Section: Oral Mucosal Cgvhdsupporting

confidence: 54%

Oral Chronic Graft-Versus-Host Disease

Dean

Sroussi

2022

Front. Oral. Health

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“…In the KSA, Aboalela et al reported oral GvHD in 30.6% of patients, identifying weight loss was more prevalent among oral GvHD, and oral mucositis was linked to significant weight loss [ 45 ]. Patients with OLL associated with GvHD undergo similar treatment as for OLP, but often require closer monitoring due to both the potentially malignant nature of OLL in combination with the risk of secondary malignancies arising as a complication of GvHD [ 46 ].…”

Section: Graft-versus-host Diseasementioning

confidence: 99%

Oral Potentially Malignant Disorders and Oral Cancer in Saudi Arabia: An Epidemiological Review of the Literature

Aljohani,

Alqarni,

Harte

et al. 2024

JCM

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Background: Oral potentially malignant disorders (OPMDs) are a group of chronic oral mucosal diseases associated with an increased risk of malignant transformation. Multiple studies have investigated the prevalence of these conditions in multiple regions; however, there are limited data about the prevalence of OPMDs in the Kingdom of Saudi Arabia (KSA). This paper aims to review the prevalence of OPMDs in the KSA, to ensure better understanding of the population risk and propose a more standardised approach to the diagnosis and management of this group across the KSA. In addition, this review will discuss the prevalence of oral cancer in the KSA, considering independent risk factors for oral cancer development. Methods: Electronic databases including PubMed, Medline, Medscape, ScienceDirect, StatPearls, BMC Oral Health and the Cochrane Library were searched with the keywords “Oral Potentially Malignant Disorders”; “Saudi Arabia”; and “Oral Cancer”. Identified articles were reviewed independently by 2 reviewers against defined inclusion and exclusion criteria. Results: 16 studies were included in this review. The prevalence of OPMDs in KSA varies significantly depending on age, gender, social habits, background disease and dental status. Conclusions: This review highlights the need for up-to-date data on the prevalence, distribution, and characteristics of OPMDs in KSA. The diverse prevalence rates and distinct characteristics of various OPMDs emphasise the necessity for targeted preventive measures. As the data on OPMDs in KSA remains limited, future research efforts should prioritise the establishment of comprehensive epidemiological studies to inform effective public health interventions in this region.

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