Resveratrol Nanoparticles: A Promising Therapeutic Advancement over Native Resveratrol

Abstract

The importance of fruit-derived resveratrol (RES) in the treatment of various diseases has been discussed in various research publications. Those research findings have indicated the ability of the molecule as therapeutic in the context of in vitro and in vivo conditions. Mostly, the application of RES in in vivo conditions, encapsulation processes have been carried out using various nanoparticles that are made of biocompatible biomaterials, which are easily digested or metabolized, and RES is absorbed effectively. These biomaterials are non-toxic and are safe to be used as components in the biotherapeutics. They are made from naturally available by-products of food materials like zein or corn or components of the physiological system as with lipids. The versatility of the RES nanoparticles in their different materials, working range sizes, specificity in their targeting in various human diseases, and the mechanisms associated with them are discussed in this review.

Co-encapsulation of quercetin and resveratrol in zein/carboxymethyl cellulose nanoparticles: characterization, stability and in vitro digestion

“…10 Plant polyphenols are being explored for their potential as nutraceuticals in preventing and treating various kinds of chronic diseases. Resveratrol is a polyphenol mainly found in grapes, peanuts, blueberries, and some other foods, 11 which is reported to exhibit antioxidant activity, as well as protecting against cancer, cardiovascular, and neurodegenerative diseases. 12,13 Quercetin is a polyphenol found in many fruits and vegetables, including cranberries, tomatoes, and apples, 14 which has been reported to exhibit antioxidant, anti-inflammatory, anti-cancer, blood pressure lowering, and other biological activities.…”

Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression

“…As yet, some progress has been achieved in this context, as several nanocarriers have been developed to increase the bioavailability of resveratrol 49 . Most nanocarriers are biologically compatible and cause no toxicity for normal tissues 50 . However, toxicity of resveratrol‐loaded nanoparticles shall be investigated in pre‐clinical and clinical studies.…”

“…49 Most nanocarriers are biologically compatible and cause no toxicity for normal tissues. 50 However, toxicity of resveratrol-loaded nanoparticles shall be investigated in pre-clinical and clinical studies. Moreover, some nanoparticles may enhance absorption and bioavailability of drugs, thus high concentrations of drugs in certain organs may result in severe reactions.…”

Recent advances in herbal-based nanomedicine for anti-inflammatory purposes

“…Resveratrol 24 (RES) is a natural polyphenolic phytoalexin compound. It is produced by more than 70 species of plants in response to stressful situations.…”