Oral cancer: Deregulated molecular events and their use as biomarkers

Sinevici, Nicoleta; O’Sullivan, Jeff

doi:10.1016/j.oraloncology.2016.07.013

Cited by 95 publications

(93 citation statements)

References 48 publications

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“…Oral cancer is a subclass of head and neck cancer with substantial morbidity and mortality, and the worldwide incidence is estimated to be ∼275,000 cases annually . Epidemiological studies have indicated that smoking, betel nut chewing, and alcohol consumption are predominant risk factors triggering oral cancer .…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of Leucaena leucocephala on the metastasis and invasion of human oral cancer cells

Chung

Chen

Chang

et al. 2017

Environmental Toxicology

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Oral cancer is one of the most common cancers worldwide, and metastasis is recognized as a major factor causing its low survival rate. The inhibition of metastasis progress and the improvement of the survival rate for oral cancer are critical research objectives. Leucaena leucocephala from the mimosa branch Leucaena genus is native to Central and South America and has been used as a traditional remedy for treating various disorders. Previous studies have demonstrated antioxidant, anti-inflammatory as well as anticancer properties of L. leucocephala plant materials. However, the molecular mechanism underlying the anticancer effect induced by L. leucocephala remains unclear. In this study, we investigated the effect of L. leucocephala extract (LLE) on SCC-9 and SAS oral cancer cells and examined the potential inhibitory mechanisms involved. The results indicated that LLE attenuated the migration and invasion abilities of both SCC-9 and SAS cells by reducing the activity and protein expression of matrix metalloproteinases-2 (MMP-2). Regarding mitogen-activated protein kinase (MAPK) pathways, the phosphorylation of ERK1/2 and p38 exhibited a significant inhibitory effect in the presence of LLE. The application of ERK inhibitor and p38 inhibitor confirmed that both signalling transduction pathways were involved in the inhibition of cell metastasis. These data indicate that L. leucocephala could be a potent therapeutic agent for the prevention and treatment of oral cancer and a prominent plant source for anticancer research in the future.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effects of Leucaena leucocephala on the metastasis and invasion of human oral cancer cells

Chung

Chen

Chang

et al. 2017

Environmental Toxicology

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“…During carcinogenesis, several pathways may be altered that modify tumour proliferation and apoptosis and induce a transformed cell to a clonal expansion of tumour cells. Some aberrant genes or proteins of this tumour expansion could serve as biomarkers of tumour progression and prognosis …”

Section: Introductionmentioning

confidence: 99%

“…Aberrant expression of EGFR, p53, p16, cyclin D1 has been proposed as having a prognostic influence on oral cancer . For several decades, researchers have speculated that ~6 mutations in key genes were both necessary and sufficient to cause cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Califano's group working on head and neck cancer have described models that involve a sequence of genetic changes that are involved in the evolution of cancer . Most authors have studied these molecular changes as individual proteins, and their significance described as single markers has not been clear . We therefore hypothesised that evaluation of several biomarkers studied all together in a single cohort of oral cancers may provide a better characterisation of markers which have a predictive influence on patients with OSCC.…”

Section: Introductionmentioning

confidence: 99%

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An immunohistochemical score to predict the outcome for oral squamous cell carcinoma

Monteiro

Diniz‐Freitas

Warnakulasuriya

et al. 2018

J Oral Pathology Medicine

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“…OSCC, a highly genetically heterogeneous cancer, is the sixth important malignancy with an annual worldwide prevalence of 275,000 cases. OSCC is caused by the invasion of mucosal epithelial cells to lamina propria (Sinevici & O’sullivan, ).…”

Section: Introductionmentioning

confidence: 99%

The promise of stem cell markers in the diagnosis and therapy of epithelial dysplasia and oral squamous cell carcinoma

Mohajertehran

Sahebkar

Zare

et al. 2018

Journal Cellular Physiology

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Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer. Epithelial dysplasia is often initiated in the cells and cell nuclei adjacent to the epithelial cell membrane. Reduced cell-cell adhesions enable cancer cells to detach from the tumor and disseminate to other organs. The mutations in epithelial dysplasia markers such as E-cadherin and epithelial cell adhesion molecules (CD326) can lead to proliferation, growth and survival of the tumor cells and persistence of numerous malignancies that play a key role in epithelial dysplasia of OSCC. Accordingly, these genes can be considered prognostic markers or potential therapeutic targets for the tailored management of patients with OSCC. The gene expression profile of OSCC stem cells indicates a differential pattern that facilitates establishing a cell signature. Owing to the highly tumorigenic behavior of cancer stem cells and the role of these cells in tumor differentiation, treatment resistance, relapse, and metastasis, we reviewed the role of stem cell markers in epithelial dysplasia and OSCC.

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Oral cancer: Deregulated molecular events and their use as biomarkers

Cited by 95 publications

References 48 publications

Inhibitory effects of Leucaena leucocephala on the metastasis and invasion of human oral cancer cells

Inhibitory effects of Leucaena leucocephala on the metastasis and invasion of human oral cancer cells

An immunohistochemical score to predict the outcome for oral squamous cell carcinoma

The promise of stem cell markers in the diagnosis and therapy of epithelial dysplasia and oral squamous cell carcinoma

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