Oral calcium carbonate administration ameliorates the progression of renal failure in rats with hypertension

Nakamura, Makoto; Suzuki, Hiromichi; Ohno, Yoichi; Ohishi, Akira; Yamakawa, Hiroshi; Okada, Hirokazu; Saruta, Takao

doi:10.1016/0272-6386(95)90574-x

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Calcium carbonate improved progressive renal damage in deoxycorticosterone acetate (DOCA)-salt model in rats mainly by its phosphate binding action [37], but acid-base status was not determined, and carbonate may also have a mild alkalinizing effect. Hatton and McCarron [38] postulated that calcium has antihypertensive actions mediated by many different possible mechanisms.…”

Section: Calcium Effectsmentioning

confidence: 99%

Calcium citrate ameliorates the progression of chronic renal injury

Gadola

Noboa

Márquez

et al. 2004

Kidney International

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Section: Calcium Effectsmentioning

confidence: 99%

Calcium citrate ameliorates the progression of chronic renal injury

Gadola

Noboa

Márquez

et al. 2004

Kidney International

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“…Bei rechtzeitiger Therapie können die schädlichen Folgen für den Organismus vermindert werden [2][3][4][5][6] Während im Erwachsenenalter bereits recht detaillierte Kosten/Nutzen Analysen des "early referral" erhoben und gegen Risiken einer zu späten Zuweisung abgewogen wurden, gibt es in der Pädiatrie keine derartigen Daten [7][8][9][10][11]. Es ist allerdings anzunehmen, dass gerade in der Zeit der Entwicklung und Reifung der Nierenfunktion besonders vulnerable Verhältnisse bestehen, und somit eine frühzeitige spezialisierte Betreuung zusätzliche Vorteile aufweisen könnte [12,13].…”

Section: Introductionunclassified

Referral to the pediatric dialysis unit – The earlier the better?

Böhm

Arbeiter

Muller

et al. 2005

Wien Klin Wochenschr

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Whereas recent research has demonstrated clear evidence for beneficial effects of early referral to the nephrologist in chronic renal insufficiency in adults, no such data exist for the pediatric population. In this study, we therefore correlated patient age and residual renal function at first presentation to a specialized pediatric nephrologist with the extent of secondary uremic complications and the further course of renal function. From March 2003 until March 2004, 43 children (34 boys, aged 10.1 +/- 6.3 yrs) with congenital-urologic (n = 26), congenital-nephrologic (n = 13) or acquired (n = 4) renal diseases had been followed for 3.9 yrs (14 days to 17.5 yrs) at the Kinderdialyse Wien, with a residual renal function of 35 +/- 20.5 ml/min/1.73 m(2) at first presentation. With regards to uremic secondary complications, the majority of children exhibited involvement of at least two systems at first presentation. Thereafter, children with congenital diseases who were referred to the specialized pediatric nephrology unit within the first year of live demonstrated a significantly better course of residual renal function (1.8% vs -0.7%, p = 0.034) than children who were referred later. These data confirm recent registry reports on chronic renal insufficiency in children. Only about a third of the children of our population were presented to a specialized pediatric nephrology center within their first year of life (despite a congenital disease in 90% of them). Thus, therapeutic interventions might be currently offered at a delayed time point in the majority of children.

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“…In addition to ameliorating the progression of renal failure thus, these phosphate binders are reported to lower blood pressure. [22][23][24][25] Although the causeresult relationship between the amelioration of renal failure progression and antihypertensive response remains unclear, it might be possible that phosphate depletion reduced vascular reactivity to vasoactive hormones and lowered blood pressure. 26 Because phosphate is reabsorbed in the proximal tubules via transporters coupled with sodium, 27 an increase in serum phosphate stimulates sodium reabsorption.…”

Section: Discussionmentioning

confidence: 99%

Oral carbonaceous absorbent modifies renal function of renal ablation model without affecting plasma renin-angiotensin system or protein intake

Horike

Usami

Kamiya

et al. 2003

Clinical and Experimental Nephrology

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Proteinuria was significantly greater in the controls than in the AST-120 group (102 +/- 22 vs 51 +/- 7 mg/day at 22 weeks). Urea clearance was lower in the former (3.7 +/- 0.4 vs 3.9 +/- 0.4 ml/min). There were no differences in plasma renin activity (1.4 +/- 0.3 vs 1.9 +/- 0.4 mg/ml per h), or in angiotensin I (756 +/- 119 vs 1042 +/- 168 pg/ml) and II (35.1 +/- 7.4 vs 46.6 +/- 7.6 pg/ml) or angiotensin-converting enzyme activity (39.0 +/- 2.4 vs 37.9 +/- 2.2 IU/l) between the two groups. Protein intake, estimated from urinary urea appearance, was not different. Serum phosphate concentration (6.6 +/- 0.3 vs 5.9 +/- 0.3 mg/dl) was higher in the control than in AST-120, while the urinary phosphate excretion rate (31.5 +/- 0.8 vs 28.1 +/- 1.8 mg/day) tended to be lower in the latter. Conclusions. AST-120 retarded the progression of renal failure in the 4/5 renal ablation model without affecting the plasma renin-angiotensin system or protein intake, both of which were the most important risk factors for the progression of renal failure. We hypothesize that the renal protective effects of the oral absorbent AST-120 may be, at least in part, due to its lowering phosphate absorption from the diet as a phosphorus binder.

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Oral calcium carbonate administration ameliorates the progression of renal failure in rats with hypertension

Cited by 5 publications

References 25 publications

Calcium citrate ameliorates the progression of chronic renal injury

Calcium citrate ameliorates the progression of chronic renal injury

Referral to the pediatric dialysis unit – The earlier the better?

Oral carbonaceous absorbent modifies renal function of renal ablation model without affecting plasma renin-angiotensin system or protein intake

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