Oral and lip cancer in solid organ transplant patients – A cohort study from a Swedish Transplant Centre

Abstract

This study shows that SOT patients have a higher risk of developing both oral and lip cancer, and in addition, that SOT patients with lip cancer have a worse prognosis.

The etiologic spectrum of head and neck squamous cell carcinoma in young patients

“…And it's reported that about 4-15% of all malignant tumors after transplantation are head and neck cancers and a large part of these head and neck cancers are squamous cell carcinomas of the lip or oropharynx [ 128 , 130 – 134 ]. Jenny et al reported that SOT patients have the risk increased 6 times for oral cancer, and for lip cancer 44 times in their cohort, and SOT patients with lip cancer have a worse prognosis compared with non-SOT patients [ 135 ]. In addition, Head and neck malignancies after SOT are inclined to affect younger recipients, and often have a more aggressive behavior, a worse prognosis [ 136 , 137 ].…”

Survival among solid organ transplant recipients diagnosed with cancer compared to nontransplanted cancer patients—A nationwide study

“…Some studies have assessed prognosis among OTRs diagnosed with a few specific cancer forms . Compared to nontransplanted cancer patients, worse survival has been observed for OTRs diagnosed with colon cancer and melanoma whereas results have been mixed for nonsmall cell lung cancer .…”

“…Some studies have assessed prognosis among OTRs diagnosed with a few specific cancer forms. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Compared to nontransplanted cancer patients, worse survival has been observed for OTRs diagnosed with colon cancer 12,14,15 and melanoma [17][18][19][20]24,26 whereas results have been mixed for nonsmall cell lung cancer. 14,22 In light of these findings, it has been suggested that cancers developing in the context of transplant-related immune suppression may have a different and more aggressive biology.…”

De Novo Head and Neck Cancer After Liver Transplant With Antibody-Based Immunosuppression Induction

“…Most studies addressing head and neck cancers in transplant patients report data collected in countries outside the United States (U.S.), where tumor registries are more easily cross-matched. [7][8][9][10][11]13,14 The reported incidence of all head and neck cancers at most centers is 6-7%, while non-cutaneous head and neck cancers are 1%. U.S. reports show lower rates, but the identification of tumors is likely less complete.…”

“…Transplant patients are known to have an increased risk for many types of tumors, especially dermatologic cancers frequently found in the head and neck region. [7][8][9][10][11][12][13][14][15] One group of patients at particular risk for post-transplant cancer are liver transplant patients because of the high incidence of alcohol abuse and tobacco use among this population. 16 Chronic exposure to these noxious substances has led to several published reports.…”