Dermatologic Diseases

Neville, Brad W.; Damm, Douglas D; Allen, Carl M.; Angela, C.

doi:10.1016/b978-0-323-55225-7.00016-6

Cited by 8 publications

(27 citation statements)

References 122 publications

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“…Indirect immunofluorescent studies have demonstrated that sufferers from chronic ulcerative stomatitis have circulating IgG, and sometimes IgA autoantibodies, specifically targeting the nuclear protein ∆Np63α of keratinocytes in the basal and parabasal layers of stratified squamous epithelium . Circulating immunoglobulins that target epithelial antigens are not uncommon, particularly following active inflammatory processes.…”

Section: Histopathological and Immunofluorescent Featuresmentioning

confidence: 99%

“…In about five percent of affected persons, the skin is involved, and there have been reports of concurrent lesions on the genital mucosa and conjunctiva. The etiopathogenesis of the condition is not well defined, but it has been shown that an autoantibody reaction, presumably against a 70 kDa epithelial nuclear protein, ∆Np63α, an isoform of p63 protein, plays an essential role . Glucocorticosteroids, because of their anti‐inflammatory and immunosuppressive properties are the main agents for the treatment of other erosive/ulcerative immunopathogenic mucocutaneous diseases (i.e., pemphigus vulgaris, lichen planus, pemphigoid group of diseases) , however these agents have not been found to be effective in the treatment of chronic ulcerative stomatitis ().…”

Section: Introductionmentioning

confidence: 99%

“…Direct immunofluorescent studies of perilesional tissue have shown a speckled or granular pattern of IgG deposition with a perinuclear distribution within keratinocytes of the basal and parabasal layers of the stratified squamous cell epithelium . Indirect immunofluorescent studies have demonstrated that circulating IgG antibodies target the nuclear protein deltaNp63alpha (ΔNp63α) which plays an important role in the differentiation, proliferation, apoptosis and survival of basal keratinocytes, and in epithelial basement membrane adhesion, thus maintaining the integrity of stratified squamous epithelium .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?

Feller

Khammissa

Lemmer

2017

J Oral Pathology Medicine

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Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunofluorescent microscopy are essential for definitive diagnosis. The defining immunopathogenic mechanism is the binding of IgG to the nuclear protein deltaNp63alpha of keratinocytes in the basal and parabasal cell layers of the oral stratified epithelium. DeltaNp63alpha functions as a regulator of epithelial stem cell activity and as an antiapoptotic agent and regulates the expression of cell-to-cell and cell-to-basement membrane adhesion molecules. The autoimmune IgG-deltaNp63alpha interaction is thought to result in damage to the structural attachment of keratinocytes to one another and to the epithelial basement membrane zone and in dysregulation of the cell cycle and apoptosis of basal keratinocytes with the development of erosions or ulcers. The aims of treatment are to suppress the pathogenic immunoinflammatory responses, to prevent local infection and to promote healing. The purpose of this article is to provide a succinct review of the diagnostic, clinical and etiopathogenic features of, and treatment guidelines for chronic ulcerative stomatitis, and to argue that this disease should be regarded as a variant of oral lichen planus, rather than as a distinct entity.

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Section: Histopathological and Immunofluorescent Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is chronic ulcerative stomatitis a variant of lichen planus, or a distinct disease?

Feller

Khammissa

Lemmer

2017

J Oral Pathology Medicine

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“…This gene mapping to X q 12- q 13.1, encoded a ligand Ectodysplasin - A1. Female patients may show partial expression of this abnormal gene [ 2 ]. Hidrotic ED usually presents as an autosomal dominant pattern by changes in the GJB 6 gene, encoding connexin -30 and located in chromosome 13.…”

Section: Discussionmentioning

confidence: 99%

Ectodermal Dysplasia Presenting as Heat Exhaustion in an Adolescent Boy

Guntreddi¹,

Nair²,

Nirujogi

2021

Cureus

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Ectodermal dysplasia (ED) is a rare heterogenous group of ectodermal disorder, which primarily affects skin, hair, nails, eccrine glands, and teeth. Hypohidrotic ED is characterized by hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital decrease in the number of teeth /anodontia - complete absence of teeth). Primary care physicians and dentists play a crucial role in the early diagnosis and subsequent follow ups. A careful and thorough examination of these patients will lead to accurate diagnosis. Timely involvement of a multidisciplinary team in their care including the child psychologist, dermatologist, otorhinolaryngologist, and speech therapist would avoid fatal complications and improve the overall quality of life. In this article, we report that ED is a chronic underdiagnosed condition and can have devastating long-term complications. This is significant because with early diagnosis and prompt education of parents, patients can have better outcome in the prevention and timely management of complications such as heat exhaustion, electrolyte imbalance, heat stroke, and severe dehydration. Our case report would help clinicians familiarize with this rare condition to improve clinical acumen and better the patient outcome.

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“…Approximately 85–90% of all ACCs occur in the parotid gland. 1 Here, we presented an exophytic polypoid tumor at the edentulous alveolar ridge of the left maxillary molar region of a 62-year-old female patient.…”

mentioning

confidence: 93%