NOR-1 immunostain is a good method to confirm the diagnosis of an oral acinic cell carcinoma

Jin, Ying‐Tai; Chang, Julia Yu-Fong; Sun, Andy; Chiang, Chun‐Pin

doi:10.1016/j.jds.2020.11.012

Cited by 3 publications

(1 citation statement)

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“…Of particular note, in some recently published studies, nuclear expression of NOR1 is considered a sensitive and specific diagnostic marker for acinic cell carcinomas (ACCs), a low-grade malignant salivary gland tumor with cells showing serous acinar differentiation, because 1) NOR1 immunostaining was found in all ACC patients, whereas no similar immunostaining was found in non-ACC individuals ( Jin et al, 2021 ; Owosho et al, 2021 ); and 2) NOR1 can distinguish from its mimics on fine-needle aspiration biopsy specimens ( Nguyen et al, 2020 ). However, whether this positive expression of NOR1 is beneficial or detrimental to the progression of ACCs or the treatment and prognosis of ACC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive insights into the function and molecular and pharmacological regulation of neuron-derived orphan receptor 1, an orphan receptor

Hong

Su²,

Huang³

et al. 2022

Front. Pharmacol.

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Neuron-derived orphan receptor 1 (NOR1), also called nuclear receptor subfamily 4 group A member 3 (NR4A3), is a nuclear receptor belonging to the NR4A family. Since no endogenous ligand has been identified to date, NOR1 is also referred to as an orphan receptor. NOR1 is expressed in a variety of cells and tissues, including neurons, vascular smooth muscle cells, T lymphocytes, dendritic cells, tumor cells, heart, liver, and pancreas. Because NOR1 was first identified in apoptotic neurons, it is functionally associated with the regulation of cell migration and the growth of neuronal synapses. In-depth studies have shown that NOR1 can be edited by the immediate early gene and functions as a transcription factor. NOR1 has been shown to be rapidly induced by a number of stimulants including growth factors, fatty acids, and neurotransmitters. Elevated NOR1 levels may be involved in a number of pathophysiological processes. These include regulation of cellular apoptosis and regeneration, neuron formation, contextual fearing memory, inflammation, vascular smooth muscle proliferation, insulin secretion, and tumor development, whereby NOR1 mediates the pathogenesis of numerous diseases such as cerebral ischemia, depression, post-traumatic stress disorder, atherosclerosis, abdominal aortic aneurysm, cardiac hypertrophy, diabetes, osteoarthritis, rheumatoid arthritis, and cancer. However, to date, comprehensive insights into the function of NOR1 are not available in sources published online. In this review, we provide a brief overview of the function and molecular and pharmacological regulation of NOR1 in various pathological or physiological conditions to advance the development of NOR1 as a novel target for disease treatment.

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Section: Introductionmentioning

confidence: 99%