Oral cancer prevention and control – The approach of the World Health Organization

Petersen, Poul Erik

doi:10.1016/j.oraloncology.2008.05.023

Cited by 520 publications

(431 citation statements)

References 5 publications

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“…The incidence rate for oral cancer in males ranges from 1 -10 cases per 100,000 populations in many countries (Petersen, 2008). Generally, the highest oral cavity cancer rates are found in Melanesia, South-Central Asia, and Central and Eastern Europe and the lowest in Africa, Central America, and Eastern Asia for both males and females.…”

Section: Epidemiology Of Oral Cancermentioning

confidence: 99%

“…These groups often have less access to the health services and health education that would empower them to make decisions to protect and improve their own health. The mortality rate is relatively low for developed countries where health services are available to populations, however, relatively high for low-and middle-income countries with limited access to health facilities, about 70% of all cancer deaths occur in low-and middle-income countries (Petersen, 2008).…”

Section: 5 Socioeconomic Statusmentioning

confidence: 99%

“…The sites of involvement of oral cancer are easily visible and accessible to a dental professional during a routine dental examination without requiring specialized equipment and techniques (Petersen, 2008;WHO, 2005). More than 95% of UK dentists used a visual examination for oral cancer screening because this technique is inexpensive, simple, and acceptable and has high sensitivity and specificity .…”

Section: Screening For Oral Cancer Through Visual Examinationmentioning

confidence: 99%

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Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan

Ahmed

Naidoo

2017

J Canc Educ

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The incidence of oral cancer is rising in the Sudan. Detecting oral cancer at an early stage is the most effective means of improving survival and reducing morbidity from disease. Aim:The aim of the present study was to determine the knowledge, attitude and practice of dentists related to oral cancer prevention and early detection in public dental clinics in Khartoum State, Sudan. Materials and Methods:A cross-sectional survey using an administered structured questionnaire was carried out. The questionnaire consisted of 28 questions that included the key areas of oral cancer prevention and early detection. A sample of 130 dental practitioners was requested to participate in the study. Results:The response rate was 86.92%. The majority were female (68.1%) between the ages of 20 -40 years old. The majority were aware of the major risk factors and the most common presentations of oral cancer. About two thirds (63.7%) perceived that their knowledge on oral cancer was current. However, almost a third (35.4.6%) reported that they had sufficient knowledge concerning oral cancer prevention. More than half (54 percent) reported that they do not carry out any special examination to detect oral cancer in asymptomatic patients. Two thirds (66.3%) believed that their undergraduate training in the diagnosis of oral cancer was inadequate. The vast majority (95.6%) were interested in further oral cancer continuing education and 88.5% that development of referral guidelines can improve the quality of referrals to specialists. Conclusions:The findings of the present study indicate that there is a need for further training in the early detection and prevention of oral cancer, as well as an increased emphasis on oral cancer diagnosis and prevention in the dental training curriculum.3 Declaration I, the undersigned, hereby declare that the work contained in this dissertation is my original work and that it has not been previously in its entirety or in part submitted at any university for a degree.………………………………… …………………………

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Section: Epidemiology Of Oral Cancermentioning

confidence: 99%

Section: 5 Socioeconomic Statusmentioning

confidence: 99%

Section: Screening For Oral Cancer Through Visual Examinationmentioning

confidence: 99%

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Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan

Ahmed

Naidoo

2017

J Canc Educ

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“…Alcohol and smoking alone are responsible for 80% of the cases in males, 61% in females and 74% overall (Warnakulasuriya et al, 2005;Gillison, 2007;Petersen, 2009). Lack of awareness of the risk factors among the community (Pakfetrat et al, 2010;Peker and Alkurt, 2010), un-presented early lesions or delayed diagnosis of cancer makes the job even more challenging for the health care provider (Warnakalasuriya et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of an Intervention Program on Knowledge of Oral Cancer among the Youth of Jazan, Saudi Arabia

Quadri

Saleh²,

Alsanosy³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The study is the first of its kind to be conducted in Saudi Arabia (KSA), aiming to analyze the effectiveness of an intervention program in improving the knowledge of oral cancer among the youth. Materials and Methods: A total of 1,051 young Saudis (57% males and 43% females with a mean age of 20.4±1.98) were selected using multi-stage cluster sampling. Knowledge assessment was accomplished using a closed-ended questionnaire which was subjected to reliability tests. Prevalence of risk factors in relation to gender was analyzed using the chi-squared test. Effectiveness was calculated by comparing the pre-and post-intervention means, using the two-tailed paired t-test. Multiple logistic regression was employed in order to determine factors associated with awareness of risk habits, signs/symptoms and prevention of oral cancer. The significance level in this study was set at 0.05. Results: Females were seen to be more into the habit of sheesha smoking (3.3% rather than the use of other forms of risk factors. Prevalence of diverse risk factors such as cigarette smoking (20%), sheesha (15.3%), khat (27%) and shamma (9%) was seen among males. Gender and the use of modifiable risk factors among the study sample were significantly (p<0.001) associated with effectiveness of the intervention. The intervention program was highly effective (p<0.001) in improving the knowledge of oral cancer among the youth in Jazan, KSA. Multivariate analysis revealed that age and gender are the most significant factors affecting knowledge. Conclusions: The study gives a direction for further public health initiatives in this oral cancer prone region.

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“…The incidence of oral cancer is also increasing in developed countries. 2 The treatments of oral cancer include surgery, radiation or chemotherapy, depending on the stage and nature of the tumor. 3,4 Unfortunately, only marginal improvement is seen in many patients, and a complete cure is often not achieved.…”

mentioning

confidence: 99%

The novel DNA alkylating agent BO‐1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models

Sanjiv

Suman

et al. 2011

Intl Journal of Cancer

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Oral cancer is the fourth-most common cause of death in males and overall the sixth-most common cause of cancer death in Taiwan. Surgery, radiotherapy and chemotherapy combined with other therapies are the most common treatments for oral cavity cancer. Although cisplatin, 5-fluorouracil and docetaxel are commonly used clinically, there is no drug specific for oral cavity cancer. Here, we demonstrated that derivatives of 3a-aza-cyclopenta[a]indene, a class of newly synthesized alkylating agents, may be drugs more specific for oral cancer based on its potent in vitro cytotoxicity to oral cancer cells and on in vivo xenografts. Among them, BO-1090, bis(hydroxymethyl)-3a-aza-cyclopenta[a]indene derivative, targeted DNA for its cytotoxic effects as shown by inhibition of DNA synthesis (bromodeoxyuridine-based DNA synthesis assay), induction of DNA crosslinking (alkaline gel shift assay), and induction of DNA single-stranded breaks (Comet assay) and double-stranded breaks (c-H2AX focus formation). Following DNA damage, BO-1090 induced G1/S-phase arrest and apoptosis in oral cancer cell lines. The therapeutic potential of BO-1090 was tested in mice that received a xenograft of oral cavity cancer cell lines (SAS or Cal 27 cells). Intravenous injection of BO-1090 significantly suppressed tumor growth in comparison to control mice. BO-1090 also significantly reduced the tumor burden in orthotopic mouse models using SAS cells. There was no significant adverse effect of BO-1090 treatment with this dosage based on whole blood count, biochemical enzyme profiles in plasma and histopathology of various organs in mouse. Taken together, our current results demonstrate that B0-1090 may have potential as a treatment for oral cavity cancer.Oral cavity cancer involving the lesions occurred in the tongue, oropharynx and floor of the mouth is a prevalent type of cancer in developing countries such as India, Pakistan, Bangladesh and Taiwan. 1 In south-central Asia, it is the third-most common cancer, with an average incidence rate of 1 to 10 per 100,000 people. The incidence of oral cancer is also increasing in developed countries. 2 The treatments of oral cancer include surgery, radiation or chemotherapy, depending on the stage and nature of the tumor. 3,4 Unfortunately, only marginal improvement is seen in many patients, and a complete cure is often not achieved. Half of the patients diagnosed with oral cancer succumb to death within 5 years, and for those who survive, the quality of life remains poor. 1 Thus, development of a drug specific for oral cavity cancer is needed so that substantial improvement in treatment can be achieved.The cytotoxic and antitumor properties of alkylating agents are due to their ability to covalently bind to DNA. There are two types of DNA alkylating agents, monofunctional and bifunctional agents. Monofunctional alkylating agents mainly damage DNA by forming methylated adducts, whereas the damage induced by bifunctional alkylating agents includes monoadducts, intrastrand crosslinks and interstrand crossli...

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Oral cancer prevention and control – The approach of the World Health Organization

Cited by 520 publications

References 5 publications

Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan

Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan

Effectiveness of an Intervention Program on Knowledge of Oral Cancer among the Youth of Jazan, Saudi Arabia

The novel DNA alkylating agent BO‐1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models

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