Oral administration of rutoside can ameliorate inflammatory bowel disease in rats

Cruz, T.; Gálvez, Júlio; Ocete, M. A.; Crespo, M. E.; Medina, Fernanda; Zarzuelo, Antonio

doi:10.1016/s0024-3205(97)01164-8

Cited by 96 publications

(51 citation statements)

References 15 publications

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“…Meanwhile, previous studies have demonstrated the beneficial effects of two quercetin glycosides, rutin and quercitrin, in experimental models of rat colitis [11,12], which have also been demonstrated in the present study for quercitrin.…”

Section: Discussionsupporting

confidence: 85%

“…It is important to note that when the glycosylated forms of quercetin are assayed, there is usually a loss of activity in these effects in comparison with those obtained with the aglycone, due to the presence of the sugar moiety in the flavonoid structure [10]. On the contrary, both glycosides, quercitrin and rutoside, have shown to exert intestinal anti-inflammatory effects in experimental models of rat colitis [11,12], whereas no clear effects have been demonstrated for the aglycone form (unpublished results). The aim of this study was to clarify this controversy.…”

Section: Introductionmentioning

confidence: 99%

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In vivo quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway

et al. 2005

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Quercetin is a common antioxidant flavonoid found in vegetables, which is usually present in glycosylated forms, such as quercitrin (3-rhamnosylquercetin). Previous in vitro experiments have shown that quercetin exerts a bigger effect than quercitrin in the down-regulation of the inflammatory response. However, such results have not been reproduced in in vivo experimental models of intestinal inflammation, in which quercetin did not show beneficial effects while its glycosides, quercitrin or rutin, have demonstrated their effectiveness. In this study, we have reported that the in vivo effects of quercitrin in the experimental model of rat colitis induced by dextran sulfate sodium can be mediated by the release of quercetin generated after glycoside's cleavage by the intestinal microbiota. This is supported by the fact that quercetin, but not quercitrin, is able to down-regulate the inflammatory response of bone marrow-derived macrophages in vitro. Moreover, we have demonstrated that quercetin inhibits cytokine and inducible nitric oxide synthase expression through inhibition of the NF-jB pathway without modification of c-Jun N-terminal kinase activity (both in vitro and in vivo). As a conclusion, our report suggests that quercitrin releases quercetin in order to perform its anti-inflammatory effect which is mediated through the inhibition of the NF-jB pathway.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

In vivo quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway

et al. 2005

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“…As expected, colonic instillation of TNBS/ethanol triggered an intense inflammatory response that was restricted to the distal segment of the large bowel and characterized by extensive hemorrhage and bowel wall thickening of most of the distal colon [4][5][6][7]. The median damage score was 9(8-10) (p < 0.05 vs. control group).…”

Section: Inflammatory Responsementioning

confidence: 73%

“…We have previously found that quercitrin and rutin exert a beneficial effect in experimental colonic inflammation [4][5][6]. Oral administration of either flavonoid 2 h prior to trinitrobenzene sulfonic acid (TNBS) administration and daily thereafter reduces neutrophil infiltration, counteracts glutathione depletion and protects the mucosa from ulceration.…”

Section: Introductionmentioning

confidence: 99%

Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat

et al. 2002

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Quercitrin is a flavonoid with antiinflammatory activity in experimental colitis, associated with an antioxidative action and amelioration of water absorption in vivo. However, its mechanism of action is unclear. This study focuses on the effect of quercitrin (1 and 5 mg/kg) in the early stages (24 h) of trinitrobenzene sulfonic acid colitis. Treatment with the flavonoid prevented the increase in colonic malondialdehyde and inhibited nitric oxide synthase and alkaline phosphatase activity but had no significant effects on observable damage. No effect on neutrophil infiltration (myeloperoxidase) was observed. On the other hand, quercitrin exerted complex effects on colonic hydroelectrolytic transport, showing a slight potentiation of water absorption in vivo (5 mg/kg) as well as a normalization of carbachol stimulated electrogenic ionic transport in the proximal colon in vitro (5 mg/kg). It is concluded that the beneficial effects of quercitrin on trinitrobenzene sulfonic acid chronic colitis arise from an early downregulation of the inflammatory cascade that is associated with amelioration of the disturbances in hydroelectrolytic transport. D

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“…They are expected to be candidates for alternative medicine, especially if they have immunomodulatory effects on allergies or inflammation. Rutin has already been reported to ameliorate experimental colitis in rats [4] and mice [17] through attenuation of proinflammatory cytokine gene expression. Some flavonoids, such as quercetin, kaempferol, fisetin and rutin, have been identified to inhibit histamine release from human basophils and rat mast cells [7,22].…”

Section: Discussionmentioning

confidence: 98%

Orally Administered Rutin Inhibits the Gene Expression of Th2 Cytokines in the Gut and Lung in Aged Mice

Morimoto

Takagi

Higashi

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Rutin is one of the flavonoids derived from plants such as buckwheat and is well known as a powerful antioxidant. To determine whether dietary rutin could modulate mucosal immunity, we examined the gene expression of Th1/Th2 cytokines and the receptors in the gut and lung. Aged (18 months old, 18 M) C3H/HeN female mice were orally administered rutin for 10 days. The small intestine and lung were taken and analyzed by real-time PCR for gene expression. Interleukin (IL)-13 and IL-13R2 gene expression was significantly low (P<0.05 respectively) in the small intestine of aged rutin-fed mice. Meanwhile, there was no change in interferon  gene expression between control and rutin-fed mice. IL-13 gene expression was also downregulated in the lung. To examine the mechanism of the inhibitory effect of rutin on Th2 cytokines in aged mice, intestinal nitric oxide synthase (NOS) expression was evaluated. Rutin inhibited inducible NOS (NOS2) gene expression, but not neuronal NOS and endothelial NOS. Gene analysis of cells collected from the small intestine by laser capture dissection revealed that NOS2 expression was significantly inhibited in crypt regions. Thus, rutin might be effective against a Th2-dominant profile through NOS2 inhibition in aged mice.

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Oral administration of rutoside can ameliorate inflammatory bowel disease in rats

Cited by 96 publications

References 15 publications

In vivo quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway

In vivo quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway

Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat

Orally Administered Rutin Inhibits the Gene Expression of Th2 Cytokines in the Gut and Lung in Aged Mice

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