Oral and Salivary Gland Angiosarcoma: A Clinicopathologic Study of 29 Cases

Abstract

Angiosarcomas of the oral and salivary gland area are extremely rare, mostly presented as case reports. We wanted to study the clinicopathologic features of a series of oral and salivary gland angiosarcomas. Cases coded as "angiosarcoma" were retrieved from the Oral and Maxillofacial Pathology Department of the Armed Forces Institute of Pathology. Patient folders and pathology were reviewed and recorded; immunohistochemistry and follow-up were obtained. Inclusion required oral or salivary gland location, vasoformative growth, cytologic atypia, mitoses, and vascular markers. Skin, bone, and subcutaneous angiosarcomas were excluded. Primary and secondary (metastatic) oral angiosarcomas were included. The 22 primary angiosarcomas involved tongue (n ‫؍‬ 9), parotid (n ‫؍‬ 4), lip (n ‫؍‬ 4), submandibular gland (n ‫؍‬ 3), and 1 each of soft and hard palate. The 7 secondary angiosarcomas involved the gingiva (n ‫؍‬ 4) and parotid gland (n ‫؍‬ 3). Overall, patient ages ranged from 6 -90 years (mean, 55 years). There were 15 males and 14 females. Symptoms included a mass with recent enlargement and bleeding. Tumor sizes ranged from 0.8 -7.0 cm (mean, 2.6 cm). Histologically, all tumors were vasoformative; 86% had solid and 17% had distinctive papillary areas. Eight (28%) were classified as the epithelioid subtype. Immuno

Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

“…Endothelial differentiation can be confirmed by the vascular markers CD31 and CD34. These markers are expressed in most angiosarcomas of the oral cavity [11,13] but not in squamous cell carcinomas.…”

Angiosarcoma of the Oral Cavity

“…Angiosarcoma of the oral cavity may occur in various tissues, such as oral soft tissue, minor salivary glands, and bones [2][3][4][5]. The present case occurred in the cheek soft tissue in the oral cavity.…”

“…The present case occurred in the cheek soft tissue in the oral cavity. Fanburg-Smith et al [5] reported 22 cases of primary angiosarcoma of the oral and salivary glands. The sites of the 22 cases were tongue in 9, parotid gland in 4, lip in 4, submandibular gland in 3, and palate in 1 [5].…”

“…Fanburg-Smith et al [5] reported 22 cases of primary angiosarcoma of the oral and salivary glands. The sites of the 22 cases were tongue in 9, parotid gland in 4, lip in 4, submandibular gland in 3, and palate in 1 [5]. Male and female were equally affected [5].…”

“…Although angiosarcoma can occur in any location, the most common sites are soft tissue and skin [1]. Angiosarcoma of the oral cavity is extremely rare; there are a few case reports [2][3][4] and case series [5] in the literature. The author herein reports a small angiosarcoma of the left cheek mucosa next to the mandibular gingiva.…”