Oral artemether for prevention of Schistosoma mansoni infection: randomised controlled trial

Utzinger, Jürg; N’Goran, Eliézer K.; N'Dri, A. Yao; Lengeler, Christian; Shuhua, Xiao; Tanner, Marcel

doi:10.1016/s0140-6736(00)02114-0

Cited by 199 publications

(123 citation statements)

References 20 publications

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“…This may be significant in Moyo and Adjumani Districts. Although the number of studies on S. mansoni is small, it has been shown that repeated doses of artemisinin derivatives, in combination with praziquantel, have a prophylactic effect in reducing the risk of S. mansoni, and some benefit for cure rates (Utzinger et al, 2000;Pérez del Villar et al, 2012). Artemisinin has been incorporated into guidelines for preventing S. japonicum in China (Liu et al, 2011).…”

Section: Drug Uptake In Moyo and Adjumani Districtsmentioning

confidence: 99%

Low Prevalence of Intestinal Schistosomiasis Among Fisherfolk Living Along the River Nile in North-Western Uganda: A Biosocial Investigation

Pearson

2016

J. Biosoc. Sci.

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SummaryMass drug administration has been less successful as a technique for controlling intestinal schistosomiasis (S. mansoni) than anticipated. In Uganda, the mass distribution of praziquantel has been provided to populations at risk of infection since the early 2000s, but prevalence mostly remains high. This is the case, for example, at locations in north-western and south-eastern Uganda. However, there is a remarkable exception. Among Madi fishing populations and their immediate neighbours, living close to the border with South Sudan, the rate of infection has dropped dramatically. A parasitological survey carried out at twelve fishing sites in 2013 identified only three cases of S. mansoni among 383 adults tested. This article asks: why is the prevalence of S. mansoni so low among fisherfolk in northern Uganda? Taking a biosocial approach, it suggests that the mass distribution of drugs, free of charge, has had an impact. However, the low prevalence of infection cannot be attributed to this alone. Other important factors may also have contributed to the decline in infection. These include changing fishing livelihoods, local attitudes to public health interventions, access to water and sanitation facilities, hygiene practices and the use of anti-malarial treatments. Above all, the article highlights the importance of investigating both social and biological dimensions of infection simultaneously, and of recognizing the local complexities of sustainably treating this debilitating parasitic disease.

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Section: Drug Uptake In Moyo and Adjumani Districtsmentioning

confidence: 99%

Low Prevalence of Intestinal Schistosomiasis Among Fisherfolk Living Along the River Nile in North-Western Uganda: A Biosocial Investigation

Pearson

2016

J. Biosoc. Sci.

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“…29 Given the interactive pathology between malaria and schistosomiasis and their co-endemicity in many sub-Saharan African communities, [30][31][32] mass screening and treatment of malaria using ACT could contribute to reducing both malaria transmission and the schistosomiaisis burden in sub-Saharan Africa. Therefore, future studies should investigate the complementary effects of ACTs and mass praziquantel administration for reducing both malaria and schistosomiais transmission in co-endemic communities.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Impact of Artemisinin-Based Combination Therapies on Malaria Transmission in Sub-Saharan Africa

Ndeffo-Mbah

Parikh

Galvani

2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Artemisinin-based combination therapies (ACTs) are currently considered the first-line treatments for uncomplicated Plasmodium falciparum malaria. Among these, artemether-lumefantrine (AL) has been the most widely prescribed ACT in sub-Saharan Africa. Recent clinical trials conducted in sub-Saharan Africa have shown that dihydroartemisinin-piperaquine (DP), a most recent ACT, may have a longer post-treatment prophylactic period and post-treatment infection period (duration of gametocyte carriage) than AL. Using epidemiological and clinical data on the efficacy of AL and DP, we developed and parameterized a mathematical transmission model that we used to compare the population-level impact of AL and DP for reducing P. falciparum malaria transmission in sub-Saharan Africa. Our results showed that DP is likely to more effectively reduce malaria incidence of clinical episodes than AL. However in low P. falciparum transmission areas, DP and AL are likely to be equally effective in reducing malaria prevalence. The predictions of our model were shown to be robust to the empirical uncertainty summarizing the epidemiological parameters. DP should be considered as a replacement for AL as first-line treatment of uncomplicated malaria in highly endemic P. falciparum communities. To optimize the effectiveness of ACTs, it is necessary to tailor treatment policies to the transmission intensity in different settings.

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“…Following treatment, artemether induces severe and extensive tegumental damage and significant reduction in glycogen contents through the inhibition of glycolsis, but the onset of this alteration is slow. It also hinders the development of egg laying adult worm pairs (Xiao et al, 2000).…”

Section: Mode Of Action Of Artemisininmentioning

confidence: 99%

“…The efficacy of oral artemether for prevention of S mansoni infection was investigated in Western Cote d'Ivore (Utzinger et al, 2000). The group that received artemether had a significantly lower incidence of S mansoni infection (31/128 versus 68/140, relative risk: 0.50 [95% CI 0.35-0.71], P=0.00006).…”

Section: Efficacy Of Artemisinin In Field Studiesmentioning

confidence: 99%

Control of Schistosomiasis

Useh¹

2012

Schistosomiasis

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Oral artemether for prevention of Schistosoma mansoni infection: randomised controlled trial

Cited by 199 publications

References 20 publications

Low Prevalence of Intestinal Schistosomiasis Among Fisherfolk Living Along the River Nile in North-Western Uganda: A Biosocial Investigation

Low Prevalence of Intestinal Schistosomiasis Among Fisherfolk Living Along the River Nile in North-Western Uganda: A Biosocial Investigation

Comparing the Impact of Artemisinin-Based Combination Therapies on Malaria Transmission in Sub-Saharan Africa

Control of Schistosomiasis

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