Angiosarcoma of the Oral Cavity

Terada, Tadashi

doi:10.1007/s12105-010-0211-5

Cited by 20 publications

(18 citation statements)

References 4 publications

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“…Considerable caution is needed when using cytokeratin expression as sole evidence of epithelial origin as the majority of epithelioid angiosarcomas are positive for pancytokeratin. P63 is strongly and diffusely expressed in oral squamous cell carcinomas, but it is not expressed in the limited number of epithelioid angiosarcomas tested to date [11,12]. Endothelial differentiation can be confirmed by the vascular markers CD31 and CD34.…”

Section: Discussionmentioning

confidence: 97%

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Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Olson

Püttgen

Westra

2011

Head and Neck Pathol

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Xeroderma pigmentosum (XP) is a rare autosomal recessive defect in DNA endonuclease activity that is associated with the development of cutaneous malignancies, at sun exposed sites, including basal cell carcinoma, squamous cell carcinoma, and melanoma. Squamous cell carcinomas are also known to target the anterior tongue. Patients sometimes develop angiosarcomas, and these invariably arise from sun-exposed skin. A biopsy was taken from a large mass arising in the anterior tongue of an 11-year-old girl with XP and a history of cutaneous basal cell carcinomas. The histopathologic findings demonstrated a high grade epithelioid neoplasm resembling a poorly differentiated squamous cell carcinoma, but the immunohistochemical profile (AE1/AE3 negative, p63 negative, CD31 positive, CD34 positive) established the diagnosis of angiosarcoma. Angiosarcoma is an XP-related tumor that usually arises in sun-exposed skin but can also arise in the oral cavity. For patients with XP who develop epithelioid neoplasms of the oral cavity, epithelioid angiosarcoma should be considered in the differential diagnosis.

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Section: Discussionmentioning

confidence: 97%

“…Endothelial differentiation can be confirmed by the vascular markers CD31 and CD34. These markers are expressed in most angiosarcomas of the oral cavity [11,13] but not in squamous cell carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Olson

Püttgen

Westra

2011

Head and Neck Pathol

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“…Due to variability in the sensitivity and specificity of markers used to assess vascular lineage, [9] cases described before CD 31 became commercially available were excluded. A total of 39 cases from 19 reports [4,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] were identified, including the new case reported herein. The clinical, microscopic, treatment and vital status data of the previously reported cases are summarized in Table 2.…”

Section: Review Of the Literaturementioning

confidence: 99%

Histologic and Immunopathologic Variability in Primary Intraoral Angiosarcoma: A Case Report and Review of the Literature

Battista

Darling

Scrivener³

et al. 2020

Head and Neck Pathol

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Primary intraoral angiosarcoma is an exceptionally rare malignancy of vascular origin which can be challenging to diagnose due to microscopic and immunohistochemical variability. A histopathologically challenging case of primary intraoral angiosarcoma, occurring in a pediatric patient is presented. A comprehensive review of the literature reveals that primary intraoral angiosarcomas occur with nearly equal frequency in males and females, affect the gingiva and the tongue most commonly and are treated primarily with surgery. As with angiosarcoma in other sites, primary intraoral angiosarcoma behaves aggressively with the majority of patients succumbing to their disease.

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“…Recently, we observed serendipitous staining for p63 in an angiosarcoma of the breast. Since p63 immunoreactivity has not been reported previously in angiosarcoma [17][18][19][20], we reasoned that further investigation of p63 expression in vascular tumors was warranted.…”

Section: Introductionmentioning

confidence: 99%

Occasional Staining for p63 in Malignant Vascular Tumors: A Potential Diagnostic Pitfall

Kallen

Rosado

González

et al. 2011

Pathol. Oncol. Res.

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Expression of p63, a putative marker for epithelial or myoepithelial differentiation, has been used to distinguish spindle cell carcinoma from sarcoma. The specificity of p63 for epithelial differentiation has not been thoroughly evaluated however, since p63 expression has been explored in only a handful of mesenchymal tumors. After observing unexpected immunohistochemical staining for p63 in an angiosarcoma of the breast, we evaluated a series of benign and malignant vascular tumors to determine the frequency of such a finding. Nuclear immunoreactivity to p63 was detected, at least focally, in 24% of malignant vascular tumors other than Kaposi sarcoma, which was uniformly negative. Benign vascular tumors were also negative for p63. Although p63 expression in tumors of vascular differentiation is unusual, it may be seen occasionally in some malignant vascular tumors. Thus, p63 is not entirely specific for epithelial differentiation. Since soft tissue angiosarcomas and hemangioendotheliomas sometimes express cytokeratins, the finding of nuclear p63 represents another potential pitfall in the differential diagnosis between poorly-differentiated carcinomas and vascular neoplasms.

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Angiosarcoma of the Oral Cavity

Cited by 20 publications

References 4 publications

Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Histologic and Immunopathologic Variability in Primary Intraoral Angiosarcoma: A Case Report and Review of the Literature

Occasional Staining for p63 in Malignant Vascular Tumors: A Potential Diagnostic Pitfall

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