Oral Administration of Resveratrol-Loaded Solid Lipid Nanoparticle Improves Insulin Resistance Through Targeting Expression of SNARE Proteins in Adipose and Muscle Tissue in Rats with Type 2 Diabetes

Mohseni, Roohollah; Sadeghabadi, Zahra Arab; Ziamajidi, Nasrin; Abbasalipourkabir, Roghayeh; RezaeiFarimani, Azam

doi:10.1186/s11671-019-3042-7

Cited by 61 publications

(29 citation statements)

References 31 publications

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“…RSV molecules are highly stable when they are entrapped in SLN, thereby protecting RSV from degradation in biochemical reactions [32]. Additionally, the potential penetrating ability and cell uptake capacity of RSV-SLN affect the tissue accumulation of RSV that may be responsible for the effects of RSV-SLN in muscle tissue [15]. We mainly explored the improved protective effects and underlying mechanism of RSV-SLN on endurance performance and focused on the mitochondrial QC process.…”

Section: Discussionmentioning

confidence: 99%

“…SLNs, which can be metabolized by many organisms, can modulate drug release [11][12][13]. SLNs can efficiently protect encapsulated resveratrol drugs in the biological environment and improve their physiochemical properties [14][15][16]. Hence, this study evaluated the effect of RSV-loaded SLN (RSV-SLN) supplementation on exercise performance to explore its possible mechanisms.Maintaining mitochondrial function involves mitochondrial biogenesis, mitophagy, fusion, and fission.…”

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confidence: 99%

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Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control

Sun

Zhou

et al. 2019

Crystals

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Resveratrol (RSV) has various pharmacological effects; however, few studies have directly addressed the possible antifatigue effects of long-term endurance exercise. The clinical use of RSV is limited by its poor water solubility and extremely short plasma half-life. Solid lipid nanoparticles (SLNs) are considered as reasonable drug delivery systems to overcome some of these drawbacks and expand its applications. In this study, RSV-SLNs were successfully prepared through emulsification and low-temperature solidification. Results showed that RSV-SLN supplementation effectively enhanced endurance performance. RSV-SLN supplementation might enhance mitochondrial function by ameliorating mitochondrial quality control (QC), which was superior to RSV application. These results revealed an unexpected role of RSV-SLN compared with RSV in terms of linking nutrient deprivation to mitochondrial oxidant production through mitochondrial QC. A mitochondrion-mediated pathway was likely involved in RSV-SLN, thereby improving endurance performance. Overall, this study highlighted new possibilities for anti-physical-fatigue strategies.Crystals 2019, 9, 559 2 of 15 expand the applications of RSV to resolve some of these problems. Solid lipid nanoparticles (SLNs) are considered as an efficient drug delivery system because of their good physicochemical properties [9,10]. SLNs, which can be metabolized by many organisms, can modulate drug release [11][12][13]. SLNs can efficiently protect encapsulated resveratrol drugs in the biological environment and improve their physiochemical properties [14][15][16]. Hence, this study evaluated the effect of RSV-loaded SLN (RSV-SLN) supplementation on exercise performance to explore its possible mechanisms.Maintaining mitochondrial function involves mitochondrial biogenesis, mitophagy, fusion, and fission. The integration of this series of processes reflects mitochondrial quality control (QC). We hypothesized that chronic fatigue states induced by excessive endurance exercise might be linked to injured mitochondrial QC. This study was the first to explore the effects of RSV-loaded SLNs on gene regulation that involves mitochondrial QC following excessive endurance exercise in mice. These data improved the understanding of the role of RSV in a nanometer form as mitochondrial nutrition during successive sessions of prolonged endurance exercise. Materials and Methods Preparation of RSV-SLNsRSV-SLNs were produced by emulsification and low-temperature solidification. In brief, RSV (150 mg) (Aladdin Industrial Corporation, Shanghai, China), lecithin (100 mg), and stearic acid (200 mg) (Shanghai Chemical Reagent Company, Shanghai, China) were dissolved in 10 mL of chloroform in glass bottles as an organic phase through ultrasound. Myrj 52 (Sigma-Aldrich Co., St Louis, MO, USA) was dissolved in 30 mL of distilled water and heated to 75 ± 2 • C in a water bath as an aqueous phase. Under 1000 rpm mechanical stirring, the organic phase was injected into the hot water phase, and the solution was kept at 75 • ...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control

Sun

Zhou

et al. 2019

Crystals

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“…Another research report informs about improving insulin resistance by improving the expression of visfatin and RES feeding has improved the expression of glucose transporter GLUT2 and 4 in rats which are induced with diabetes [177]. Hence, RES was encapsulated in SLNs and tested the following parameters, such as fasting blood sugar (FBS), insulin, and oxidative stress in type II diabetes-induced rats [178].…”

Section: Treatment Of Insulin Resistance In Type 2 Diabetes With Resvmentioning

confidence: 99%

“…The SLN-RES nanoparticles that were prepared [178] had an average of 248 nm in size, zeta potential at 16.5 mV, and with a RES entrapment efficiency of 79.9%. These nanoparticles with RES had a sustained release of RES and hence had good bioavailability for RES.…”

Section: Treatment Of Insulin Resistance In Type 2 Diabetes With Resvmentioning

confidence: 99%

Resveratrol Nanoparticles: A Promising Therapeutic Advancement over Native Resveratrol

et al. 2020

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The importance of fruit-derived resveratrol (RES) in the treatment of various diseases has been discussed in various research publications. Those research findings have indicated the ability of the molecule as therapeutic in the context of in vitro and in vivo conditions. Mostly, the application of RES in in vivo conditions, encapsulation processes have been carried out using various nanoparticles that are made of biocompatible biomaterials, which are easily digested or metabolized, and RES is absorbed effectively. These biomaterials are non-toxic and are safe to be used as components in the biotherapeutics. They are made from naturally available by-products of food materials like zein or corn or components of the physiological system as with lipids. The versatility of the RES nanoparticles in their different materials, working range sizes, specificity in their targeting in various human diseases, and the mechanisms associated with them are discussed in this review.

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“…Administration of Res-SLNs significantly decreased oxidative stress and inhibited weight loss. Investigation of molecular signaling pathways demonstrated that Res-SLNs are capable of the up-regulation of SNARE resulting in attenuation of DM [23]. DM harmfully affects reproductive function.…”

Section: Introductionmentioning

confidence: 99%

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

et al. 2020

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Mitochondria are intracellular organelles with two distinct membranes, known as an outer mitochondrial membrane and inner cell membrane. Originally, mitochondria have been derived from bacteria. The main function of mitochondria is the production of ATP. However, this important organelle indirectly protects cells by consuming oxygen in the route of energy generation. It has been found that mitochondria are actively involved in the induction of the intrinsic pathways of apoptosis. So, there have been efforts to sustain mitochondrial homeostasis and inhibit its dysfunction. Notably, due to the potential role of mitochondria in the stimulation of apoptosis, this organelle is a promising target in cancer therapy. Resveratrol is a non-flavonoid polyphenol that exhibits significant pharmacological effects such as antioxidant, anti-diabetic, anti-inflammatory and anti-tumor. The anti-tumor activity of resveratrol may be a consequence of its effect on mitochondria. Multiple studies have investigated the relationship between resveratrol and mitochondria, and it has been demonstrated that resveratrol is able to significantly enhance the concentration of reactive oxygen species, leading to the mitochondrial dysfunction and consequently, apoptosis induction. A number of signaling pathways such as sirtuin and NF-κB may contribute to the mitochondrial-mediated apoptosis by resveratrol. Besides, resveratrol shifts cellular metabolism from glycolysis into mitochondrial respiration to induce cellular death in cancer cells. In the present review, we discuss the possible interactions between resveratrol and mitochondria, and its potential application in cancer therapy.

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Oral Administration of Resveratrol-Loaded Solid Lipid Nanoparticle Improves Insulin Resistance Through Targeting Expression of SNARE Proteins in Adipose and Muscle Tissue in Rats with Type 2 Diabetes

Cited by 61 publications

References 31 publications

Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control

Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control

Resveratrol Nanoparticles: A Promising Therapeutic Advancement over Native Resveratrol

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

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