Oral administration of rac-α-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial

Jacob, Stephan; Ruus, Peter; Hermann, Róbert; Tritschler, Hans; Maerker, Elke; Renn, W.; Augustin, H J; Dietze, G.; Rett, K.

doi:10.1016/s0891-5849(99)00089-1

Cited by 241 publications

(143 citation statements)

References 26 publications

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“…lated, which not only supports a role for LA as a mitigator of oxidative stress in this disease but also for its means to affect glucose handling (46,47). A number of reports now show that LA improves glucose disposal in patients with type 2 diabetes receiving LA (48,49).…”

Section: Clinical Applications Of Lamentioning

confidence: 71%

Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity

et al. 2008

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SummaryThe chemical reduction and oxidation (redox) properties of a-lipoic acid (LA) suggest that it may have potent antioxidant potential. A significant number of studies now show that LA and its reduced form, dihydrolipoic acid (DHLA), directly scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) species and protect cells against a host of insults where oxidative stress is part of the underlying etiology. However, owing to its limited and transient accumulation in tissues following oral intake, the efficacy of nonprotein-bound LA to function as a physiological antioxidant has been questioned. Herein, we review the evidence that the micronutrient functions of LA may be more as an effector of important cellular stress response pathways that ultimately influence endogenous cellular antioxidant levels and reduce proinflammatory mechanisms. This would promote a sustained improvement in cellular resistance to pathologies where oxidative stress is involved, which would not be forthcoming if LA solely acted as a transient ROS scavenger.

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Section: Clinical Applications Of Lamentioning

confidence: 71%

Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity

et al. 2008

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“…24 Another study reported a positive effect of oral administration of supplemental LA on insulin sensitivity and metabolic clearance rate in patients with type II diabetes. 25 In a randomized, double-blind, placebo-controlled clinical trial, Ansar et al 26 noted that ALA supplementation (300 mg, 8 weeks) could improve FBS and insulin resistance in patients with type II diabetes.Our result shows that a 12-week ALA supplementation has beneficial effects on anthropometric indices (body weight, BMI and waist circumference) and food intake in SCI patients. There is a large body of growing evidence showing that LA can have a substantial role in the regulation of food intake and anthropometric indices by suppressing appetite and elevating energy metabolism.…”

mentioning

confidence: 99%

The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial

et al. 2015

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Study design: A randomized, double-blind, placebo-controlled clinical trial. Objective: To assess the effect of alpha-lipoic acid (ALA) supplementation on IL-6, hs-CRP, FBS, anthropometric indices, food intake and blood pressure in male patients with chronic spinal cord injury (SCI). Setting: Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Methods: Fifty-eight men with chronic SCI participated in the study. Participants were divided in two groups: one group received 600 mg of supplemental ALA (n = 28) and the other group received placebo (n = 30) for 12 weeks. At the beginning and end of the study, biochemical parameters, anthropometric indices, blood pressure and dietary intakes were measured. Dietary intake was measured using N4 software, and statistical analyses were carried out using SPSS16. Results: No significant reduction was found in IL-6 (P = 0.97) and hs-CRP levels (P = 0.23). There was significant reduction in fasting blood sugar (P = 0.001), body weight (P = 0.001), BMI (P = 0.001), waist circumference (P = 0.001) and blood pressure (P = 0.001). Dietary intake was significantly reduced, including fat (P = 0.001), carbohydrate (P = 0.001), protein (P = 0.002) and energy intakes (P = 0.001). Conclusion: Lipoic acid supplementation had no significant effect on the measured inflammatory markers but it reduces fasting blood sugar, anthropometric parameters, food intake and blood pressure in men with chronic SCI. Spinal Cord (2015) 53, 621-624; doi:10.1038/sc.2015.35; published online 10 March 2015 INTRODUCTION Alpha-lipoic acid (ALA) or thiocitic acid is an eight-carbon, sulfurcontaining compound. It functions as a cofactor in the multienzyme complexes that catalyze the oxidative decarboxylation of α-keto acids. 1 There is general agreement about the antioxidant properties of ALA, which is thought to work by scavenging free radicals directly, chelating metallic ions, increasing intracellular glutathione and activating endogenous antioxidant systems. 2,3 ALA's antioxidant properties are thought to inhibit the deleterious mechanisms associated with inflammation; however, a number of studies suggest contradictory effects for ALA on inflammatory markers such as IL-6 and C-reactive protein (CRP). [4][5][6] Apart from the antioxidant properties of ALA, it is found to increase nitric oxide synthesis through which endothelial function is probably improved. 7 In addition, ALA reduces body weight and changes other anthropometric indices by suppressing appetite and increasing metabolism. [8][9][10][11][12] Spinal cord injury (SCI) is a devastating condition and entails considerable burden on the individual and society. 13,14 Persons with chronic SCI are at increased risk for obesity, cardiovascular disease, hypertension, diabetes, dyslipidemia and systemic inflammation [15][16][17][18][19] because of changes in their lifestyle, body composition and fat mass. 20 However, these complications may be preventable and treatable. 21 Studying the effect of ALA on cardiovascular risk factors and ...

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“…Recent studies have shown that LA improves insulin sensitivity in patients with type 2 diabetes. 33 Other studies have demonstrated that LA improves the effects of insulin on skeletal muscle glucose transport in animal models of insulin resistance. 34 Yasunari et al 35 have demonstrated that treatment with antioxidants improves impaired insulin-mediated glucose uptake in high glucose-fed rabbit.…”

Section: Midaoui and De Champlainmentioning

confidence: 98%

Prevention of Hypertension, Insulin Resistance, and Oxidative Stress by α-Lipoic Acid

2002

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Abstract-The aim of the present study was to investigate whether a dietary supplementation of ␣-lipoic acid could prevent blood pressure elevation, insulin resistance, and the increase in aorta superoxide anion production in a new experimental model of hypertension associated with insulin resistance. Sprague-Dawley rats were given 10% D-glucose in their drinking water combined either with a normal chow diet or with an ␣-lipoic acid-supplemented diet and were compared with control rats during 3 weeks. Oxidative stress was evaluated by measuring the aortic superoxide anion production using the lucigenin chemiluminescence method. Increases in blood pressure, insulin resistance, and aorta superoxide production observed in glucose-fed rats were prevented by the supplementation of the diet with lipoic acid. Positive correlations were found between aortic superoxide production and blood pressure, between insulin resistance and blood pressure, or between superoxide production and insulin resistance. Moreover, a decrease in the activity of plasma glutathione peroxidase observed in the glucose-fed rats was prevented by lipoic acid treatment. These findings demonstrate that high-glucose feeding rapidly induced hypertension and insulin resistance in association with the induction of a vascular oxidative stress. The antihypertensive action and the prevention of insulin resistance by lipoic acid appears to be associated to its antioxidative properties because it prevented the increase in oxidative stress, as reflected by the normalization of superoxide anion production in aorta and the prevention of the fall in the activity of glutathione peroxidase in the glucose-fed rats. (Hypertension. 2002;39:303-307.)

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Oral administration of rac-α-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial

Cited by 241 publications

References 26 publications

Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity

Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity

The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial

Prevention of Hypertension, Insulin Resistance, and Oxidative Stress by α-Lipoic Acid

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