Oral and Genital Human Herpesvirus 8 and Human Papillomavirus in heterosexual partners

Brasil, Catarina da Mota Vasconcelos; Ribeiro, Camila Maria Beder; Leão, Jair Carneiro

doi:10.1111/j.1600-0714.2012.01184.x

Cited by 4 publications

(7 citation statements)

References 38 publications

(56 reference statements)

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“…In comparison, the latest research showed that 18/31 (58 percent) of female genital brush studies have identified HPV DNA, whereas none of those female brushstrokes is positively KSHV DNA [14]. Another study found that there was no detectable KSHV DNA in the cervical secretion of 112 females, although 2.7% and 24% respectively of serum samples from the same group were found to contain latent and lytic KSHV antibodies [15].It's now almost unclear whether HPV oncogenic gene expression in cervical cancer cells is regulated by KSHV infection or by KSHV-encoded proteins.…”

Section: Discussionmentioning

confidence: 93%

“…Another study found that there was no detectable KSHV DNA in the cervical secretion of 112 females, although 2.7% and 24% respectively of serum samples from the same group were found to contain latent and lytic KSHV antibodies [15].It's now almost unclear whether HPV oncogenic gene expression in cervical cancer cells is regulated by KSHV infection or by KSHV-encoded proteins. [12][13][14][15][16].The major viral oncoproteins closely related to cervical human carcinogenesis are high-risk HPV, as encoded E6 and E7 proteins, for example, under the subtypes 16 and 18 [1,2]. Proteins E6 and E7 can bind to the family proteins P53 and Rb resulting in the control and conversion of the cell cycle [3], respectively.E6 and E7 proteins have been recently shown to be interacting, regulating or contributing to the oncogenesis, and many more cellular elements, including proteins that control cell epigenetic traces and splicing modifications [1,3].…”

Section: Discussionmentioning

confidence: 99%

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Histopathological performance of an HPV18 \ KSHV co-infection with Kisspeptin expression in cervical precancer and cancer tissues

Muhsin¹,

Hadi²,

Abbas³

2019

AHRO

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Background: Cervical cancer (CC) is one of the most 12 th recurrent neoplasia among Iraqi women turning it into significant health issue, it had been currently supposed that the co-infection of High-risk human papillomavirus (HPV) and Kaposi sarcoma-associated herpesvirus (KSHV) which both share some transmission routes from one side, and the disruption of Kisspeptin expression in cervical tissues from the other side, which are collectivelyact as a causative agents and co-factors of cervical cancer progression.Aim: to compare the infection and \ or co-infection of HPV18 \ KSHV and the dysregulation of Kisspeptin expression between cervical dysplasia (pre-cancerous tissues) and cervical cancer (cancerous tissues) progression.Results: Overall, results showed a significant association between infection and \ or co-infection of HPV18 \ KSHV with both types of test tissues (pre-cancerous and cancerous), although the detection rate of KSHV DNA was very low in comparing with HPV18 DNA in both cervical tissue samples. Furthermore, a significant interaction of Kisspeptin low expression in cancerous samples compared to pre-cancerous tissues with viruses existence seem to involve significantly in Kisspeptin expression of CC.Conclusions: Data suggest KSHV co-infection may act as co-factor in the development of HPV related cervical carcinogenesis. Besides, the defect of low Kisspeptin expression serves as a great candidate for cervical carcinoma progression or maybe as a therapeutic target for CC.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Histopathological performance of an HPV18 \ KSHV co-infection with Kisspeptin expression in cervical precancer and cancer tissues

Muhsin¹,

Hadi²,

Abbas³

2019

AHRO

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“…HHV-8 infection was found in 16% and 8% of Spanish sex workers and general population, respectively and the odds ratio was found to be 2.2 [ 24 ]. HHV-8 DNA was also found in 3.2% and 0% of male and female genital brushing in Brazil, respectively [ 25 ]. However, HHV-8 DNA was not detected in any normal cervical secretions of Swedish women samples [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of human herpesvirus 8 in normal, premalignant, and malignant cervical samples of Iranian women

Chavoshpour-Mamaghani

Shoja

Mollaei-Kandelous

et al. 2021

Virol J

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Background Regard to this fact that the main transmission route of HPV and HHV-8 is via sexual activity, it is reasonable to speculate that coinfection of HPV and HHV-8 may have been played an important role in the development of cervical cancer. The aim of this study was to estimate the prevalence of HHV-8 and the frequency of HPV and HHV-8 coinfection in cervical samples of patients with cervical cancer and healthy individuals. Methods In total, 364 samples from 61 patients with cervical cancer, 124 women with premalignant lesions, and 179 healthy individuals were investigated by nested-PCR. Results The frequency of HHV-8 was found to be 22.9%, 17.7%, and 14.5% in cervical cancer, premalignant lesions, and normal specimens, respectively (P = 0.308). The overall prevalence of coinfection between HHV-8 and HPV was shown to be 16.2%. The HPV prevalence was higher in HHV-8 positive samples than HHV-8 negative specimens in all three studied groups and this difference was reached a statistically significant level (P = 0.002). However, no significant differences were found between HHV-8 positivity and HPV genotypes (P = 0.08). Conclusions Our results showed the higher rate of HHV-8 genome detection in cervical cancer group than control group. However, future studies with larger sample sizes and evaluation of expression of HHV-8 proteins are warranted.

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“…6 Another study reported the presence of HPV in 54% of women with clinically healthy oral mucosa but whose sexual partners presented HPV-associated genital lesions. 14…”

Section: Discussionmentioning

confidence: 99%

“…6,20 Several studies have linked multiple partners for oral sex and kissing with increased risk for acquisition of HPV. 3,7,14 Inconsistent use of preservatives can be a prevalent risk factor among sexually active young adults in Brazil. Barbosa and Koyama 21 described the Brazilian North and Northeast regions with the highest reports of men with more than one sexual partner/year.…”

Section: Non-usersmentioning

confidence: 99%

Elevated prevalence of high-risk HPV in healthy oral mucosa of users and nonusers of drugs in Northeastern Brazil

et al. 2019

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Variable rates of HPV infection have been reported in healthy oral mucosa worldwide. The main objective of this study was to detect and genotype HPV infection in users and nonusers of drugs with clinically healthy mucosa from the Northeast Brazil. Samples from 105 patients were amplified using the primers MY09/MY11 and GP5+/GP6+, and genotyping was performed by multiplex-PCR for HPV-6/11, 16 and 18. A total of 81.9% samples were positive. Among drug users, 84.5% presented the virus and 20.4% showed multiple infections. Among non-drug users, 78.7% were positive and 13.5% had multiple infections. Limited information is available on oral HPV in Brazilian population, especially for drug users, and our results showed higher HPV infection rates in both users and nonusers of drugs. More studies and researches focused on drug users including factors like sexual behavior, nutrition and cultural habits are necessary to enhance the comprehension of this relationship, and develop preventive strategies.

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Oral and Genital Human Herpesvirus 8 and Human Papillomavirus in heterosexual partners

Abstract: Based upon the results of this study, co-infection between HPV and HHV-8 in malignant and pre-malignant penile lesions is an unlikely finding.

Cited by 4 publications

References 38 publications

Histopathological performance of an HPV18 \ KSHV co-infection with Kisspeptin expression in cervical precancer and cancer tissues

Histopathological performance of an HPV18 \ KSHV co-infection with Kisspeptin expression in cervical precancer and cancer tissues

The prevalence of human herpesvirus 8 in normal, premalignant, and malignant cervical samples of Iranian women

Elevated prevalence of high-risk HPV in healthy oral mucosa of users and nonusers of drugs in Northeastern Brazil

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