Oral calcidiol is a good form of vitamin D supplementation

Biondi, Piergianni; Pepe, Jessica; Biamonte, Federica; Occhiuto, Marco; Parisi, Martina; Demofonti, Chiara; Baffa, Valeria; Minisola, Salvatore; Cipriani, Cristiana

doi:10.11138/ccmbm/2017.14.1.207

Cited by 10 publications

(13 citation statements)

References 14 publications

(17 reference statements)

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“…Until a few years ago, the guidelines estimated that the daily intake of vitamin D required to maintain adequate levels in the blood was 200 IU (5 mcg) in adults 19‒50 years of age, 400 IU (10 mcg) in adults 51‒69, and at least 600 IU (15 mcg) in those >70. 31 , 34 These guidelines have now been revised and it is currently believed that the amount of vitamin D that should be taken daily is 2,000 IU (50 mcg) or, in certain cases (e.g., for pregnant women), up to 4,000 IU (100 mcg). 31 , 34 …”

Section: Discussionmentioning

confidence: 99%

“… 31 , 34 These guidelines have now been revised and it is currently believed that the amount of vitamin D that should be taken daily is 2,000 IU (50 mcg) or, in certain cases (e.g., for pregnant women), up to 4,000 IU (100 mcg). 31 , 34 …”

Section: Discussionmentioning

confidence: 99%

“… 31 This deficiency increases with age and encompasses the vast majority of the elderly population of northern Italy who are not taking any supplements. 31 , 34 …”

Section: Introductionmentioning

confidence: 99%

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Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients

Mangano¹,

Oskouei

Paz

et al. 2018

J Dent Res Dent Clin Dent Prospects

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Background. Since osseointegration depends on bone metabolism, low levels of vitamin D in the blood may negatively affect bone formation around dental implants. To date, only a few studies have investigated the possible connection between serum levels of vitamin D and early dental implant failure (EDIF), i.e. failure that occurs within 4 months after placement, before the connection of the prosthetic abutment. The aim of this study was to investigate whether there is a relationship between low serum levels of vitamin D and EDIF. Methods. Data used for this retrospective study were derived from the records of a private dental clinic. Inclusion criteria were patients who had been treated with dental implants, inserted with a submerged technique from January 2003 to December 2017. EDIF was the outcome of this study. Chi-squared test was used to investigate the effect of patient-related variables (age, gender, smoking habit, history of periodontal disease and serum levels of vitamin D) on EDIF. Results. Originally, 885 patients treated with 1,740 fixtures were enrolled in this study. Overall, 35 EDIFs (3.9%) were reported. No correlation was found between EDIF and the patients' gender (P=0.998), age (P=0.832), smoking habit (P=0.473) or history of periodontal disease (P=0.386). Three EDIFs (11.1%) were reported in 27 patients with serum levels of vitamin D <10 ng/mL, 20 EDIFs (4.4%) in 448 patients with levels between 10 and 30 ng/mL, and 12 EDIFs (2.9%) in 410 patients with levels >30 ng/mL. Although there was a clear trend toward an increased incidence of EDIF with lowering of serum vitamin D levels, no statistically significant difference (P=0.105) was found among these three groups. Conclusion. Within its limitations (retrospective design, low number of patients with severe blood levels of vitamin D enrolled), this study failed to demonstrate a significant relationship between low serum levels of vitamin D and increased risk of EDIF. However, since a dramatic increase in EDIFs with lowering of vitamin D levels in the blood has been reported, further clinical studies with appropriate design (prospective or randomized controlled studies on a larger sample of severely deficient patients) are needed to better investigate this topic

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients

Mangano¹,

Oskouei

Paz

et al. 2018

J Dent Res Dent Clin Dent Prospects

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“…Obese patients (BMI > 30 kg/m 2 ) might require 2–3 times more vitamin D to both treat and prevent vitamin D deficiency and insufficiency [ 141 ]. Due to its pharmacokinetic profile, calcifediol might represent an alternative option [ 103 , 142 , 143 , 144 ].…”

Section: Special Contextsmentioning

confidence: 99%

Italian Association of Clinical Endocrinologists (AME) and Italian Chapter of the American Association of Clinical Endocrinologists (AACE) Position Statement: Clinical Management of Vitamin D Deficiency in Adults

et al. 2018

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Vitamin D deficiency is very common and prescriptions of both assay and supplementation are increasing more and more. Health expenditure is exponentially increasing, thus it is timely and appropriate to establish rules. The Italian Association of Clinical Endocrinologists appointed a task force to review literature about vitamin D deficiency in adults. Four topics were identified as worthy for the practicing clinicians. For each topic recommendations based on scientific evidence and clinical practice were issued according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) System. (1) What cut-off defines vitamin D deficiency: even though 20 ng/mL (50 nmol/L) can be considered appropriate in the general population, we recommend to maintain levels above 30 ng/mL (75 nmol/L) in categories at risk. (2) Whom, when, and how to perform screening for vitamin D deficiency: categories at risk (patients with bone, liver, kidney diseases, obesity, malabsorption, during pregnancy and lactation, some elderly) but not healthy people should be screened by the 25-hydroxy-vitamin D assay. (3) Whom and how to treat vitamin D deficiency: beyond healthy lifestyle (mostly sun exposure), we recommend oral vitamin D (vitamin D2 or vitamin D3) supplementation in patients treated with bone active drugs and in those with demonstrated deficiency. Dosages, molecules and modalities of administration can be profitably individually tailored. (4) How to monitor the efficacy of treatment with vitamin D: no routine monitoring is suggested during vitamin D treatment due to its large therapeutic index. In particular conditions, 25-hydroxy-vitamin D can be assayed after at least a 6-month treatment. We are confident that this document will help practicing clinicians in their daily clinical practice.

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“…suggested that (i) single vitamin D 3 bolus doses ≥300 000 IU represent a better option than previously described dose regimens in order to obtain a sufficient vitamin D status for up to 3 months and (ii) that vitamin D 3 is superior to vitamin D 2 in achieving higher and more sustained serum vitamin D levels. More recently, it was shown that oral calcifediol (25‐OH‐D 3 )—especially at the daily dose of 40 μg—should be preferred to oral cholecalciferol (D 3 ) because: (i) it induces a more rapid increase in serum vitamin D levels and in a linear dose–response fashion; (ii) it is more potent and therefore requires lower dosages; (iii) it displays better intestinal absorption; (iv) it provides a more stable serum vitamin D status . These recent new evidences on dose regimes of vitamin D supplementation might explain why approximately one billion people worldwide were previously reported to suffer from vitamin D deficiency/insufficiency despite the vast availability of oral vitamin D supplements …”

Section: Vitamin D Supplementationmentioning

confidence: 99%

Overview on vitamin D and sunbed use

Pierret

Suppa

Gandini

et al. 2019

Acad Dermatol Venereol

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Vitamin D seems to be associated with a protective effect in a vast range of diseases, including cardiovascular, autoimmune and oncologic conditions. Since ultraviolet (UV) B light is the most important prerequisite for the cutaneous synthesis of vitamin D, sunbeds are able to increase serum vitamin D levels, although only transiently in most cases. In this scenario, the artificial tanning industry relentlessly tries to promote the use of sunbeds as a ‘safe’ therapeutic measure to achieve an adequate serum vitamin D status. The World Health Organization classified UV‐emitting tanning devices, as well as the whole UV spectrum, as group‐1 carcinogens, as they significantly increase the risk of melanoma and non‐melanoma skin cancer. In case of vitamin D deficiency or insufficiency, the current risk‐benefit ratio is therefore in favour of vitamin D supplementation instead of sunbed use. Artificial tanning devices should never be considered as an option to achieve an appropriate vitamin D status. Their supposedly beneficial effects, vastly publicised by the artificial tanning industry, are not worth the carcinogenic risk associated with sunbed use.

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Oral calcidiol is a good form of vitamin D supplementation

Cited by 10 publications

References 14 publications

Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients

Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients

Italian Association of Clinical Endocrinologists (AME) and Italian Chapter of the American Association of Clinical Endocrinologists (AACE) Position Statement: Clinical Management of Vitamin D Deficiency in Adults

Overview on vitamin D and sunbed use

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