Oral aspergillosis in a patient with acquired immunodeficiency syndrome

Rubin, Mitchell M.; Jui, Vivian; Sadoff, Rory S.

doi:10.1016/0278-2391(90)90019-x

Cited by 28 publications

(11 citation statements)

References 10 publications

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“…Invasive aspergillosis is rare and mainly affects immune-compromised hosts, causing destruction of the antral wall, antral pain, swelling, with or without sequelae from orbital invasion or intracranial extension. Following an initial sino-nasal localisation, oral lesions may develop, especially to the palate or the alveolar process, which appear as yellow to black necrotic ulcers of the palate or the posterior tongue [14,23]. Delayed diagnosis or inappropriate treatment may result in massive tissue destruction and possible extension into the cranial base and/or vault and orbit, via the blood flow, and determine blindness, lethargy, seizure and eventually death [2].…”

Section: Discussionmentioning

confidence: 99%

“…Aspergillosis usually occurs in immune-suppressed or debilitated individuals [31], such as patients with neutropenia [17], leukaemia [10,16,18,30], acquired immunodeficiency syndrome [23,27], cancer [25], treated with corticosteroids or with otherwise imbalanced macrophagic functions [24]. In such instances, inhaled spores [22] invade blood vessels, causing thrombosis and infarction and can erode through the facial planes, cartilagine and bone [2].…”

Section: Introductionmentioning

confidence: 99%

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Combined mucormycosis and aspergillosis of the oro-sinonasal region in a patient affected by Castleman disease

et al. 2004

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One case of aspergillosis and mucormycosis occurring in a patient with stage-IV Castleman disease was investigated. The patient, who had undergone polychemotherapy and was in otherwise good general condition, without lymphadenopathies or imbalance of the immune system, presented with a palatal ulceration that progressively involved the palatal mucosa and bone, the paranasal sinuses and the orbit. Repeated cultural examinations were always negative. He had undergone multiple cytological smears of the inflammatory infiltration and biopsies of both the oral and nasal mucosa, which resulted in extensive necrotic debris and suppurative inflammation, and, on the very last biopsy, fungal hyphae, spores and conidia were also detected. These were large, branching, mostly non-septate hyphae, associated with conidiophores and conidia, the latter appearing dark brown to black in the histological preparations. Following the diagnosis of combined mucormycosis and aspergillosis, the patient underwent prolonged topic and systemic antibiotic treatment that resulted curative. Mucormycosis usually is a fatal complication of head and neck or systemic disorders, leading to severe immune suppression. Nevertheless, early diagnosis may be achieved using a combination of special stains and may lead to effective antibiotic treatment and cure of the patient, even if associated with other opportunistic infections, such as aspergillosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combined mucormycosis and aspergillosis of the oro-sinonasal region in a patient affected by Castleman disease

et al. 2004

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“…The disease can be disseminated but primary head and neck aspergillosis mostly presents as paranasal sinus (5%) aspergillosis [8,6]. There are few cases of primary oral invasive aspergillosis [9,10].…”

Section: Introductionmentioning

confidence: 99%

Hard palate perforation due to invasive aspergillosis in a patient with acute lymphoblastic leukemia

Karabulut

Kabakas

Berköz

et al. 2005

International Journal of Pediatric Otorhinolaryngology

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“…We found only 23 reported cases of intraoral aspergillosis in the English literature (Schubert et al , 1986; Rubin, Jui and Sadoff, 1990; Shannon et al , 1990; Napoli and Donegan, 1991; Sugata et al , 1994; Chambers et al , 1995; Khatri et al , 2000). These cases and the one reported here are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Aspergillus is found in soil and vegetation. Its spores become airborne and can be inhaled to the lower respiratory tract, the most likely route for the fungus to enter the body (Rubin et al, 1990). However, spores of A. flavus can also contaminate food served to patients, be swallowed and implant in ulcerated areas as demonstrated by Bouakline et al (2000).…”

Section: Discussionmentioning

confidence: 99%

Primary aspergillosis affecting the tongue of a leukemic patient

et al. 2003

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We describe a case of primary aspergillosis involving the tongue of a patient with acute myeloid leukemia. Intraoral aspergillosis is very rare and we found only 23 cases reported in the English literature. Clinically it was a 2-cm, ulcerated, grayish lesion on the dorsum of the tongue. Microscopically there was invasion of the epithelium, connective tissue and muscle of the tongue by fungal hyphae branching at 45 degrees angle. The large hyphae were easily seen by H & E stain, and were strongly positive for periodic acid-Schiff and Grocott methenamine. The patient was successfully treated with intravenous amphotericin B. Based on clinical, microscopic and culture data, the diagnosis of primary aspergillosis of the tongue was established. Invasive oral aspergillosis is a potentially lethal disease and it should be considered in immunosuppressed patients.

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Oral aspergillosis in a patient with acquired immunodeficiency syndrome

Cited by 28 publications

References 10 publications

Combined mucormycosis and aspergillosis of the oro-sinonasal region in a patient affected by Castleman disease

Combined mucormycosis and aspergillosis of the oro-sinonasal region in a patient affected by Castleman disease

Hard palate perforation due to invasive aspergillosis in a patient with acute lymphoblastic leukemia

Primary aspergillosis affecting the tongue of a leukemic patient

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