Oral bacteria inhibit Helicobacter pylori growth

Ishihara, Kazuyuki; Miura, Tadashi; Kimizuka, Ryuta; Ebihara, Yoshinori; Mizuno, Yoshio; Okuda, K

doi:10.1111/j.1574-6968.1997.tb10452.x

Cited by 62 publications

(29 citation statements)

References 21 publications

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“…41 The tendency to co-aggregate with F. nucleatum was also confirmed in another experiment. 42 In addition, it has been determined that P. gingivalis may also be involved in such interaction and that this is a fimbriae-dependent process. 42 On this basis, it can be concluded that the presence of H. pylori is strongly associated with the physiological functioning of these two bacterial species (F. nucleatum and P. gingivalis) within the dental plaque, and vice versa.…”

Section: Interactions Of Oral H Pylori With Microbial Fl Oramentioning

confidence: 99%

“…It has been observed that such microorganisms have the ability to inhibit H. pylori growth in vitro. 42 Diffusible compounds secreted by Streptococcus mutans 46 and Streptococcus mitis 47 contribute to a dramatic decrease in H. pylori viability. However, microscopic observation has shown that this effect was caused by the conversion of H. pylori to nonculturable coccoid forms.…”

Section: Interactions Of Oral H Pylori With Microbial Fl Oramentioning

confidence: 99%

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Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Krzyżek

Gościniak

2018

Dent. Med. Probl.

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The role of the oral cavity as a reservoir for Helicobacter pylori is still a controversial issue. There is a great number of articles indicating the presence of this pathogen in the oral cavity, but discrepancies among techniques for H. pylori detection and the variations in the patients tested often make it difficult to formulate a final verdict. Outer membrane proteins (OMPs) are one of the most important factors determining colonization of H. pylori in the oral cavity. Among them, the key role is attributed to BabA, SabA and NapA, all of which promote adherence and retention within this area. The oral cavity is characterized by the co-existence of numerous microorganisms which may potentially affect the physiology and morphology of H. pylori. The presence of coccoid-stimulating factors and relatively low levels of AI-2 in the early-to mid-stages of supragingival plaque allow dental H. pylori to colonize this niche as nonculturable spherical forms. On the other hand, subgingival plaque characterized by high numbers of periopathogens, capable of synthesizing high concentrations of AI-2, may favor the presence of mixed populations of spiral and coccoid H. pylori forms. This review article provides an up-to-date knowledge about the ability of oral H. pylori to interact both with the host and the local microflora of the oral cavity.

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Section: Interactions Of Oral H Pylori With Microbial Fl Oramentioning

confidence: 99%

Section: Interactions Of Oral H Pylori With Microbial Fl Oramentioning

confidence: 99%

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Krzyżek

Gościniak

2018

Dent. Med. Probl.

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“…[10][11][12] The transient existence of H pylori in the oral cavity seems to be associated with H pylori colonization in the stomach, but it is not known whether this reflects exposure to H pylori via an oral route or the presence of gastroesophageal reflux and the origin of this bacterium from the gastric lesions. 10 Because the prevalence of H pylori is low and decreasing among Finnish children, 13 we studied children only from refugee families of African origin. Among African children living in Finland, H pylori infection is common, and 63% of the children with gastrointestinal symptoms are seropositive for H pylori.…”

Section: Commentmentioning

confidence: 99%

Helicobacter pylori in Children Who Are Prone to Upper Respiratory Tract Infections

Pitkäranta

Kolho²,

Rautelin³

2005

Arch Otolaryngol Head Neck Surg

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To examine the presence of Helicobacter pylori infection in children with recurrent upper respiratory infections, including acute otitis media.Design: A prospective clinical trial.Setting: Tertiary referral center.Patients: A total of 20 children who were prone to upper respiratory infections and acute otitis and who were admitted for elective adenoidectomy and/or tympanostomy were included in the study.Main Outcome Measures: Samples of adenoid tissue and middle ear fluid were cultured for H pylori.Serologic analysis and fecal antigen detection testing were also carried out to determine the presence of H pylori.Results: The results of serologic and antigen detection tests were positive for H pylori in 4 children (20%), but cultures of adenoid tissue and middle ear fluid samples were negative for H pylori in all children. Conclusion:An association between H pylori infection and recurrent upper respiratory infections and otitis media could not be established.

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“…In addition, the antibacterial effects of other SCFAs produced by P. gingivalis or C. butyricum on H. pylori still remain to be determined. Ishihara et al (1997) found that P. gingivalis and F. nucleatum strongly coaggregated with H. pylori. This finding suggested that these resident oral bacteria might be effectively trapping newly transiting bacteria such as H. pylori in periodontal pockets of the oral cavity.…”

Section: Discussionmentioning

confidence: 97%

Destructive effects of butyrate on the cell envelope of Helicobacter pylori

Yonezawa

Osaki

Hanawa

et al. 2012

Journal of Medical Microbiology

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Helicobacter pylori can be found in the oral cavity and is mostly detected by the use of PCR techniques. Growth of H. pylori is influenced by various factors in the mouth, such as the oral microflora, saliva and other antimicrobial substances, all of which make colonization of the oral cavity by H. pylori difficult. In the present study, we analysed the effect of the cell supernatant of a representative periodontal bacterium Porphyromonas gingivalis on H. pylori and found that the cell supernatant destroyed the H. pylori cell envelope. As P. gingivalis produces butyric acid, we focused our research on the effects of butyrate and found that it significantly inhibited the growth of H. pylori. H. pylori cytoplasmic proteins and DNA were detected in the extracellular environment after treatment with butyrate, suggesting that the integrity of the cell envelope was compromised and indicating that butyrate has a bactericidal effect on H. pylori. In addition, levels of extracellular H. pylori DNA increased following treatment with the cell supernatant of butyric acid-producing bacteria, indicating that the cell supernatant also has a bactericidal effect and that this may be due to its butyric acid content. In conclusion, butyric acid-producing bacteria may play a role in affecting H. pylori colonization of the oral cavity.

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Oral bacteria inhibit Helicobacter pylori growth

Cited by 62 publications

References 21 publications

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Helicobacter pylori in Children Who Are Prone to Upper Respiratory Tract Infections

Destructive effects of butyrate on the cell envelope of Helicobacter pylori

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