Oral bioavailability of levamisole in goats

Sahagún, Ana M.; Terán, María Teresa Cuesta; García, José Alejos; Fernández, Nélida; Sierra, Matilde; Diez, M. José

doi:10.1046/j.1365-2885.2001.00369.x

Cited by 11 publications

(8 citation statements)

References 19 publications

(36 reference statements)

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“…injections of levamisole t 1/2α = 0.177 h (Villanueva et al ., ); sheep t 1/2α = 0.53 h (i.m.) and 0.66 h (oral) (Fernández et al ., ); and goats (oral) t 1/2α = 0.37 h (Sahagún et al ., ). However, the most important data linked to residue accumulation are the elimination half‐life.…”

Section: Plasma Concentration Of Levamisole In Speckled Surubim Pseudmentioning

confidence: 97%

“…For example, for sheep, the elimination half‐lives were 2.34 h (i.m.) and 5.44 h (oral) (Fernández et al ., ); for goats t 1/2β = 1.44 h (oral) (Sahagún et al ., ); for swine, 9.3 and 6.9 h after oral and i.m. administration, respectively (Galtier et al ., ); for chicken, 5.7 h (El‐Kholy et al ., ); and for human; between 4.26 and 6 h (Luyckx et al ., ; Koussi et al ., ; Reid et al ., ).…”

Section: Plasma Concentration Of Levamisole In Speckled Surubim Pseudmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetic of levamisole in speckled surubimPseudoplatystoma corruscans

Zanon

Cerozi

Silva

et al. 2012

Vet Pharm & Therapeutics

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Section: Plasma Concentration Of Levamisole In Speckled Surubim Pseudmentioning

confidence: 97%

Section: Plasma Concentration Of Levamisole In Speckled Surubim Pseudmentioning

confidence: 99%

Pharmacokinetic of levamisole in speckled surubimPseudoplatystoma corruscans

Zanon

Cerozi

Silva

et al. 2012

Vet Pharm & Therapeutics

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“…Several studies have been done on pharmacokinetic profile of levamisole after different routes of administration in mammals (Fernandez, García, Sierra, Diez, & Terán, 1997, 1998; García, Diez, Sierra, & Terán, 1992; Sahagún et al, 2001; Villanueva et al, 2003); however, very limited number of studies are available on aquatics despite its wide application in fish species (Zanon, Cerozi, Silva, & Cyrino, 2012). This may be due to small size of fish which causes difficulties in serial blood sampling.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of levamisole after intramuscular and oral administrations to Caspian salmon (Salmo trutta caspius)

Tabari

Youssefi

Hosseinifard

et al. 2020

Vet Pharm & Therapeutics

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The pharmacokinetic parameters of levamisole were determined in the Caspian salmon after intramuscular (IM), oral by gavage, and oral by feed administrations. Eighty‐one healthy fish in three different groups received levamisole at the dose of 25 mg/fish by each route. Blood samples were collected at time points of 0, 0.5, 1, 2, 4, 6, 12, 14, and 24 hr after administrations. Plasma levamisole concentrations were measured by a validated high‐performance liquid chromatography (HPLC) assay and were analyzed using a noncompartmental approach. The mean terminal half‐life was 4.56, 3.95, and 2.91 hr for IM, gavage and feed routes, respectively. The peak plasma concentration for IM, gavage, and feed routes of levamisole were 35.53, 4.63, and 8.36 µg/ml, respectively, at the time of 0.25 for IM, and 1 hr for gavage and feed. The relative bioavailability for gavage and feed routes was 54.80 and 69.30. The similar bioavailability for gavage and feed might be indicative of similar efficacy for these routes of administrations. Further studies are warranted to evaluate the absolute oral bioavailability and the effective dose in Caspian salmon.

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“…Palermo and Milillo (1979) found out that the highest levamisole concentrations in muscle, liver and kidney sheep tissues were between 2 nd and 3 rd day with gradually depletion until the 7 th day after dosing. In another study it was found that levamisole concentrations in goat's blood plasma are depleted very fast and they are determined at least 6h after dosing (Sahagun et al 2001). Also, ΕΜΕΑ reports that in cattle, sheep, pigs and poultry levamisole residues in liver were <100μg/kg on day 7 after medication and > 10μg/kg on day 14 and < 10μg/kg on day 21.…”

Section: Introductionmentioning

confidence: 96%

“…Due to its potent broad-spectrum activity is used for the control of gastrointestinal and pulmonary nematodes in cattle, sheep and pigs acting as a nicotine-like ganglionic stimulant producing both muscarinic and nicotinic effects at cholinergic receptors (Cherlet et al 2000, Sahagun et al 2001, Braund 2003. It is the levoenantiomer of tetramisole and its optical resolution of D,L-tetramisole into its dextro-and levo-isomers revealed the levo-form to have more anthelminthic activity.…”

Section: Introductionmentioning

confidence: 99%

Tissue distribution and depletion of levamisole in sheep tissues

Tyrpenou

Xylouri-Frangiadaki

Frangiadakis

2017

J Hellenic Vet Med Soc

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The subject-matter of this project was the residue distribution and depletion of levamisole in the sheep tissues after a single administration of levamisole hydrochloride and with final aim the appropriate withdrawal time determination, so that sheep tissues will be safe for human consumption. Levamisole hydrochloride was given per os with a single dose in the form of a tablet of the pharmaceutical product Tridicine™ 300 mg at the recommended therapeutic dose of 300 mg/40 kg body weight (b.w.), a quantitycorresponding to 7.5 mg levamisole per kg b.w. Five sampling points comprised of four sheep each one , were performed at 24 h, 96 h, 168 h, 240 h and 336 h after medication. Tissue samples of muscle, liver, kidney and fat were collected, packed and stored at 45°C until analysis. Levamisole was determined by high performance liquid chromatography (HPLC) and mean levamisole concentrations found in the target tissues were detectable in all samples from the 1st until the 14th day after medication, with higher concentrations in kidney and liver ranging from 838.88 μg/kg to 39.18 μg/kg and from 1988.77 μg/kg to 16.58 μg/kg between the 1st and the 14th day, respectively. Concentrations in muscle and fat, the 1st day after medication, were 233.96 μg/kg and 173.89 μg/kg, respectively and the 4th day they were dropped below the maximum residue limit (MRL), which means that sheep tissues are safe for the consumer. A withdrawal time of 13 days was determined for liver, the main organ used for this calculation.

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Oral bioavailability of levamisole in goats

Cited by 11 publications

References 19 publications

Pharmacokinetic of levamisole in speckled surubimPseudoplatystoma corruscans

Pharmacokinetic of levamisole in speckled surubimPseudoplatystoma corruscans

Pharmacokinetics of levamisole after intramuscular and oral administrations to Caspian salmon (Salmo trutta caspius)

Tissue distribution and depletion of levamisole in sheep tissues

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