Oral administration of synthetic selenium nanoparticles induced robust Th1 cytokine pattern after HBs antigen vaccination in mouse model

Abstract

The present study proposed that the administration of SeNPs with a conventional HBs antigen vaccine induces a better immune response with a Th1 bias.

Inhibition of H1N1 influenza virus by selenium nanoparticles loaded with zanamivir through p38 and JNK signaling pathways

“…Mahdavi M. reported that oral administration of synthetic selenium nanoparticles (SeNPs) induced robust Th1 cytokine pattern aer hepatitis B virus vaccination in mouse model. 21 Another paper stated that SeNPs showed anti-type-1 dengue virus activity by attenuating cytopathic effect. 22 Due to their small diameter that making entrance to the cells easy, more and more nanophase materials are used as carriers of drugs or siRNA to construct novel nanostructured biomaterials in recent researches.…”

Local Effects on Airway Inflammation and Systemic Uptake of 5 nm PEGylated and Citrated Gold Nanoparticles in Asthmatic Mice

“…Two recent studies using the OVA asthma model with TiO 2 nanoparticles (primary particle size 22 nm) and graphene oxide (particle thickness 0.61 nm, other dimensions between 20 nm and 4 µm) showed similar results and a shift from a Th2‐dominated reaction to a Th1 pattern with fewer eosinophils but more neutrophils as a result of nanoparticle treatment . Also in other contexts, immunomodulation with Th1 shifts has been observed for nanoparticles of very different chemistry and size, such as sulfonate‐ and phosphonate‐functionalized polystyrene nanoparticles (245 and 227 nm), iron oxide nanoparticles (100 nm), aqueous fullerene C 60 nanoparticles (100 nm), and selenium nanoparticles (60 nm) . It is not clear whether the immunomodulation depends on specific nanoparticle properties, such as a negative surface charge as the only common feature of the above‐mentioned particles, or whether this is a more unspecific phenomenon.…”

Ефективність Пробіотичних Бактерій При Комбінованій Вакцинації Проти Гепатиту В В Експерименті

“…Aluminum hydroxide, which is currently widely used as an adjuvant in hepatitis B vaccines, effectively stimulates Th2-type immune response, but does not affect the Th1-mediated immune response [11]. At the same time, it is known that some probiotic bacteria can stimulate the production of interleukins-2, -12, as well as interferon-γ, promoting the development of Th1-type immune response [6].…”