Oral Cavity

SQUAMOUS CELL CARCINOMA OF THE LIP: A RETROSPECTIVE REVIEW OF THE PETER M ACCALLUM CANCER INSTITUTE EXPERIENCE 1979–88

“…[8][9][10]12,14 Substratification of T1 lesions has also been shown to be of prognostic value, 9 however we did not find this in our study. Tumour grade has been reported as significant in predicting recurrence, 6,7,13,14,18,19 and our study concurs with this finding as there was a significant increase in the rate of lesion recurrence with decreasing degree of tumour differentiation (P = 0.0005), predominantly due to an increase in the rate of nodal recurrences. There was a low incidence of nodal metastases at presentation (2% clinically positive lymphadenopathy) compared to an incidence of 10-15% reported elsewhere.…”

“…There was a low incidence of nodal metastases at presentation (2% clinically positive lymphadenopathy) compared to an incidence of 10-15% reported elsewhere. 5,6,9,11,13,14,15,20 The accuracy of clinical assessment of nodal disease was 50%, as found in other studies. 6,20,21 Local recurrence rates of 2.5-15% for T1 lesions have been found in other studies, with recurrence rates for larger lesions (T3 and/or T4) up to 50%.…”

“…Squamous cell carcinoma of the lower lip is a disease that can be successfully treated by surgery or radiotherapy. [5][6][7][8][9][10][11][12][13] Successful treatment has also been described in this review; the incidence of tumour-related mortality was 2.0% over the study period, and the incidence of loco-regional recurrence only 7.5% at 10 years. The profile of the study group, with respect to patient and lesion characteristics, was similar to those in previously published reviews from other centres.…”

“…The profile of the study group, with respect to patient and lesion characteristics, was similar to those in previously published reviews from other centres. 5,6,[8][9][10][12][13][14][15] The preponderance of males and the elderly is typical. 5,16,17 This review identifies the younger age group as having a poorer outcome, a phenomenon that has not been widely reported elsewhere.…”

“…7,12,15,18 In this retrospective review, no significant differences were found between surgery and radiotherapy for local tumour control, or cause-specific survival, for the group overall, nor for the group with T1 lesions. Radiotherapy and surgery have been mainly reported to be equivalent treatments, 5,6,9,13,21 except in studies such as those from Grover et al and Shiptzer et al,12,17 whose respective reports favour surgery as the more beneficial treatment. Any difference in the nodal recurrence rate, between the surgical and radiotherapy patients in our study, is presumably due to the selection of radiotherapy treatment for patients who were older and/or had more advanced disease, rather than due to the treatment modality itself.…”