Oral administration of transgenic barley expressing a <i>Culicoides</i> allergen induces specific antibody response

Jónsdóttir, Sigríður; Svansson, Vilhjálmur; Stefánsdóttir, Sara Björk; Mäntylä, Einar; Marti, Eliane; Torsteinsdóttir, Sigurbjörg

doi:10.1111/evj.12655

Cited by 10 publications

(13 citation statements)

References 27 publications

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“…The induced antibodies cross‐reacted with the corresponding allergen derived from another Culicoides species, C. obsoletus (Cul o 2), and were able to block binding of Cul n 2‐ as well as Cul o 2‐specific IgE from horses affected with Culicoides hypersensitivity. This approach might be a useful alternative for prevention and treatment of Culicoides hypersensitivity . Only one retrospective study was published looking at the success rate of AIT in 32 horses with environmental allergies .…”

Section: Equine Aitmentioning

confidence: 99%

“…Efficacy may be increased by combining any of the above with new methods of administration such as intralymphatic injection in companion animals. OIT with transgenic foods as explored in horses may also be of interest particularly in infants and young children as early allergen exposure associated with decreased development of clinical signs. However, larger controlled studies are needed to provide data about optimal allergen concentrations and type of immunomodulating adjuvants as well as their success rate.…”

Section: The Future Of Aitmentioning

confidence: 99%

“…This approach might be a useful alternative for prevention and treatment of Culicoides hypersensitivity. 68 Only one retrospective study was published looking at the success rate of AIT in 32 horses with environmental allergies. 69 An improvement of clinical signs with AIT was reported by 84% of the owners; more than half of the owners could cease concurrent medications.…”

Section: Equine Aitmentioning

confidence: 99%

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Allergen immunotherapy in people, dogs, cats and horses – differences, similarities and research needs

Mueller¹,

Jensen‐Jarolim

Roth‐Walter

et al. 2018

Allergy

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In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis. Initiating a regulatory response and a production of "blocking" IgG antibodies with AIT are similar mechanisms in human beings and dogs with allergic diseases. Although subcutaneous immunotherapy is used for atopic dermatitis in cats, data for its efficacy are sparse. There is some evidence for successful treatment of feline asthma with AIT. In horses, most studies evaluate the effect of AIT on insect hypersensitivity with conflicting results although promising pilot studies have demonstrated the prophylaxis of insect hypersensitivity with recombinant antigens of biting midges (Culicoides spp.). Optimizing AIT using allergoids, peptide immunotherapy, recombinant allergens and new adjuvants with the different administration types of allergen extracts will further improve compliance and efficacy of this proven treatment modality.

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Section: Equine Aitmentioning

confidence: 99%

Section: The Future Of Aitmentioning

confidence: 99%

Section: Equine Aitmentioning

confidence: 99%

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Allergen immunotherapy in people, dogs, cats and horses – differences, similarities and research needs

Mueller¹,

Jensen‐Jarolim

Roth‐Walter

et al. 2018

Allergy

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“…The availability of pure recombinant allergens should improve AIT in future. The potential of prophylactic immunization using intralymphatic immunization with recombinant allergens or with transgenic barley, expressing Culicoides allergens, is currently being explored . Using an active vaccination against IL‐5 resulted in significant improvement of symptoms in nearly 50% of the treated horses, thus being a promising treatment option …”

Section: Insect Bite Hypersensitivitymentioning

confidence: 99%

EAACI position paper: Comparing insect hypersensitivity induced by bite, sting, inhalation or ingestion in human beings and animals

Pali‐Schöll

Blank

Verhoeckx

et al. 2019

Allergy

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Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion animals to those in people. With few exceptions, the situation in human insect allergy is better documented than in animals. We focus on a review of recent literature and give overviews of the epidemiology and clinical signs.We discuss allergen sources and allergenic molecules to the extent described, and aspects of diagnosis, prophylaxis, management and therapy. K E Y W O R D S allergenic molecules in insects, comparative, insect bite hypersensitivity, insect food allergy, insect venom allergy Abbreviations: BAT, basophil activation test; CCD, cross-reactive carbohydrate determinant; CRD, component-resolved diagnosis; DBPCFC, double-blind placebo-controlled food challenge; FBH, flea bite hypersensitivity; HDM, house dust mite; IBH, insect bite hypersensitivity; IGR, insect growth regulator; LLR, large local reaction; MBH, mosquito bite hypersensitivity; RAST, radioallergosorbent test; VIT, venom immunotherapy.

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“…This study by S. Jonsdottir and colleagues in Iceland and Switzerland investigated a novel immunotherapy approach to Culicoides insect bite hypersensitivity (sweet itch) .…”

Section: Novel Immunotherapy For Sweet Itchmentioning

confidence: 99%

Highlights of recent clinically relevant papers

Wright¹

2017

Equine Veterinary Education

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Oral administration of transgenic barley expressing a Culicoides allergen induces specific antibody response

Cited by 10 publications

References 27 publications

Allergen immunotherapy in people, dogs, cats and horses – differences, similarities and research needs

Allergen immunotherapy in people, dogs, cats and horses – differences, similarities and research needs

EAACI position paper: Comparing insect hypersensitivity induced by bite, sting, inhalation or ingestion in human beings and animals

Highlights of recent clinically relevant papers

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