Oral cancer: The first symptoms and reasons for delaying correct diagnosis and appropriate treatment

Rutkowska, Monika; Hnitecka, Sylwia; Nahajowski, Marek; Dominiak, Marzena; Gerber, Hanna

doi:10.17219/acem/116753

Cited by 29 publications

(50 citation statements)

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“…The causes of delay related to professionals were reported in only five studies, four of them conducted in developing countries ( 17 - 20 ) and one in developed country ( 21 ). The studies indicated that these causes were related to the difficulty of recognizing the initial lesions and early treatment, leading to incorrect diagnoses, which suggests unawareness of oral cancer among health professionals.…”

Section: Resultsmentioning

confidence: 99%

“…[2003] ( 21 ), performed in Japan, in which small tumors and ulcerative lesions were diagnosed as benign lesions, signaling professionals' deficiency of knowledge about oral cancer in both developed and developing countries. Finally, these factors were associated with the delay in the patient’s referral by the doctor or dentist and the performance of the biopsy ( 6 , 17 - 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…The early diagnosis of oral cancer contributes to the implementation of appropriate treatment in early stages of disease evolution, with less invasive surgeries, faster convalescence and better patient survival ( 20 ). On the other hand, the delayed diagnosis increases the care costs of treatment with outpatient or prolonged hospital stay, with main consequences for the most economically disadvantaged ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

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Delay in diagnosis of oral cancer: a systematic review

Lima

Meira²,

Soares³

et al. 2021

Med Oral

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Background Oral cancer represents a worldwide public health problem, being among the most prevalent, associated with high morbidity and mortality rates. This systematic review aimed to review the causes of the delayed diagnosis of oral cancer mainly in the elderly, in developed and developing countries. Material and Methods Search strategy was developed for MEDLINE databases (via PubMed), EMBASE, Web of Science, SCOPUS, and LILACS and for grey literature (Google Scholar, ProQuest and OpenGrey), without language or period restrictions. The risk of bias was assessed using instruments from the Joanna Briggs Institute and the quality of evidence according to the GRADE system. Results The search resulted in 14,473 records, of which only 13 met the eligibility criteria. The total sample was 1,705 participants, with a predominance of males. All studies included reported causes of delayed diagnosis of oral cancer related to the patient and five also reported causes related to health professionals. The scarce knowledge of the population was pointed out as the main cause of delayed diagnosis of this cancer. Regarding the risk of bias, ten studies were classified as low risk and three, as moderate risk. The quality of the evidence was very low for the outcome related to delayed diagnosis of oral cancer. Conclusions Wide dissemination of information on oral cancer is needed, especially for the elderly, such as its initial signs and symptoms, in developed and developing countries. Further studies should be conducted to better understand the causes of delayed diagnosis of oral cancer in countries with different socioeconomic statuses. Key words: Delayed diagnosis, mouth neoplasms, oral neoplasm, aged.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Delay in diagnosis of oral cancer: a systematic review

Lima

Meira²,

Soares³

et al. 2021

Med Oral

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“…The most common symptoms of oral cancer patients may include ulceration (57.7%), induration (44.3%), and rupture (14.1%) [30]. However, due to the asymptomatic and unspecific signs, more than half of the patients went to a doctor in advanced stages when the discomforts worsen or appearance of new symptoms.…”

Section: Clinical Presentationsmentioning

confidence: 99%

Oral Cancer

Xiao¹,

Wang²

2021

Pharynx - Diagnosis and Treatment

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Oral cancer is a frequent head and neck cancer in developing countries and some developed world. According to the World Health Organization classification 2017, oral cancer influences the anatomical subsites including buccal mucosa, the anterior two-third of the tongue, lip, palate, vestibule, alveolus, floor of the mouth, and gingivae. A variety of premalignant lesions are related with the development of oral cancer, such as leukoplakia, erythroplakia, et al. The predominant histological type of oral cancer is squamous cell carcinoma (SCC). Tobacco and alcohol consumption are regarded as critical etiological factors. Due to the unspecific symptoms in early stage, the majority are diagnosed in advanced stages. Despite the development of medicine over decades, the mortality rate of oral cancer remains high, indicating the importance of optimized treatment and screening strategies.

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“…Conversely, and despite the fact that the patient interval may represent the main part of the total time interval to diagnosis and treatment, available information about the relative length of this interval, as well as about the primary care interval and the prereferral interval (from symptom onset to specialist referral), is very limited [15,[21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Impact of the Presenting Symptom on Time Intervals and Diagnostic Routes of Patients with Symptomatic Oral Cancer

Varela‐Centelles

López

López-Cedrún

et al. 2021

Cancers

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This investigation was aimed at determining the time intervals from the presenting symptoms until the beginning of oral cancer treatment and their relative contribution to the total time, and to assess the impact of the presenting symptom on diagnostic timelines and patient referral routes. A cross-sectional, ambispective study was designed to investigate symptomatic incident cases. The Aarhus statement was used as a conceptual framework. Strategies for minimizing potential recall biases were implemented. A sample of 181 patients was recruited (power: 99.5%; α = 0.05). The patient interval reached 58.2 days (95% CI, 40.3–76.2), which accounted for 74% of the whole prereferral interval and for more than one third of the total time interval. The presenting symptom (trigger for consultation) influenced both the number of primary care consultations and the length of time to diagnosis. General dental practitioners generated longer intervals to diagnosis (p < 0.005) and needed more consultations before referring a patient (RR = 0.76; 95% CI, 0.61–0.93), than general medical practitioners. The current study identifies the patient as the main target for interventions to improve awareness and reinforces the need for increased alertness amongst healthcare professionals about presenting symptoms of oral cancer and to diminish the number of prereferral consultations in order to optimize the primary care interval.

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Oral cancer: The first symptoms and reasons for delaying correct diagnosis and appropriate treatment

Cited by 29 publications

References 0 publications

Delay in diagnosis of oral cancer: a systematic review

Delay in diagnosis of oral cancer: a systematic review

Oral Cancer

Impact of the Presenting Symptom on Time Intervals and Diagnostic Routes of Patients with Symptomatic Oral Cancer

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